Human Gene AKR7A2 (ENST00000235835.8_7) from GENCODE V47lift37
  Description: aldo-keto reductase family 7 member A2, transcript variant 1 (from RefSeq NM_003689.4)
Gencode Transcript: ENST00000235835.8_7
Gencode Gene: ENSG00000053371.14_14
Transcript (Including UTRs)
   Position: hg19 chr1:19,630,459-19,638,638 Size: 8,180 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr1:19,630,719-19,638,618 Size: 7,900 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:19,630,459-19,638,638)mRNA (may differ from genome)Protein (359 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: AKR7A2
Diseases sorted by gene-association score: pancreatic cystadenoma (15), gamma-amino butyric acid metabolism disorder (10), intermediate charcot-marie-tooth neuropathy (9), succinic semialdehyde dehydrogenase deficiency (9), contagious pustular dermatitis (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.18 RPKM in Adrenal Gland
Total median expression: 1290.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.8020-0.290 Picture PostScript Text
3' UTR -74.30260-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  LF206692 - JP 2014500723-A/14195: Polycomb-Associated Non-Coding RNAs.
BC004111 - Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase), mRNA (cDNA clone MGC:11105 IMAGE:3832140), complete cds.
BC011586 - Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase), mRNA (cDNA clone MGC:20401 IMAGE:4620484), complete cds.
BC013996 - Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase), mRNA (cDNA clone MGC:20271 IMAGE:3625337), complete cds.
AF026947 - Homo sapiens aflatoxin aldehyde reductase AFAR mRNA, complete cds.
AK225267 - Homo sapiens mRNA for aldo-keto reductase family 7, member A2 variant, clone: DMC05415.
BC007352 - Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase), mRNA (cDNA clone IMAGE:3615805), partial cds.
BC012171 - Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase), mRNA (cDNA clone MGC:20417 IMAGE:4642811), complete cds.
EU794591 - Homo sapiens epididymis secretory sperm binding protein Li 166mP (HEL-S-166mP) mRNA, complete cds.
JD401367 - Sequence 382391 from Patent EP1572962.
Y16675 - Homo sapiens mRNA for aflatoxin B1-aldehyde reductase.
BC010852 - Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase), mRNA (cDNA clone MGC:8910 IMAGE:3898226), complete cds.
JD221634 - Sequence 202658 from Patent EP1572962.
JD263625 - Sequence 244649 from Patent EP1572962.
JD095546 - Sequence 76570 from Patent EP1572962.
AK303131 - Homo sapiens cDNA FLJ51420 complete cds, highly similar to Aflatoxin B1 aldehyde reductase member 2 (EC 1.-.-.-).
DQ891003 - Synthetic construct clone IMAGE:100003633; FLH168434.01X; RZPDo839G1092D aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (AKR7A2) gene, encodes complete protein.
DQ894182 - Synthetic construct Homo sapiens clone IMAGE:100008642; FLH168430.01L; RZPDo839G1091D aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (AKR7A2) gene, encodes complete protein.
BT007347 - Homo sapiens aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) mRNA, complete cds.
KJ901887 - Synthetic construct Homo sapiens clone ccsbBroadEn_11281 AKR7A2 gene, encodes complete protein.
AK310609 - Homo sapiens cDNA, FLJ17651.
JD458345 - Sequence 439369 from Patent EP1572962.
MA442269 - JP 2018138019-A/14195: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2

-  Other Names for This Gene
  Alternate Gene Symbols: AKR7A2 , ENST00000235835.1, ENST00000235835.2, ENST00000235835.3, ENST00000235835.4, ENST00000235835.5, ENST00000235835.6, ENST00000235835.7, hCG_40469 , HEL-S-166mP , NM_003689, uc317ean.1, uc317ean.2, V9HWA2, V9HWA2_HUMAN
UCSC ID: ENST00000235835.8_7
RefSeq Accession: NM_003689.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.