Human Gene APOA2 (ENST00000367990.7_8) from GENCODE V47lift37
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: APOA2_HUMAN
DESCRIPTION: RecName: Full=Apolipoprotein A-II; Short=Apo-AII; Short=ApoA-II; AltName: Full=Apolipoprotein A2; Contains: RecName: Full=Truncated apolipoprotein A-II; AltName: Full=Apolipoprotein A-II(1-76); Flags: Precursor;
FUNCTION: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. SUBUNIT: Homodimer; disulfide-linked. Also forms a disulfide- linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP and NDRG1. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Plasma; synthesized in the liver and intestine. PTM: Met-49 is oxidized to methionine sulfoxide. PTM: Phosphorylation sites are present in the extracellular medium. MASS SPECTROMETRY: Mass=17252; Method=Electrospray; Range=24-100; Note=Homodimer, without methionine sulfoxide; Source=PubMed:12576517; MASS SPECTROMETRY: Mass=17269; Method=Electrospray; Range=24-100; Note=Homodimer, with 1 methionine sulfoxide, oxidation at Met-49; Source=PubMed:12576517; MASS SPECTROMETRY: Mass=8701.2; Method=MALDI; Range=24-100; Source=PubMed:12562854; MASS SPECTROMETRY: Mass=8823.4; Method=MALDI; Range=24-100; Note=Cysteinylated ApoA-II; Source=PubMed:12562854; MASS SPECTROMETRY: Mass=17421.3; Method=MALDI; Range=24-100; Note=Homodimer; Source=PubMed:12562854; MASS SPECTROMETRY: Mass=17293.4; Method=MALDI; Range=24-100; Note=Heterodimer with truncated apolipoprotein A-II; Source=PubMed:12562854; MASS SPECTROMETRY: Mass=8578.3; Method=MALDI; Range=24-99; Source=PubMed:12562854; MASS SPECTROMETRY: Mass=17166.2; Method=MALDI; Range=24-99; Note=Homodimer; Source=PubMed:12562854; SIMILARITY: Belongs to the apolipoprotein A2 family. WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA2";
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Primer design for this transcript
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MalaCards Disease Associations
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MalaCards Gene Search: APOA2
Diseases sorted by gene-association score: apolipoprotein a-ii deficiency* (539), hypercholesterolemia, familial* (410), aapoaii amyloidosis* (350), norum disease (25), fish-eye disease (20), tangier disease (16), hypoalphalipoproteinemia (14), coronary artery disease (13), hyperalphalipoproteinemia (12), artery disease (10), hypertriglyceridemia (9), amyloidosis, familial visceral (9), familial lcat deficiency (9), leukodystrophy, hypomyelinating, 3 (9), lipoprotein glomerulopathy (8), hyperlipidemia, familial combined (7), hereditary amyloidosis (6), arcus senilis (6), hypolipoproteinemia (6), myocardial infarction (1), diabetes mellitus, noninsulin-dependent (1) * = Manually curated disease association
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Comparative Toxicogenomics Database (CTD)
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR006801 - ApoA-II
Pfam Domains: PF04711 - Apolipoprotein A-II (ApoA-II)
SCOP Domains: 47162 - Apolipoprotein
82936 - Apolipoprotein A-II
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P02652
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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KJ890686 - Synthetic construct Homo sapiens clone ccsbBroadEn_00080 APOA2 gene, encodes complete protein. JD167432 - Sequence 148456 from Patent EP1572962. M29882 - Human apolipoprotein A-II mRNA, complete cds. X00955 - Human mRNA for apolipoprotein AII precursor. BC005282 - Homo sapiens apolipoprotein A-II, mRNA (cDNA clone MGC:12334 IMAGE:3934476), complete cds. AB106565 - Homo sapiens APOA2 mRNA for apolipoprotein A-II, complete cds. JD061654 - Sequence 42678 from Patent EP1572962. JD023188 - Sequence 4212 from Patent EP1572962. JD036123 - Sequence 17147 from Patent EP1572962. JD546996 - Sequence 528020 from Patent EP1572962. JD269436 - Sequence 250460 from Patent EP1572962. JD023688 - Sequence 4712 from Patent EP1572962. AK312034 - Homo sapiens cDNA, FLJ92311, Homo sapiens apolipoprotein A-II (APOA2), mRNA. BT006786 - Homo sapiens apolipoprotein A-II mRNA, complete cds. DQ892493 - Synthetic construct clone IMAGE:100005123; FLH186817.01X; RZPDo839A1072D apolipoprotein A-II (APOA2) gene, encodes complete protein. DQ895705 - Synthetic construct Homo sapiens clone IMAGE:100010165; FLH186813.01L; RZPDo839A1062D apolipoprotein A-II (APOA2) gene, encodes complete protein. AB590164 - Synthetic construct DNA, clone: pFN21AE1405, Homo sapiens APOA2 gene for apolipoprotein A-II, without stop codon, in Flexi system. JD031806 - Sequence 12830 from Patent EP1572962. JD027115 - Sequence 8139 from Patent EP1572962. JD035046 - Sequence 16070 from Patent EP1572962. JD212080 - Sequence 193104 from Patent EP1572962. JD437982 - Sequence 419006 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: APOA2_HUMAN, B2R524, ENST00000367990.1, ENST00000367990.2, ENST00000367990.3, ENST00000367990.4, ENST00000367990.5, ENST00000367990.6, NM_001643, P02652, uc318gjh.1, uc318gjh.2 UCSC ID: ENST00000367990.7_8 RefSeq Accession: NM_001643.2
Protein: P02652
(aka APOA2_HUMAN or APA2_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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