Human Gene ANXA5 (ENST00000296511.10_7) from GENCODE V47lift37
  Description: annexin A5 (from RefSeq NM_001154.4)
Gencode Transcript: ENST00000296511.10_7
Gencode Gene: ENSG00000164111.15_9
Transcript (Including UTRs)
   Position: hg19 chr4:122,589,101-122,618,135 Size: 29,035 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr4:122,589,623-122,617,744 Size: 28,122 Coding Exon Count: 12 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:122,589,101-122,618,135)mRNA (may differ from genome)Protein (320 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ANXA5
Diseases sorted by gene-association score: pregnancy loss, recurrent 3* (594), pregnancy loss, recurrent, susceptibility 3* (100), antiphospholipid syndrome (15), overhydrated hereditary stomatocytosis (11), indolent myeloma (8), myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency (7), barth syndrome (6), israeli tick typhus (6), cerebral neuroblastoma (5), transposition of the great arteries (4), gnathomiasis (4), small cell sarcoma (4), cardiomyopathy, hypertrophic, 2 (4), growth hormone deficiency, isolated, type ii (4), colon adenocarcinoma (4), central nervous system tuberculosis (4), amyotrophic lateral sclerosis type 10 (3), pancreatic cancer (3), lung cancer (3), colorectal cancer (2), myelodysplastic syndrome (2), chronic lymphocytic leukemia (2), uveal melanoma (2), ovarian cancer, somatic (2), leukemia, chronic myeloid, somatic (2), prostate cancer (2), squamous cell carcinoma, head and neck (2), myocardial infarction (1), osteosarcoma, somatic (1), gastrointestinal system cancer (1), lymphoma, non-hodgkin (1), leukemia, acute myeloid (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 531.36 RPKM in Cells - Cultured fibroblasts
Total median expression: 7101.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.60153-0.357 Picture PostScript Text
3' UTR -99.50522-0.191 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  BC001429 - Homo sapiens annexin A5, mRNA (cDNA clone MGC:2261 IMAGE:3140878), complete cds.
BC032093 - Homo sapiens annexin A5, mRNA (cDNA clone IMAGE:3924873).
EU794590 - Homo sapiens epididymis secretory protein Li 7 (HEL-S-7) mRNA, complete cds.
BC018671 - Homo sapiens annexin A5, mRNA (cDNA clone MGC:27177 IMAGE:4252480), complete cds.
M18366 - Human placental anticoagulant protein (PAP) mRNA, complete cds.
X12454 - Human mRNA for vascular anticoagulant.
D00172 - Homo sapiens mRNA for blood coagulation inhibitor, complete cds.
E01816 - cDNA encoding human anticoagulant.
E03096 - DNA encoding calphobindin(CPB-I).
M19384 - Human placenta anticoagulant protein PP4 mRNA, complete cds.
J03745 - Human endonexin II mRNA, complete cds.
M21731 - Human lipocortin-V mRNA, complete cds.
BC012804 - Homo sapiens annexin A5, mRNA (cDNA clone MGC:2795 IMAGE:2961097), complete cds.
BC012822 - Homo sapiens annexin A5, mRNA (cDNA clone MGC:4465 IMAGE:2961097), complete cds.
BC004993 - Homo sapiens annexin A5, mRNA (cDNA clone MGC:4402 IMAGE:2906015), complete cds.
JD302698 - Sequence 283722 from Patent EP1572962.
JD287753 - Sequence 268777 from Patent EP1572962.
JD427792 - Sequence 408816 from Patent EP1572962.
JD214480 - Sequence 195504 from Patent EP1572962.
AY577779 - Homo sapiens annexin V-like mRNA, complete sequence.
CR536522 - Homo sapiens full open reading frame cDNA clone RZPDo834B1220D for gene ANXA5, annexin A5; complete cds, incl. stopcodon.
AK312644 - Homo sapiens cDNA, FLJ93030, Homo sapiens annexin A5 (ANXA5), mRNA.
DQ891944 - Synthetic construct Homo sapiens clone IMAGE:100004574; FLH263565.01X; RZPDo839F09136D annexin A5 (ANXA5) gene, encodes complete protein.
EU176318 - Synthetic construct Homo sapiens clone IMAGE:100006561; FLH263566.01X; RZPDo839H02135D annexin A5 (ANXA5) gene, encodes complete protein.
KJ890676 - Synthetic construct Homo sapiens clone ccsbBroadEn_00070 ANXA5 gene, encodes complete protein.
KJ896432 - Synthetic construct Homo sapiens clone ccsbBroadEn_05826 ANXA5 gene, encodes complete protein.
EU176660 - Synthetic construct Homo sapiens clone IMAGE:100011452; FLH181788.01L; RZPDo839B12254D annexin A5 (ANXA5) gene, encodes complete protein.
AB528061 - Synthetic construct DNA, clone: pF1KE0213, Homo sapiens ANXA5 gene for annexin A5, without stop codon, in Flexi system.
AM393144 - Synthetic construct Homo sapiens clone IMAGE:100002545 for hypothetical protein (ANXA5 gene).
CR541842 - Homo sapiens full open reading frame cDNA clone RZPDo834A1232D for gene ANXA5, annexin A5; complete cds, without stopcodon.
CU676274 - Synthetic construct Homo sapiens gateway clone IMAGE:100023395 5' read ANXA5 mRNA.
AK297909 - Homo sapiens cDNA FLJ52002 complete cds, highly similar to Annexin A5.
CU678846 - Synthetic construct Homo sapiens gateway clone IMAGE:100018905 5' read ANXA5 mRNA.
JD487751 - Sequence 468775 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000296511.1, ENST00000296511.2, ENST00000296511.3, ENST00000296511.4, ENST00000296511.5, ENST00000296511.6, ENST00000296511.7, ENST00000296511.8, ENST00000296511.9, HEL-S-7 , NM_001154, uc317lul.1, uc317lul.2, V9HWE0, V9HWE0_HUMAN
UCSC ID: ENST00000296511.10_7
RefSeq Accession: NM_001154.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.