ID:AN32A_HUMAN DESCRIPTION: RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member A; AltName: Full=Acidic nuclear phosphoprotein pp32; AltName: Full=Leucine-rich acidic nuclear protein; Short=LANP; AltName: Full=Mapmodulin; AltName: Full=Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; AltName: Full=Putative HLA-DR-associated protein I; Short=PHAPI; FUNCTION: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. SUBUNIT: Component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B (By similarity). Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1. INTERACTION: O15169:AXIN1; NbExp=2; IntAct=EBI-359234, EBI-710484; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. TISSUE SPECIFICITY: Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala. PTM: Phosphorylated on serine residues. PTM: The N-terminus is blocked. PTM: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity). SIMILARITY: Belongs to the ANP32 family. SIMILARITY: Contains 4 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain. SEQUENCE CAUTION: Sequence=BAD97000.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P39687
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AY007110 - Homo sapiens clone TCCCTA00084 mRNA sequence. AK223280 - Homo sapiens mRNA for acidic (leucine-rich) nuclear phosphoprotein 32 family, member A variant, clone: SYN03039. BC007200 - Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member A, mRNA (cDNA clone MGC:12667 IMAGE:3677623), complete cds. GQ900908 - Homo sapiens clone HEL-T-20 epididymis secretory sperm binding protein mRNA, complete cds. AK127498 - Homo sapiens cDNA FLJ45591 fis, clone BRTHA3014835. U73477 - Human acidic nuclear phosphoprotein pp32 mRNA, complete cds. X75090 - H.sapiens mRNA for HLA-DR associated protein I (PHAPI). AF025684 - Homo sapiens cerebellar leucine rich acidic nuclear protein (LANP) mRNA, complete cds. AY349171 - Homo sapiens inhibitor-1 of protein phosphatase-2A mRNA, complete cds. U60823 - Human potent heat-stable protein phosphatase 2A inhibitor I1PP2A mRNA, complete cds. AK312703 - Homo sapiens cDNA, FLJ93102, Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32family, member A (ANP32A), mRNA. BT007436 - Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member A mRNA, complete cds. DQ893294 - Synthetic construct clone IMAGE:100005924; FLH199488.01X; RZPDo839D0882D acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A) gene, encodes complete protein. DQ896729 - Synthetic construct Homo sapiens clone IMAGE:100011189; FLH199394.01L; RZPDo839D0881D acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A) gene, encodes complete protein. AB463390 - Synthetic construct DNA, clone: pF1KB7264, Homo sapiens ANP32A gene for acidic (leucine-rich) nuclear phosphoprotein 32 family, member A, without stop codon, in Flexi system. BC125143 - Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member A, mRNA (cDNA clone MGC:150373 IMAGE:40119966), complete cds. KJ901861 - Synthetic construct Homo sapiens clone ccsbBroadEn_11255 ANP32A gene, encodes complete protein. BC000608 - Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member A, mRNA (cDNA clone IMAGE:3346215), partial cds. JD496590 - Sequence 477614 from Patent EP1572962. JD266882 - Sequence 247906 from Patent EP1572962. JD496210 - Sequence 477234 from Patent EP1572962. BC064969 - Homo sapiens cDNA clone IMAGE:6149643, partial cds. JD500909 - Sequence 481933 from Patent EP1572962. JD356895 - Sequence 337919 from Patent EP1572962. JD513179 - Sequence 494203 from Patent EP1572962. JD026496 - Sequence 7520 from Patent EP1572962. JD031143 - Sequence 12167 from Patent EP1572962. LF341498 - JP 2014500723-A/149001: Polycomb-Associated Non-Coding RNAs. JD306889 - Sequence 287913 from Patent EP1572962. MA577075 - JP 2018138019-A/149001: Polycomb-Associated Non-Coding RNAs. JD341260 - Sequence 322284 from Patent EP1572962. JD138777 - Sequence 119801 from Patent EP1572962. JD056776 - Sequence 37800 from Patent EP1572962. JD177946 - Sequence 158970 from Patent EP1572962. JD539272 - Sequence 520296 from Patent EP1572962. JD178728 - Sequence 159752 from Patent EP1572962. JD477427 - Sequence 458451 from Patent EP1572962. JD496719 - Sequence 477743 from Patent EP1572962. BC106719 - Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member A, mRNA (cDNA clone MGC:119787 IMAGE:40014106), complete cds. JD260681 - Sequence 241705 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_setPathway - Granzyme A mediated Apoptosis Pathway
Reactome (by CSHL, EBI, and GO)
Protein P39687 (Reactome details) participates in the following event(s):
R-HSA-450387 HuR binds the CRM1 nuclear export machinery R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
