ID:NNRE_HUMAN DESCRIPTION: RecName: Full=NAD(P)H-hydrate epimerase; EC=5.1.99.-; AltName: Full=Apolipoprotein A-I-binding protein; Short=AI-BP; AltName: Full=NAD(P)HX epimerase; AltName: Full=YjeF N-terminal domain-containing protein 1; Short=YjeF_N1; Flags: Precursor; FUNCTION: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). CATALYTIC ACTIVITY: (R)-NADHX = (S)-NADHX. COFACTOR: Binds 1 potassium ion per subunit (By similarity). SUBUNIT: Homodimer (By similarity). Interacts with APOA1 and APOA2. SUBCELLULAR LOCATION: Mitochondrion (By similarity). Secreted. Note=In sperm, secretion gradually increases during capacitation (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level). PTM: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation (By similarity). SIMILARITY: Belongs to the nnrE/AIBP family. SIMILARITY: Contains 1 YjeF N-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NCW5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006734 NADH metabolic process GO:0006739 NADP metabolic process GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway GO:0046496 nicotinamide nucleotide metabolic process GO:0051289 protein homotetramerization
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
