ID:APC5_HUMAN DESCRIPTION: RecName: Full=Anaphase-promoting complex subunit 5; Short=APC5; AltName: Full=Cyclosome subunit 5; FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: The APC/C is composed of at least 12 subunits. SIMILARITY: Belongs to the APC5 family. SIMILARITY: Contains 4 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UJX4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC045686 - Homo sapiens anaphase promoting complex subunit 5, mRNA (cDNA clone IMAGE:5301042), complete cds. AK054779 - Homo sapiens cDNA FLJ30217 fis, clone BRACE2001709, highly similar to Anaphase-promoting complex subunit 5 (APC5)(Cyclosome subunit 5). BC003095 - Homo sapiens cDNA clone IMAGE:3355753. BX537687 - Homo sapiens mRNA; cDNA DKFZp686D09196 (from clone DKFZp686D09196). BC034243 - Homo sapiens, Similar to anaphase promoting complex subunit 5, clone IMAGE:3463281, mRNA, partial cds. BC001081 - Homo sapiens anaphase promoting complex subunit 5, mRNA (cDNA clone MGC:2750 IMAGE:2823401), complete cds. BC001950 - Homo sapiens anaphase promoting complex subunit 5, mRNA (cDNA clone MGC:4377 IMAGE:2823401), complete cds. BC006301 - Homo sapiens anaphase promoting complex subunit 5, mRNA (cDNA clone MGC:13295 IMAGE:4100632), complete cds. AK025614 - Homo sapiens cDNA: FLJ21961 fis, clone HEP05554, highly similar to AF191339 Homo sapiens anaphase-promoting complex subunit 5 (APC5) mRNA. AB019409 - Homo sapiens mRNA, expressed in fibroblasts of periodontal ligament, complete cds, clone:PDL-108. AK301197 - Homo sapiens cDNA FLJ58697 complete cds, highly similar to Anaphase-promoting complex subunit 5 (APC5)(Cyclosome subunit 5). AK294139 - Homo sapiens cDNA FLJ55537 complete cds, highly similar to Anaphase-promoting complex subunit 5 (APC5)(Cyclosome subunit 5). AF191339 - Homo sapiens anaphase-promoting complex subunit 5 (APC5) mRNA, complete cds. AK315451 - Homo sapiens cDNA, FLJ96509. KJ893911 - Synthetic construct Homo sapiens clone ccsbBroadEn_03305 ANAPC5 gene, encodes complete protein. KJ906169 - Synthetic construct Homo sapiens clone ccsbBroadEn_15839 ANAPC5 gene, encodes complete protein. JD089979 - Sequence 71003 from Patent EP1572962. JD175132 - Sequence 156156 from Patent EP1572962. JD177883 - Sequence 158907 from Patent EP1572962. CU674542 - Synthetic construct Homo sapiens gateway clone IMAGE:100017801 5' read ANAPC5 mRNA. CU675341 - Synthetic construct Homo sapiens gateway clone IMAGE:100017483 5' read ANAPC5 mRNA. JD024100 - Sequence 5124 from Patent EP1572962. JD035377 - Sequence 16401 from Patent EP1572962. JD378705 - Sequence 359729 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UJX4 (Reactome details) participates in the following event(s):
R-HSA-174119 Free APC/C phosphorylated by Plk1 R-HSA-174132 Free APC/C phosphorylated by Cyclin B:Cdc2 R-HSA-174139 Dissociation of phospho-Cdh1 from the APC/C complex R-HSA-141423 Binding of the MCC complex to the APC/C complex R-HSA-174070 Association of Cdh1 with the APC/C R-HSA-174224 Dissociation of Cdc20 from APC/C complex R-HSA-174057 Multiubiquitination of APC/C-associated Cdh1 R-HSA-188371 Association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788708 CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788725 Cdh1:APC/C complex binds EHMT1:EHMT2 R-HSA-174171 Association of Cyclin A with the APC/C R-HSA-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 R-HSA-179410 Association of Nek2A with MCC:APC/C R-HSA-174120 Association of Cyclin B:Cdc2 with Cdc20:APC/C complex R-HSA-174121 Association of Securin with Cdc20:APC/C complex R-HSA-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 R-HSA-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex R-HSA-179417 Multiubiquitination of Nek2A R-HSA-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex R-HSA-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex R-HSA-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex R-HSA-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-176412 Phosphorylation of the APC/C R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-2467813 Separation of Sister Chromatids R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-2559583 Cellular Senescence R-HSA-453276 Regulation of mitotic cell cycle R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-68882 Mitotic Anaphase R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-2262752 Cellular responses to stress R-HSA-69278 Cell Cycle (Mitotic) R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69620 Cell Cycle Checkpoints R-HSA-1280218 Adaptive Immune System R-HSA-8953897 Cellular responses to external stimuli R-HSA-1640170 Cell Cycle R-HSA-68886 M Phase R-HSA-69239 Synthesis of DNA R-HSA-168256 Immune System R-HSA-69242 S Phase R-HSA-69306 DNA Replication
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
