ID:ARGI2_HUMAN DESCRIPTION: RecName: Full=Arginase-2, mitochondrial; EC=3.5.3.1; AltName: Full=Kidney-type arginase; AltName: Full=Non-hepatic arginase; AltName: Full=Type II arginase; Flags: Precursor; FUNCTION: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. CATALYTIC ACTIVITY: L-arginine + H(2)O = L-ornithine + urea. COFACTOR: Binds 2 manganese ions per subunit. PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. SUBUNIT: Homotrimer. SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas. SIMILARITY: Belongs to the arginase family. WEB RESOURCE: Name=Wikipedia; Note=Arginase entry; URL="http://en.wikipedia.org/wiki/Arginase";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78540
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004053 arginase activity GO:0016787 hydrolase activity GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0046872 metal ion binding
Biological Process: GO:0000050 urea cycle GO:0001657 ureteric bud development GO:0002250 adaptive immune response GO:0002376 immune system process GO:0002829 negative regulation of type 2 immune response GO:0006525 arginine metabolic process GO:0006809 nitric oxide biosynthetic process GO:0006941 striated muscle contraction GO:0032720 negative regulation of tumor necrosis factor production GO:0045087 innate immune response GO:0050706 regulation of interleukin-1 beta secretion GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production GO:0071644 negative regulation of chemokine (C-C motif) ligand 4 production GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production GO:1900425 negative regulation of defense response to bacterium GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1904468 negative regulation of tumor necrosis factor secretion GO:1905077 negative regulation of interleukin-17 secretion GO:1905403 negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation GO:2000666 negative regulation of interleukin-13 secretion GO:2000774 positive regulation of cellular senescence
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
