ID:APC16_HUMAN DESCRIPTION: RecName: Full=Anaphase-promoting complex subunit 16; Short=APC16; AltName: Full=Cyclosome subunit 16; FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: The APC/C is composed of at least 12 subunits. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. SIMILARITY: Belongs to the APC16 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96DE5
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK091047 - Homo sapiens cDNA FLJ33728 fis, clone BRAWH2017523. AX746749 - Sequence 274 from Patent EP1308459. LF208756 - JP 2014500723-A/16259: Polycomb-Associated Non-Coding RNAs. JD026566 - Sequence 7590 from Patent EP1572962. EU552924 - Homo sapiens metabolic syndrome-associated protein mRNA, complete cds. BC009530 - Homo sapiens chromosome 10 open reading frame 104, mRNA (cDNA clone MGC:10049 IMAGE:3890955), complete cds. JD266815 - Sequence 247839 from Patent EP1572962. JD033973 - Sequence 14997 from Patent EP1572962. JD442419 - Sequence 423443 from Patent EP1572962. JD203101 - Sequence 184125 from Patent EP1572962. CU679385 - Synthetic construct Homo sapiens gateway clone IMAGE:100016672 5' read C10orf104 mRNA. KJ895343 - Synthetic construct Homo sapiens clone ccsbBroadEn_04737 ANAPC16 gene, encodes complete protein. JD027578 - Sequence 8602 from Patent EP1572962. JD034335 - Sequence 15359 from Patent EP1572962. JD234867 - Sequence 215891 from Patent EP1572962. JD487021 - Sequence 468045 from Patent EP1572962. LF322519 - JP 2014500723-A/130022: Polycomb-Associated Non-Coding RNAs. JD297029 - Sequence 278053 from Patent EP1572962. JD040944 - Sequence 21968 from Patent EP1572962. LF322518 - JP 2014500723-A/130021: Polycomb-Associated Non-Coding RNAs. AK023981 - Homo sapiens cDNA FLJ13919 fis, clone Y79AA1000410. JD039555 - Sequence 20579 from Patent EP1572962. LF322517 - JP 2014500723-A/130020: Polycomb-Associated Non-Coding RNAs. JD435774 - Sequence 416798 from Patent EP1572962. JD513998 - Sequence 495022 from Patent EP1572962. JD513999 - Sequence 495023 from Patent EP1572962. JD069821 - Sequence 50845 from Patent EP1572962. JD415095 - Sequence 396119 from Patent EP1572962. JD415097 - Sequence 396121 from Patent EP1572962. JD272956 - Sequence 253980 from Patent EP1572962. JD356416 - Sequence 337440 from Patent EP1572962. JD341375 - Sequence 322399 from Patent EP1572962. LF322516 - JP 2014500723-A/130019: Polycomb-Associated Non-Coding RNAs. LF322515 - JP 2014500723-A/130018: Polycomb-Associated Non-Coding RNAs. JD204596 - Sequence 185620 from Patent EP1572962. JD063167 - Sequence 44191 from Patent EP1572962. JD542757 - Sequence 523781 from Patent EP1572962. JD212734 - Sequence 193758 from Patent EP1572962. JD198127 - Sequence 179151 from Patent EP1572962. JD413430 - Sequence 394454 from Patent EP1572962. JD246993 - Sequence 228017 from Patent EP1572962. JD246994 - Sequence 228018 from Patent EP1572962. MA558096 - JP 2018138019-A/130022: Polycomb-Associated Non-Coding RNAs. MA558095 - JP 2018138019-A/130021: Polycomb-Associated Non-Coding RNAs. MA558094 - JP 2018138019-A/130020: Polycomb-Associated Non-Coding RNAs. MA558093 - JP 2018138019-A/130019: Polycomb-Associated Non-Coding RNAs. MA558092 - JP 2018138019-A/130018: Polycomb-Associated Non-Coding RNAs. MA444333 - JP 2018138019-A/16259: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96DE5 (Reactome details) participates in the following event(s):
R-HSA-174119 Free APC/C phosphorylated by Plk1 R-HSA-174132 Free APC/C phosphorylated by Cyclin B:Cdc2 R-HSA-174139 Dissociation of phospho-Cdh1 from the APC/C complex R-HSA-141423 Binding of the MCC complex to the APC/C complex R-HSA-174070 Association of Cdh1 with the APC/C R-HSA-174224 Dissociation of Cdc20 from APC/C complex R-HSA-174057 Multiubiquitination of APC/C-associated Cdh1 R-HSA-188371 Association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788708 CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788725 Cdh1:APC/C complex binds EHMT1:EHMT2 R-HSA-174171 Association of Cyclin A with the APC/C R-HSA-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 R-HSA-179410 Association of Nek2A with MCC:APC/C R-HSA-174120 Association of Cyclin B:Cdc2 with Cdc20:APC/C complex R-HSA-174121 Association of Securin with Cdc20:APC/C complex R-HSA-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex R-HSA-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 R-HSA-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex R-HSA-179417 Multiubiquitination of Nek2A R-HSA-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex R-HSA-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex R-HSA-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex R-HSA-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex R-HSA-176412 Phosphorylation of the APC/C R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-2467813 Separation of Sister Chromatids R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-2559583 Cellular Senescence R-HSA-453276 Regulation of mitotic cell cycle R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-68882 Mitotic Anaphase R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-2262752 Cellular responses to stress R-HSA-69278 Cell Cycle (Mitotic) R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69620 Cell Cycle Checkpoints R-HSA-8953897 Cellular responses to external stimuli R-HSA-1640170 Cell Cycle R-HSA-68886 M Phase R-HSA-69239 Synthesis of DNA R-HSA-69242 S Phase R-HSA-69306 DNA Replication
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
