ID:AP2A1_HUMAN DESCRIPTION: RecName: Full=AP-2 complex subunit alpha-1; AltName: Full=100 kDa coated vesicle protein A; AltName: Full=Adapter-related protein complex 2 alpha-1 subunit; AltName: Full=Adaptor protein complex AP-2 subunit alpha-1; AltName: Full=Alpha-adaptin A; AltName: Full=Alpha1-adaptin; AltName: Full=Clathrin assembly protein complex 2 alpha-A large chain; AltName: Full=Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit; FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C- terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). SUBUNIT: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with SGIP1 (By similarity). Interacts with HIP1 and RAB11FIP2. Interacts with SLC12A5. Interacts with clathrin. SUBCELLULAR LOCATION: Cell membrane (By similarity). Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV (By similarity). TISSUE SPECIFICITY: Isoform A expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B is widely expressed in tissues and also in breast cancer and in prostate carcinoma cells. SIMILARITY: Belongs to the adaptor complexes large subunit family. SEQUENCE CAUTION: Sequence=AAD15564.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95782
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0019901 protein kinase binding GO:0035615 clathrin adaptor activity GO:0044877 macromolecular complex binding GO:0050750 low-density lipoprotein particle receptor binding
Biological Process: GO:0006886 intracellular protein transport GO:0006895 Golgi to endosome transport GO:0006897 endocytosis GO:0010976 positive regulation of neuron projection development GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0032802 low-density lipoprotein particle receptor catabolic process GO:0034383 low-density lipoprotein particle clearance GO:0048013 ephrin receptor signaling pathway GO:0048260 positive regulation of receptor-mediated endocytosis GO:0050690 regulation of defense response to virus by virus GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0061024 membrane organization GO:0072583 clathrin-dependent endocytosis GO:1900126 negative regulation of hyaluronan biosynthetic process
AK302005 - Homo sapiens cDNA FLJ61453 complete cds, highly similar to Adapter-relatedprotein complex 2 alpha- 1 subunit. AK124343 - Homo sapiens cDNA FLJ42352 fis, clone UTERU2006115, highly similar to ALPHA-ADAPTIN A. BC014214 - Homo sapiens adaptor-related protein complex 2, alpha 1 subunit, mRNA (cDNA clone MGC:20679 IMAGE:4111165), complete cds. JD521758 - Sequence 502782 from Patent EP1572962. JD560847 - Sequence 541871 from Patent EP1572962. AL136925 - Homo sapiens mRNA; cDNA DKFZp586H1320 (from clone DKFZp586H1320). JD335766 - Sequence 316790 from Patent EP1572962. JD405420 - Sequence 386444 from Patent EP1572962. DQ892253 - Synthetic construct clone IMAGE:100004883; FLH184557.01X; RZPDo839H03144D adaptor-related protein complex 2, alpha 1 subunit (AP2A1) gene, encodes complete protein. DQ895454 - Synthetic construct Homo sapiens clone IMAGE:100009914; FLH184553.01L; RZPDo839H03143D adaptor-related protein complex 2, alpha 1 subunit (AP2A1) gene, encodes complete protein. CU676931 - Synthetic construct Homo sapiens gateway clone IMAGE:100020739 5' read AP2A1 mRNA. AB527855 - Synthetic construct DNA, clone: pF1KB8539, Homo sapiens AP2A1 gene for adaptor-related protein complex 2, alpha 1 subunit, without stop codon, in Flexi system. KJ905137 - Synthetic construct Homo sapiens clone ccsbBroadEn_14534 AP2A1-like gene, encodes complete protein. KX018644 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 5 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018645 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 6 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018646 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 7 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018647 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 8 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018648 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 9 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018649 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 10 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018650 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 11 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018651 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 12 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018652 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 13 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018653 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 14 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018654 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 15 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018655 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 16 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018656 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 17 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018657 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 18 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018658 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 19 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018659 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 20 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018660 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 21 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018661 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 22 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018662 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 23 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018663 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 24 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018664 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 25 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018665 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 26 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018666 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 27 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018667 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 28 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018668 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 29 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018669 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 30 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018670 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 31 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018671 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 32 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018672 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 33 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018673 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 34 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018674 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 35 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018675 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 36 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018676 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 37 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018677 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 38 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018678 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 39 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018679 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 40 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018680 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 41 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018681 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 42 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018682 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 43 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018683 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 44 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018684 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 45 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018685 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 46 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018686 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 47 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018687 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 48 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018688 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 49 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018689 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 50 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018690 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 51 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018691 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 52 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018692 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 53 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018693 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 54 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018694 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 55 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018695 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 56 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018696 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 57 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018697 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 58 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018698 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 59 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018699 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 60 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018700 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 61 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018701 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 62 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018702 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 63 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018703 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 64 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018704 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 65 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018705 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 66 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018706 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 67 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018707 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 68 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018708 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 69 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018709 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 70 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018710 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 71 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018711 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 72 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018712 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 73 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018713 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 74 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018714 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 75 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018715 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 76 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018716 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 77 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018717 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 78 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018718 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 79 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018719 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 80 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018720 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 81 (AP2A1) mRNA, partial sequence; alternatively spliced. AK094317 - Homo sapiens cDNA FLJ36998 fis, clone BRACE2007295, highly similar to ALPHA-ADAPTIN A. AK090661 - Homo sapiens cDNA FLJ33342 fis, clone BRACE2002834, moderately similar to ALPHA-ADAPTIN A. AK096757 - Homo sapiens cDNA FLJ39438 fis, clone PROST2005076. JD495984 - Sequence 477008 from Patent EP1572962. JD157804 - Sequence 138828 from Patent EP1572962. JD185671 - Sequence 166695 from Patent EP1572962. JD490356 - Sequence 471380 from Patent EP1572962. JD294633 - Sequence 275657 from Patent EP1572962. JD205123 - Sequence 186147 from Patent EP1572962. JD127218 - Sequence 108242 from Patent EP1572962. JD389445 - Sequence 370469 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_bArrestinPathway - ¿-arrestins in GPCR Desensitization h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_ptdinsPathway - Phosphoinositides and their downstream targets.
Reactome (by CSHL, EBI, and GO)
Protein O95782 (Reactome details) participates in the following event(s):
R-HSA-421007 Endocytosis of Ca impermeable AMPA receptors R-HSA-443783 Interaction of NUMB with L1 R-HSA-167537 Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex R-HSA-182186 Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex R-HSA-8856808 Recruitment of AP-2 complex and clathrin R-HSA-8866277 AP-2 directly binds some endocytic cargo R-HSA-8871196 Initial binding of AP-2 and clathrin to PI(4,5)P2 R-HSA-416639 Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites R-HSA-177491 Formation of clathrin-coated vesicle R-HSA-392748 L1 binds to AP-2 Clathrin complex R-HSA-2130640 Recruitment of clathrin coated vesicle by Ii R-HSA-6784735 PCSK9:LDLR bind to Clathrin R-HSA-8855131 VLDLR:PCSK9 binds Clathrin-coated vesicles R-HSA-445071 Reinsertion of L1 into the plasma membrane R-HSA-167597 Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex R-HSA-182198 Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex R-HSA-5138433 p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis R-HSA-8856813 AAK1 phosphorylates AP-2 mu subunit at T156 R-HSA-8862280 FCHo proteins bind nascent clathrin-coated pit R-HSA-8866283 ARBB recruits GPCRs into clathrin-coated pits R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit R-HSA-8871194 RAB5 and GAPVD1 bind AP-2 R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P R-HSA-2130486 Uncoating of clathrin-coated vesicles and fusion with endosomes R-HSA-177479 Axonal transport of NGF:Trk complexes R-HSA-177501 Endocytosis (internalization) of clathrin-coated vesicle R-HSA-374696 Phosphorylation of L1 by p90rsk R-HSA-392749 Transport of L1 into endosomes R-HSA-555065 Formation of clathrin coated vesicle R-HSA-445077 Transport of L1 from C-domain to P-domain R-HSA-445079 Phosphorylation of L1 by ERK R-HSA-6784729 PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome R-HSA-8868071 Clathrin recruits PIK3C2A R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit R-HSA-8866279 Epsin family proteins bind ubiquitinated cargo R-HSA-8868236 BAR domain proteins recruit dynamin R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit R-HSA-416993 Trafficking of GluR2-containing AMPA receptors R-HSA-437239 Recycling pathway of L1 R-HSA-167590 Nef Mediated CD4 Down-regulation R-HSA-182218 Nef Mediated CD8 Down-regulation R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-399719 Trafficking of AMPA receptors R-HSA-177504 Retrograde neurotrophin signalling R-HSA-2132295 MHC class II antigen presentation R-HSA-8964038 LDL clearance R-HSA-8866427 VLDLR internalisation and degradation R-HSA-373760 L1CAM interactions R-HSA-5099900 WNT5A-dependent internalization of FZD4 R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-2682334 EPH-Ephrin signaling R-HSA-199991 Membrane Trafficking R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-187037 Signaling by NTRK1 (TRKA) R-HSA-1280218 Adaptive Immune System R-HSA-8964043 Plasma lipoprotein clearance R-HSA-422475 Axon guidance R-HSA-4086400 PCP/CE pathway R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-5653656 Vesicle-mediated transport R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-166520 Signaling by NTRKs R-HSA-168256 Immune System R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance R-HSA-1266738 Developmental Biology R-HSA-3858494 Beta-catenin independent WNT signaling R-HSA-162909 Host Interactions of HIV factors R-HSA-112315 Transmission across Chemical Synapses R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-382551 Transport of small molecules R-HSA-195721 Signaling by WNT R-HSA-162906 HIV Infection R-HSA-112316 Neuronal System R-HSA-162582 Signal Transduction R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
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Common Gene Haplotype Alleles 
