ID:AP3M1_HUMAN DESCRIPTION: RecName: Full=AP-3 complex subunit mu-1; AltName: Full=AP-3 adapter complex mu3A subunit; AltName: Full=Adapter-related protein complex 3 mu-1 subunit; AltName: Full=Mu-adaptin 3A; AltName: Full=Mu3A-adaptin; FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. SUBUNIT: Adaptor protein complex 3 (AP-3) is an heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta- type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity). SUBCELLULAR LOCATION: Golgi apparatus. SIMILARITY: Belongs to the adaptor complexes medium subunit family. SIMILARITY: Contains 1 MHD (mu homology) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00928 - Adaptor complexes medium subunit family PF01217 - Clathrin adaptor complex small chain
SCOP Domains: 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor 64356 - SNARE-like
ModBase Predicted Comparative 3D Structure on Q9Y2T2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006622 protein targeting to lysosome GO:0006886 intracellular protein transport GO:0008089 anterograde axonal transport GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0048490 anterograde synaptic vesicle transport
LF209954 - JP 2014500723-A/17457: Polycomb-Associated Non-Coding RNAs. LF209955 - JP 2014500723-A/17458: Polycomb-Associated Non-Coding RNAs. BC067127 - Homo sapiens adaptor-related protein complex 3, mu 1 subunit, mRNA (cDNA clone MGC:75195 IMAGE:6169822), complete cds. AK026983 - Homo sapiens cDNA: FLJ23330 fis, clone HEP12654. AL833820 - Homo sapiens mRNA; cDNA DKFZp586G1518 (from clone DKFZp586G1518). BC026232 - Homo sapiens adaptor-related protein complex 3, mu 1 subunit, mRNA (cDNA clone MGC:22164 IMAGE:4807259), complete cds. AK299352 - Homo sapiens cDNA FLJ51284 complete cds, highly similar to Adapter-relatedprotein complex 3 mu-1 subunit. AF092092 - Homo sapiens AP-3 adaptor complex mu3A subunit mRNA, complete cds. AK315597 - Homo sapiens cDNA, FLJ96676. KJ893584 - Synthetic construct Homo sapiens clone ccsbBroadEn_02978 AP3M1 gene, encodes complete protein. DQ893112 - Synthetic construct clone IMAGE:100005742; FLH193850.01X; RZPDo839C0979D adaptor-related protein complex 3, mu 1 subunit (AP3M1) gene, encodes complete protein. DQ896386 - Synthetic construct Homo sapiens clone IMAGE:100010846; FLH193846.01L; RZPDo839C0969D adaptor-related protein complex 3, mu 1 subunit (AP3M1) gene, encodes complete protein. EU176768 - Synthetic construct Homo sapiens clone IMAGE:100011584; FLH263630.01L; RZPDo839H02256D adaptor-related protein complex 3, mu 1 subunit (AP3M1) gene, encodes complete protein. AB529047 - Synthetic construct DNA, clone: pF1KB3614, Homo sapiens AP3M1 gene for adaptor-related protein complex 3, mu 1 subunit, without stop codon, in Flexi system. CU688256 - Synthetic construct Homo sapiens gateway clone IMAGE:100021759 5' read AP3M1 mRNA. MA445531 - JP 2018138019-A/17457: Polycomb-Associated Non-Coding RNAs. MA445532 - JP 2018138019-A/17458: Polycomb-Associated Non-Coding RNAs. AK001565 - Homo sapiens cDNA FLJ10703 fis, clone NT2RP3000836. JD243163 - Sequence 224187 from Patent EP1572962. JD545812 - Sequence 526836 from Patent EP1572962. JD363138 - Sequence 344162 from Patent EP1572962. JD238307 - Sequence 219331 from Patent EP1572962. JD135717 - Sequence 116741 from Patent EP1572962. JD378218 - Sequence 359242 from Patent EP1572962. JD144589 - Sequence 125613 from Patent EP1572962. JD283318 - Sequence 264342 from Patent EP1572962. JD112299 - Sequence 93323 from Patent EP1572962. JD144588 - Sequence 125612 from Patent EP1572962. JD089486 - Sequence 70510 from Patent EP1572962. JD112298 - Sequence 93322 from Patent EP1572962. JD188045 - Sequence 169069 from Patent EP1572962. LF333243 - JP 2014500723-A/140746: Polycomb-Associated Non-Coding RNAs. AL133610 - Homo sapiens mRNA; cDNA DKFZp434M2217 (from clone DKFZp434M2217). JD315585 - Sequence 296609 from Patent EP1572962. JD282306 - Sequence 263330 from Patent EP1572962. JD256199 - Sequence 237223 from Patent EP1572962. JD040652 - Sequence 21676 from Patent EP1572962. JD379938 - Sequence 360962 from Patent EP1572962. JD038971 - Sequence 19995 from Patent EP1572962. JD537045 - Sequence 518069 from Patent EP1572962. JD109866 - Sequence 90890 from Patent EP1572962. JD085928 - Sequence 66952 from Patent EP1572962. JD166869 - Sequence 147893 from Patent EP1572962. JD251745 - Sequence 232769 from Patent EP1572962. JD328811 - Sequence 309835 from Patent EP1572962. JD122391 - Sequence 103415 from Patent EP1572962. JD378506 - Sequence 359530 from Patent EP1572962. LF333244 - JP 2014500723-A/140747: Polycomb-Associated Non-Coding RNAs. JD399711 - Sequence 380735 from Patent EP1572962. JD566256 - Sequence 547280 from Patent EP1572962. JD564837 - Sequence 545861 from Patent EP1572962. LF333245 - JP 2014500723-A/140748: Polycomb-Associated Non-Coding RNAs. JD108423 - Sequence 89447 from Patent EP1572962. JD275218 - Sequence 256242 from Patent EP1572962. JD160450 - Sequence 141474 from Patent EP1572962. LF333246 - JP 2014500723-A/140749: Polycomb-Associated Non-Coding RNAs. JD427069 - Sequence 408093 from Patent EP1572962. LF333247 - JP 2014500723-A/140750: Polycomb-Associated Non-Coding RNAs. JD279998 - Sequence 261022 from Patent EP1572962. JD074251 - Sequence 55275 from Patent EP1572962. JD188449 - Sequence 169473 from Patent EP1572962. LF333248 - JP 2014500723-A/140751: Polycomb-Associated Non-Coding RNAs. JD348156 - Sequence 329180 from Patent EP1572962. JD203020 - Sequence 184044 from Patent EP1572962. LF333250 - JP 2014500723-A/140753: Polycomb-Associated Non-Coding RNAs. MA568820 - JP 2018138019-A/140746: Polycomb-Associated Non-Coding RNAs. MA568821 - JP 2018138019-A/140747: Polycomb-Associated Non-Coding RNAs. MA568822 - JP 2018138019-A/140748: Polycomb-Associated Non-Coding RNAs. MA568823 - JP 2018138019-A/140749: Polycomb-Associated Non-Coding RNAs. MA568824 - JP 2018138019-A/140750: Polycomb-Associated Non-Coding RNAs. MA568825 - JP 2018138019-A/140751: Polycomb-Associated Non-Coding RNAs. MA568827 - JP 2018138019-A/140753: Polycomb-Associated Non-Coding RNAs. LF333251 - JP 2014500723-A/140754: Polycomb-Associated Non-Coding RNAs. MA568828 - JP 2018138019-A/140754: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y2T2 (Reactome details) participates in the following event(s):
R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
