ID:API5_HUMAN DESCRIPTION: RecName: Full=Apoptosis inhibitor 5; Short=API-5; AltName: Full=Antiapoptosis clone 11 protein; Short=AAC-11; AltName: Full=Cell migration-inducing gene 8 protein; AltName: Full=Fibroblast growth factor 2-interacting factor; Short=FIF; AltName: Full=Protein XAGL; FUNCTION: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. SUBUNIT: Monomer. Interacts with FGF2 and ACIN1. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. TISSUE SPECIFICITY: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. DOMAIN: Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2. PTM: Acetylation at Lys-251 impairs antiapoptotic function. SIMILARITY: Belongs to the API5 family. SEQUENCE CAUTION: Sequence=AAB86528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAB86528.1; Type=Frameshift; Positions=Several; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/api5/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZZ5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0043066 negative regulation of apoptotic process GO:2000270 negative regulation of fibroblast apoptotic process