ID:ANGP2_HUMAN DESCRIPTION: RecName: Full=Angiopoietin-2; Short=ANG-2; Flags: Precursor; FUNCTION: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. SUBUNIT: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1. INTERACTION: Q02763:TEK; NbExp=4; IntAct=EBI-2912111, EBI-2257090; SUBCELLULAR LOCATION: Secreted. DOMAIN: The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor. SIMILARITY: Contains 1 fibrinogen C-terminal domain. WEB RESOURCE: Name=Wikipedia; Note=Angiopoietin entry; URL="http://en.wikipedia.org/wiki/Angiopoietin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15123
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
