ID:ALBU_HUMAN DESCRIPTION: RecName: Full=Serum albumin; Flags: Precursor; FUNCTION: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Plasma. PTM: Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys- 606. PTM: Glycated in diabetic patients. PTM: Phosphorylation sites are present in the extracellular medium. PTM: Acetylated on Lys-223 by acetylsalicylic acid. POLYMORPHISM: A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A. DISEASE: Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population. SIMILARITY: Belongs to the ALB/AFP/VDB family. SIMILARITY: Contains 3 albumin domains. CAUTION: A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed neurotensin- related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and blood flow. SEQUENCE CAUTION: Sequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAG35503.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Albumin Website; URL="http://www.albumin.org"; WEB RESOURCE: Name=Wikipedia; Note=Serum albumin entry; URL="http://en.wikipedia.org/wiki/Serum_albumin"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALB"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/alb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P02768
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK308044 - Homo sapiens cDNA, FLJ97992. AK314794 - Homo sapiens cDNA, FLJ95666, highly similar to Homo sapiens albumin (ALB), mRNA. BC034023 - Homo sapiens albumin, mRNA (cDNA clone MGC:22784 IMAGE:4734617), complete cds. BC036003 - Homo sapiens albumin, mRNA (cDNA clone MGC:32850 IMAGE:4724105), complete cds. BC041789 - Homo sapiens albumin, mRNA (cDNA clone MGC:32888 IMAGE:4766983), complete cds. AK292755 - Homo sapiens cDNA FLJ78413 complete cds, highly similar to Homo sapiens albumin, mRNA. AK298461 - Homo sapiens cDNA FLJ50830 complete cds, highly similar to Serum albumin precursor. AF119840 - Homo sapiens PRO0903 mRNA, complete cds. BC035969 - Homo sapiens albumin, mRNA (cDNA clone MGC:32581 IMAGE:4714468), complete cds. FW577652 - WO 2010131645-A/9: Synthesis method and amplification method of double stranded DNA corresponding to RNA. JB343258 - Sequence 9 from Patent EP2431465. JD073292 - Sequence 54316 from Patent EP1572962. BC034026 - Homo sapiens cDNA clone IMAGE:4734794, containing frame-shift errors. AK298437 - Homo sapiens cDNA FLJ54371 complete cds, highly similar to Serum albumin precursor. BC039235 - Homo sapiens albumin, mRNA (cDNA clone IMAGE:4768004), containing frame-shift errors. V00494 - Human messenger RNA for serum albumin (HSA). CR749331 - Homo sapiens mRNA; cDNA DKFZp779N1935 (from clone DKFZp779N1935). E00096 - DNA coding of human serum albumin. E00089 - cDNA encoding human serum albumin. V00495 - H.sapiens mRNA for serum albumin. A06977 - H.sapiens mRNA for albumin. E01107 - cDNA sequence of human serum albumin. AF542069 - Homo sapiens serum albumin (HSA) mRNA, complete cds. AY960291 - Homo sapiens serum albumin mRNA, complete cds. AY358313 - Homo sapiens DNA66677 ALB (UNQ696) mRNA, partial cds. DQ986150 - Homo sapiens serum albumin mRNA, complete cds. AY544124 - Homo sapiens growth-inhibiting protein 20 mRNA, complete cds. AY550967 - Homo sapiens cell growth inhibiting protein 42 mRNA, complete cds. DQ894588 - Synthetic construct Homo sapiens clone IMAGE:100009048; FLH176687.01L; RZPDo839G03121D albumin (ALB) gene, encodes complete protein. DQ891414 - Synthetic construct clone IMAGE:100004044; FLH176691.01X; RZPDo839G03122D albumin (ALB) gene, encodes complete protein. E02714 - cDNA sequence coding for human serum albumin prepro sequence. CU690238 - Synthetic construct Homo sapiens gateway clone IMAGE:100022252 5' read ALB mRNA. AF190168 - Homo sapiens serum albumin precursor, mRNA, complete cds. AY728024 - Homo sapiens serum albumin precursor, mRNA, complete cds. KJ905683 - Synthetic construct Homo sapiens clone ccsbBroadEn_15353 ALB gene, encodes complete protein. E00114 - DNA coding of pre human serum albumin. AF130077 - Homo sapiens clone FLB9714 PRO2619 mRNA, complete cds. E10762 - Variant cDNA encoding human serum albumin. E10763 - Variant cDNA encoding human serum albumin. E02049 - DNA encoding normal human serum albuminA. E02357 - cDNA sequence coding for human serum albumin A. E02580 - Human serum albumin gene. E02713 - cDNA sequence coding for human serum albumin. E02715 - cDNA sequence coding for human serum albumin A. E02717 - cDNA sequence coding for human serum albumin A. E10759 - Variant cDNA encoding human serum albumin. E10760 - Variant cDNA encoding human serum albumin. E10761 - Variant cDNA encoding human serum albumin. HQ537426 - Homo sapiens albumin mRNA, partial cds. E01037 - cDNA encoding human serum albumin. E01382 - cDNA encoding mature type of human albumin. JD023859 - Sequence 4883 from Patent EP1572962. JD030693 - Sequence 11717 from Patent EP1572962. AF119890 - Homo sapiens PRO2675 mRNA, complete cds. AF116645 - Homo sapiens PRO1708 mRNA, complete cds. AF118090 - Homo sapiens PRO2044 mRNA, complete cds. BC014308 - Homo sapiens, clone IMAGE:3934797, mRNA, partial cds. JD429532 - Sequence 410556 from Patent EP1572962. LP886326 - Sequence 218 from Patent WO2017201352. LP978083 - Sequence 218 from Patent WO2017120612. JD386394 - Sequence 367418 from Patent EP1572962. X51365 - Homo sapiens mRNA for albumin (clone pHA19). X51364 - Homo sapiens mRNA for albumin (clones pHA8, pHA25). X51363 - Homo sapiens mRNA for albumin (clones pHA1, pHA12). JD344604 - Sequence 325628 from Patent EP1572962. JD042051 - Sequence 23075 from Patent EP1572962. JD429799 - Sequence 410823 from Patent EP1572962. MB419105 - JP 2019519516-A/67: MRNA COMBINATION THERAPIES FOR THE TREATMENT OF CANCER. MB419970 - JP 2019519516-A/932: MRNA COMBINATION THERAPIES FOR THE TREATMENT OF CANCER.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P02768 (Reactome details) participates in the following event(s):
R-HSA-194153 Transport (efflux) of bile salts by ABCC3 (MRP3) R-HSA-264679 Serum albumin binds 2-lysophosphatidylcholine R-HSA-194079 SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol R-HSA-194083 SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol R-HSA-194121 Co-transport (influx) of bile salts and sodium ions by NTCP R-HSA-194130 Transport (influx) of bile salts and acids by OATP-A R-HSA-2168887 Ferriheme is transferred from Albumin to Hemopexin R-HSA-481007 Exocytosis of platelet alpha granule contents R-HSA-8952289 FAM20C phosphorylates FAM20C substrates R-HSA-159418 Recycling of bile acids and salts R-HSA-8964058 HDL remodeling R-HSA-879518 Transport of organic anions R-HSA-2168880 Scavenging of heme from plasma R-HSA-114608 Platelet degranulation R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-194068 Bile acid and bile salt metabolism R-HSA-8963899 Plasma lipoprotein remodeling R-HSA-425397 Transport of vitamins, nucleosides, and related molecules R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors R-HSA-76005 Response to elevated platelet cytosolic Ca2+ R-HSA-5619102 SLC transporter disorders R-HSA-8957322 Metabolism of steroids R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance R-HSA-425407 SLC-mediated transmembrane transport R-HSA-5653656 Vesicle-mediated transport R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-5619115 Disorders of transmembrane transporters R-HSA-556833 Metabolism of lipids R-HSA-382551 Transport of small molecules R-HSA-392499 Metabolism of proteins R-HSA-597592 Post-translational protein modification R-HSA-109582 Hemostasis R-HSA-1643685 Disease R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
