Human Gene ANKRD26 (ENST00000376087.5_9) from GENCODE V47lift37
  Description: ankyrin repeat domain containing 26, transcript variant 1 (from RefSeq NM_014915.3)
Gencode Transcript: ENST00000376087.5_9
Gencode Gene: ENSG00000107890.17_15
Transcript (Including UTRs)
   Position: hg19 chr10:27,293,045-27,389,423 Size: 96,379 Total Exon Count: 34 Strand: -
Coding Region
   Position: hg19 chr10:27,294,519-27,389,255 Size: 94,737 Coding Exon Count: 34 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:27,293,045-27,389,423)mRNA (may differ from genome)Protein (1710 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ANR26_HUMAN
DESCRIPTION: RecName: Full=Ankyrin repeat domain-containing protein 26;
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 5 ANK repeats.
SEQUENCE CAUTION: Sequence=BAA83026.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ANKRD26
Diseases sorted by gene-association score: thrombocytopenia 2* (1028), platelet disorder, familial, with associated myeloid malignancy* (202), myh-9 related disease (12), thrombocytopenia (12), thrombocytopenia-absent radius syndrome (8)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.53 RPKM in Pituitary
Total median expression: 87.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.60168-0.450 Picture PostScript Text
3' UTR -330.501474-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR021885 - DUF3496

Pfam Domains:
PF00023 - Ankyrin repeat
PF12001 - Domain of unknown function (DUF3496)
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)
PF14915 - CCDC144C protein coiled-coil region

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
48403 - Ankyrin repeat
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on Q9UPS8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0045599 negative regulation of fat cell differentiation

Cellular Component:
GO:0005813 centrosome


-  Descriptions from all associated GenBank mRNAs
  KJ902241 - Synthetic construct Homo sapiens clone ccsbBroadEn_11635 ANKRD26 gene, encodes complete protein.
BC110646 - Homo sapiens ankyrin repeat domain 26, mRNA (cDNA clone IMAGE:4385560), partial cds.
AL137351 - Homo sapiens mRNA; cDNA DKFZp434E0825 (from clone DKFZp434E0825).
LF384178 - JP 2014500723-A/191681: Polycomb-Associated Non-Coding RNAs.
LF365352 - JP 2014500723-A/172855: Polycomb-Associated Non-Coding RNAs.
AL162063 - Homo sapiens mRNA; cDNA DKFZp762D185 (from clone DKFZp762D185).
AK128577 - Homo sapiens cDNA FLJ46736 fis, clone TRACH3020769, weakly similar to Myosin heavy chain, nonmuscle type B.
AB028997 - Homo sapiens KIAA1074 mRNA for KIAA1074 protein.
JD298300 - Sequence 279324 from Patent EP1572962.
BC130453 - Homo sapiens ankyrin repeat domain 26, mRNA (cDNA clone MGC:163325 IMAGE:40146484), complete cds.
AB384103 - Synthetic construct DNA, clone: pF1KSDA1074, Homo sapiens ANKRD26 gene for ankyrin repeat domain-containing protein 26, complete cds, without stop codon, in Flexi system.
LF365354 - JP 2014500723-A/172857: Polycomb-Associated Non-Coding RNAs.
LF365355 - JP 2014500723-A/172858: Polycomb-Associated Non-Coding RNAs.
LF365356 - JP 2014500723-A/172859: Polycomb-Associated Non-Coding RNAs.
LF365357 - JP 2014500723-A/172860: Polycomb-Associated Non-Coding RNAs.
LF365358 - JP 2014500723-A/172861: Polycomb-Associated Non-Coding RNAs.
LF365359 - JP 2014500723-A/172862: Polycomb-Associated Non-Coding RNAs.
LF365360 - JP 2014500723-A/172863: Polycomb-Associated Non-Coding RNAs.
LF365361 - JP 2014500723-A/172864: Polycomb-Associated Non-Coding RNAs.
LF365362 - JP 2014500723-A/172865: Polycomb-Associated Non-Coding RNAs.
LF365363 - JP 2014500723-A/172866: Polycomb-Associated Non-Coding RNAs.
LF365364 - JP 2014500723-A/172867: Polycomb-Associated Non-Coding RNAs.
LF365365 - JP 2014500723-A/172868: Polycomb-Associated Non-Coding RNAs.
LF365366 - JP 2014500723-A/172869: Polycomb-Associated Non-Coding RNAs.
LF365367 - JP 2014500723-A/172870: Polycomb-Associated Non-Coding RNAs.
LF365368 - JP 2014500723-A/172871: Polycomb-Associated Non-Coding RNAs.
LF365370 - JP 2014500723-A/172873: Polycomb-Associated Non-Coding RNAs.
LF365371 - JP 2014500723-A/172874: Polycomb-Associated Non-Coding RNAs.
DQ577672 - Homo sapiens piRNA piR-45784, complete sequence.
LF365374 - JP 2014500723-A/172877: Polycomb-Associated Non-Coding RNAs.
AK001137 - Homo sapiens cDNA FLJ10275 fis, clone HEMBB1001175, weakly similar to ANKYRIN.
LF365375 - JP 2014500723-A/172878: Polycomb-Associated Non-Coding RNAs.
LF365376 - JP 2014500723-A/172879: Polycomb-Associated Non-Coding RNAs.
LF365378 - JP 2014500723-A/172881: Polycomb-Associated Non-Coding RNAs.
KY966267 - Homo sapiens cell line 95T1000 GNS/ANKRD26/NCKAP1L fusion mRNA, partial sequence.
DQ586806 - Homo sapiens piRNA piR-53918, complete sequence.
LF365381 - JP 2014500723-A/172884: Polycomb-Associated Non-Coding RNAs.
LF365383 - JP 2014500723-A/172886: Polycomb-Associated Non-Coding RNAs.
MA619755 - JP 2018138019-A/191681: Polycomb-Associated Non-Coding RNAs.
MA600929 - JP 2018138019-A/172855: Polycomb-Associated Non-Coding RNAs.
MA600931 - JP 2018138019-A/172857: Polycomb-Associated Non-Coding RNAs.
MA600932 - JP 2018138019-A/172858: Polycomb-Associated Non-Coding RNAs.
MA600933 - JP 2018138019-A/172859: Polycomb-Associated Non-Coding RNAs.
MA600934 - JP 2018138019-A/172860: Polycomb-Associated Non-Coding RNAs.
MA600935 - JP 2018138019-A/172861: Polycomb-Associated Non-Coding RNAs.
MA600936 - JP 2018138019-A/172862: Polycomb-Associated Non-Coding RNAs.
MA600937 - JP 2018138019-A/172863: Polycomb-Associated Non-Coding RNAs.
MA600938 - JP 2018138019-A/172864: Polycomb-Associated Non-Coding RNAs.
MA600939 - JP 2018138019-A/172865: Polycomb-Associated Non-Coding RNAs.
MA600940 - JP 2018138019-A/172866: Polycomb-Associated Non-Coding RNAs.
MA600941 - JP 2018138019-A/172867: Polycomb-Associated Non-Coding RNAs.
MA600942 - JP 2018138019-A/172868: Polycomb-Associated Non-Coding RNAs.
MA600943 - JP 2018138019-A/172869: Polycomb-Associated Non-Coding RNAs.
MA600944 - JP 2018138019-A/172870: Polycomb-Associated Non-Coding RNAs.
MA600945 - JP 2018138019-A/172871: Polycomb-Associated Non-Coding RNAs.
MA600947 - JP 2018138019-A/172873: Polycomb-Associated Non-Coding RNAs.
MA600948 - JP 2018138019-A/172874: Polycomb-Associated Non-Coding RNAs.
MA600951 - JP 2018138019-A/172877: Polycomb-Associated Non-Coding RNAs.
MA600952 - JP 2018138019-A/172878: Polycomb-Associated Non-Coding RNAs.
MA600953 - JP 2018138019-A/172879: Polycomb-Associated Non-Coding RNAs.
MA600955 - JP 2018138019-A/172881: Polycomb-Associated Non-Coding RNAs.
MA600958 - JP 2018138019-A/172884: Polycomb-Associated Non-Coding RNAs.
MA600960 - JP 2018138019-A/172886: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NH29, ANKRD26 , ANR26_HUMAN, ENST00000376087.1, ENST00000376087.2, ENST00000376087.3, ENST00000376087.4, KIAA1074, NM_014915, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69, Q9UPS8, uc318msi.1, uc318msi.2
UCSC ID: ENST00000376087.5_9
RefSeq Accession: NM_014915.3
Protein: Q9UPS8 (aka ANR26_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene ANKRD26:
ankrd26 (ANKRD26-Related Thrombocytopenia)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.