ID:APOM_HUMAN DESCRIPTION: RecName: Full=Apolipoprotein M; Short=Apo-M; Short=ApoM; AltName: Full=Protein G3a; FUNCTION: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. SUBCELLULAR LOCATION: Secreted. Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL). TISSUE SPECIFICITY: Plasma protein. Expressed in liver and kidney. SIMILARITY: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95445
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001523 retinoid metabolic process GO:0006869 lipid transport GO:0009749 response to glucose GO:0033344 cholesterol efflux GO:0034375 high-density lipoprotein particle remodeling GO:0034380 high-density lipoprotein particle assembly GO:0034384 high-density lipoprotein particle clearance GO:0034445 negative regulation of plasma lipoprotein particle oxidation GO:0042157 lipoprotein metabolic process GO:0042632 cholesterol homeostasis GO:0043691 reverse cholesterol transport GO:0098869 cellular oxidant detoxification
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0005887 integral component of plasma membrane GO:0034361 very-low-density lipoprotein particle GO:0034362 low-density lipoprotein particle GO:0034364 high-density lipoprotein particle GO:0034365 discoidal high-density lipoprotein particle GO:0034366 spherical high-density lipoprotein particle
Descriptions from all associated GenBank mRNAs
AF161454 - Homo sapiens HSPC336 mRNA, partial cds. JD384911 - Sequence 365935 from Patent EP1572962. BC020683 - Homo sapiens apolipoprotein M, mRNA (cDNA clone MGC:22400 IMAGE:4733993), complete cds. AJ245434 - Homo sapiens mRNA for G3a protein (G3a gene, located in the class III region of the major histocompatibility complex). JD050468 - Sequence 31492 from Patent EP1572962. AF118393 - Homo sapiens apolipoprotein M mRNA, complete cds. JD067648 - Sequence 48672 from Patent EP1572962. JD117612 - Sequence 98636 from Patent EP1572962. HQ447729 - Synthetic construct Homo sapiens clone IMAGE:100071060; CCSB013087_01 apolipoprotein M (APOM) gene, encodes complete protein. KJ894289 - Synthetic construct Homo sapiens clone ccsbBroadEn_03683 APOM gene, encodes complete protein. JD444645 - Sequence 425669 from Patent EP1572962. JD236606 - Sequence 217630 from Patent EP1572962. JD550496 - Sequence 531520 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95445 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
