ID:ANXA2_HUMAN DESCRIPTION: RecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36; FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. SUBUNIT: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with human cytomegalovirus (HCMV). Interacts with COCH. INTERACTION: P40692:MLH1; NbExp=7; IntAct=EBI-352622, EBI-744248; SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid. PTM: Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. PTM: ISGylated. MISCELLANEOUS: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. SIMILARITY: Belongs to the annexin family. SIMILARITY: Contains 4 annexin repeats. SEQUENCE CAUTION: Sequence=AAH66955.2; Type=Erroneous initiation; WEB RESOURCE: Name=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/sptlt086.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P07355
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0002020 protease binding GO:0003723 RNA binding GO:0004859 phospholipase inhibitor activity GO:0005509 calcium ion binding GO:0005515 protein binding GO:0005544 calcium-dependent phospholipid binding GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0008092 cytoskeletal protein binding GO:0017137 Rab GTPase binding GO:0019834 phospholipase A2 inhibitor activity GO:0042802 identical protein binding GO:0044548 S100 protein binding GO:0044730 bone sialoprotein binding GO:0048306 calcium-dependent protein binding GO:0098641 cadherin binding involved in cell-cell adhesion GO:0098772 molecular function regulator
Biological Process: GO:0001525 angiogenesis GO:0001765 membrane raft assembly GO:0001921 positive regulation of receptor recycling GO:0001934 positive regulation of protein phosphorylation GO:0006900 membrane budding GO:0007589 body fluid secretion GO:0030199 collagen fibril organization GO:0031340 positive regulation of vesicle fusion GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process GO:0035722 interleukin-12-mediated signaling pathway GO:0036035 osteoclast development GO:0042730 fibrinolysis GO:0043086 negative regulation of catalytic activity GO:0043312 neutrophil degranulation GO:0044090 positive regulation of vacuole organization GO:0044147 negative regulation of development of symbiont involved in interaction with host GO:0048146 positive regulation of fibroblast proliferation GO:0051099 positive regulation of binding GO:0051290 protein heterotetramerization GO:0052362 catabolism by host of symbiont protein GO:0052405 negative regulation by host of symbiont molecular function GO:0072659 protein localization to plasma membrane GO:0097066 response to thyroid hormone GO:0098609 cell-cell adhesion GO:1905581 positive regulation of low-density lipoprotein particle clearance GO:1905597 positive regulation of low-density lipoprotein particle receptor binding GO:1905599 positive regulation of low-density lipoprotein receptor activity GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
