ID:COPD_HUMAN DESCRIPTION: RecName: Full=Coatomer subunit delta; AltName: Full=Archain; AltName: Full=Delta-coat protein; Short=Delta-COP; FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). SUBUNIT: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed. SIMILARITY: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily. SIMILARITY: Contains 1 MHD (mu homology) domain. SEQUENCE CAUTION: Sequence=CAA57072.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00928 - Adaptor complexes medium subunit family PF01217 - Clathrin adaptor complex small chain
SCOP Domains: 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor 64356 - SNARE-like
ModBase Predicted Comparative 3D Structure on P48444
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0008344 adult locomotory behavior GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0021691 cerebellar Purkinje cell layer maturation GO:0043473 pigmentation GO:0048193 Golgi vesicle transport
AF272381 - Homo sapiens clone 1370-7 MLL protein mRNA, partial cds. AK304019 - Homo sapiens cDNA FLJ51620 complete cds, highly similar to Coatomer subunit delta. LP895224 - Sequence 88 from Patent EP3253886. AK312298 - Homo sapiens cDNA, FLJ92603, Homo sapiens archain 1 (ARCN1), mRNA. BC064936 - Homo sapiens archain 1, mRNA (cDNA clone IMAGE:6157700), complete cds. BX640860 - Homo sapiens mRNA; cDNA DKFZp686M09245 (from clone DKFZp686M09245). JD106505 - Sequence 87529 from Patent EP1572962. X81197 - H.sapiens mRNA (clone pPH2) for archain. BC080638 - Homo sapiens cDNA clone IMAGE:6584541, containing frame-shift errors. BC093636 - Homo sapiens archain 1, mRNA (cDNA clone MGC:120671 IMAGE:7939481), complete cds. BC093638 - Homo sapiens archain 1, mRNA (cDNA clone MGC:120673 IMAGE:7939483), complete cds. JD273116 - Sequence 254140 from Patent EP1572962. KJ896450 - Synthetic construct Homo sapiens clone ccsbBroadEn_05844 ARCN1 gene, encodes complete protein. X81198 - H.sapiens mRNA (clone p5) for archain. JD083647 - Sequence 64671 from Patent EP1572962. JD181905 - Sequence 162929 from Patent EP1572962. JD122387 - Sequence 103411 from Patent EP1572962. JD206169 - Sequence 187193 from Patent EP1572962. JD413964 - Sequence 394988 from Patent EP1572962. JD102147 - Sequence 83171 from Patent EP1572962. JD327743 - Sequence 308767 from Patent EP1572962. JD432739 - Sequence 413763 from Patent EP1572962. JD295248 - Sequence 276272 from Patent EP1572962. JD280010 - Sequence 261034 from Patent EP1572962. JD490846 - Sequence 471870 from Patent EP1572962. JD426715 - Sequence 407739 from Patent EP1572962. JD220893 - Sequence 201917 from Patent EP1572962. JD489025 - Sequence 470049 from Patent EP1572962. JD362630 - Sequence 343654 from Patent EP1572962. JD460290 - Sequence 441314 from Patent EP1572962. JD072025 - Sequence 53049 from Patent EP1572962. JD072026 - Sequence 53050 from Patent EP1572962. JD506186 - Sequence 487210 from Patent EP1572962. JD099311 - Sequence 80335 from Patent EP1572962. JD293455 - Sequence 274479 from Patent EP1572962. JD342087 - Sequence 323111 from Patent EP1572962. JD480382 - Sequence 461406 from Patent EP1572962. JD421247 - Sequence 402271 from Patent EP1572962. JD509016 - Sequence 490040 from Patent EP1572962. JD245318 - Sequence 226342 from Patent EP1572962. JD044106 - Sequence 25130 from Patent EP1572962. JD424359 - Sequence 405383 from Patent EP1572962. JD196979 - Sequence 178003 from Patent EP1572962. JD238858 - Sequence 219882 from Patent EP1572962. JD358050 - Sequence 339074 from Patent EP1572962. JD147949 - Sequence 128973 from Patent EP1572962. JD516082 - Sequence 497106 from Patent EP1572962. JD398081 - Sequence 379105 from Patent EP1572962. JD226534 - Sequence 207558 from Patent EP1572962. JD240730 - Sequence 221754 from Patent EP1572962. JD100985 - Sequence 82009 from Patent EP1572962. JD163404 - Sequence 144428 from Patent EP1572962. JD079176 - Sequence 60200 from Patent EP1572962. JD320087 - Sequence 301111 from Patent EP1572962. JD527639 - Sequence 508663 from Patent EP1572962. JD353277 - Sequence 334301 from Patent EP1572962. JD298403 - Sequence 279427 from Patent EP1572962. JD024264 - Sequence 5288 from Patent EP1572962. JD034447 - Sequence 15471 from Patent EP1572962. JD304245 - Sequence 285269 from Patent EP1572962. JD155562 - Sequence 136586 from Patent EP1572962. JD045140 - Sequence 26164 from Patent EP1572962. JD045141 - Sequence 26165 from Patent EP1572962. JD452901 - Sequence 433925 from Patent EP1572962. JD373713 - Sequence 354737 from Patent EP1572962. JD355753 - Sequence 336777 from Patent EP1572962. JD467476 - Sequence 448500 from Patent EP1572962. JD172350 - Sequence 153374 from Patent EP1572962. JD063451 - Sequence 44475 from Patent EP1572962. JD237008 - Sequence 218032 from Patent EP1572962. JD074389 - Sequence 55413 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P48444 (Reactome details) participates in the following event(s):
R-HSA-6807872 Active ARF recruits coatomer R-HSA-6811412 Active ARF recruits coatomer to the Golgi R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
