ID:AN32B_HUMAN DESCRIPTION: RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member B; AltName: Full=Acidic protein rich in leucines; AltName: Full=Putative HLA-DR-associated protein I-2; Short=PHAPI2; AltName: Full=Silver-stainable protein SSP29; FUNCTION: Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome. SUBUNIT: Monomer. Interacts with histones H3 and H4. SUBCELLULAR LOCATION: Isoform 1: Nucleus. Note=Accumulates in the nuclei at the S phase (By similarity). SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Note=Lacks a nuclear localization signal. TISSUE SPECIFICITY: Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. DOMAIN: Histone binding is mediated by the concave surface of the LRR region. PTM: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity). SIMILARITY: Belongs to the ANP32 family. SIMILARITY: Contains 4 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92688
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001944 vasculature development GO:0006334 nucleosome assembly GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0021591 ventricular system development GO:0043486 histone exchange GO:0045596 negative regulation of cell differentiation GO:0046827 positive regulation of protein export from nucleus GO:0048839 inner ear development GO:0060021 palate development
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
