Human Gene ANKRD52 (ENST00000267116.8_7) from GENCODE V47lift37
  Description: ankyrin repeat domain 52 (from RefSeq NM_173595.4)
Gencode Transcript: ENST00000267116.8_7
Gencode Gene: ENSG00000139645.11_10
Transcript (Including UTRs)
   Position: hg19 chr12:56,631,591-56,652,168 Size: 20,578 Total Exon Count: 28 Strand: -
Coding Region
   Position: hg19 chr12:56,636,926-56,652,053 Size: 15,128 Coding Exon Count: 28 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:56,631,591-56,652,168)mRNA (may differ from genome)Protein (1076 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ANR52_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Short=PP6-ARS-C; Short=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C; AltName: Full=Ankyrin repeat domain-containing protein 52;
FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.
SUBUNIT: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.
SIMILARITY: Contains 28 ANK repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.46 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 264.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.50115-0.491 Picture PostScript Text
3' UTR -2097.705335-0.393 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF00023 - Ankyrin repeat
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
51984 - MurCD N-terminal domain
56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on Q8NB46
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  AK056831 - Homo sapiens cDNA FLJ32269 fis, clone PROST1000526.
BC042070 - Homo sapiens ankyrin repeat domain 52, mRNA (cDNA clone IMAGE:5738580).
AB190990 - Homo sapiens ANKRD33 mRNA for ankyrin repeat domain 33, complete cds.
AY358160 - Homo sapiens clone DNA131636 CVWG5837 (UNQ5837) mRNA, complete cds.
AK125379 - Homo sapiens cDNA FLJ43389 fis, clone OCBBF2007068, highly similar to Ankyrin repeat domain-containing protein 52.
BC024309 - Homo sapiens ankyrin repeat domain 52, mRNA (cDNA clone IMAGE:4905854), with apparent retained intron.
BC036946 - Homo sapiens cDNA clone IMAGE:5393851, **** WARNING: chimeric clone ****.
AK091555 - Homo sapiens cDNA FLJ34236 fis, clone FCBBF3027199.
AX747058 - Sequence 583 from Patent EP1308459.
AK126893 - Homo sapiens cDNA FLJ44945 fis, clone BRAMY4001652, weakly similar to Ankyrin 1.
JD122504 - Sequence 103528 from Patent EP1572962.
JD164648 - Sequence 145672 from Patent EP1572962.
JD232483 - Sequence 213507 from Patent EP1572962.
JD353383 - Sequence 334407 from Patent EP1572962.
JD154486 - Sequence 135510 from Patent EP1572962.
JD477876 - Sequence 458900 from Patent EP1572962.
JD445818 - Sequence 426842 from Patent EP1572962.
JD484904 - Sequence 465928 from Patent EP1572962.
JD137925 - Sequence 118949 from Patent EP1572962.
JD039722 - Sequence 20746 from Patent EP1572962.
JD311297 - Sequence 292321 from Patent EP1572962.
JD449870 - Sequence 430894 from Patent EP1572962.
JD488894 - Sequence 469918 from Patent EP1572962.
JD340531 - Sequence 321555 from Patent EP1572962.
LF362125 - JP 2014500723-A/169628: Polycomb-Associated Non-Coding RNAs.
MA597702 - JP 2018138019-A/169628: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NE79, ANR52_HUMAN, B1Q2K2, ENST00000267116.1, ENST00000267116.2, ENST00000267116.3, ENST00000267116.4, ENST00000267116.5, ENST00000267116.6, ENST00000267116.7, NM_173595, Q8NB46, uc317ijo.1, uc317ijo.2
UCSC ID: ENST00000267116.8_7
RefSeq Accession: NM_173595.4
Protein: Q8NB46 (aka ANR52_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.