Human Gene ARGLU1 (ENST00000400198.8_9) from GENCODE V47lift37
  Description: arginine and glutamate rich 1 (from RefSeq NM_018011.4)
Gencode Transcript: ENST00000400198.8_9
Gencode Gene: ENSG00000134884.15_12
Transcript (Including UTRs)
   Position: hg19 chr13:107,194,021-107,220,485 Size: 26,465 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr13:107,196,344-107,220,267 Size: 23,924 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:107,194,021-107,220,485)mRNA (may differ from genome)Protein (273 aa)
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MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ARGL1_HUMAN
DESCRIPTION: RecName: Full=Arginine and glutamate-rich protein 1;
FUNCTION: Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.
SUBUNIT: Directly interacts with MED1.
SUBCELLULAR LOCATION: Nucleus. Note=Recruited, in an estrogen- dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.
SIMILARITY: Belongs to the UPF0430 family.
SEQUENCE CAUTION: Sequence=CAI13166.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 90.27 RPKM in Brain - Cerebellum
Total median expression: 2519.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -102.00218-0.468 Picture PostScript Text
3' UTR -520.502323-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15346 - Arginine and glutamate-rich 1

ModBase Predicted Comparative 3D Structure on Q9NWB6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0045296 cadherin binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  LF384329 - JP 2014500723-A/191832: Polycomb-Associated Non-Coding RNAs.
BC050434 - Homo sapiens arginine and glutamate rich 1, mRNA (cDNA clone MGC:54176 IMAGE:6016552), complete cds.
BC071587 - Homo sapiens arginine and glutamate rich 1, mRNA (cDNA clone MGC:87318 IMAGE:5271043), complete cds.
AK001016 - Homo sapiens cDNA FLJ10154 fis, clone HEMBA1003418.
HQ448611 - Synthetic construct Homo sapiens clone IMAGE:100072050; CCSB011614_01 hypothetical protein FLJ10154 (ARGLU1) gene, encodes complete protein.
CU690680 - Synthetic construct Homo sapiens gateway clone IMAGE:100021311 5' read FLJ10154 mRNA.
AK303575 - Homo sapiens cDNA FLJ53121 complete cds.
AK304751 - Homo sapiens cDNA FLJ54293 complete cds.
KJ902759 - Synthetic construct Homo sapiens clone ccsbBroadEn_12153 ARGLU1 gene, encodes complete protein.
CU687112 - Synthetic construct Homo sapiens gateway clone IMAGE:100022790 5' read FLJ10154 mRNA.
MA619906 - JP 2018138019-A/191832: Polycomb-Associated Non-Coding RNAs.
BC030508 - Homo sapiens arginine and glutamate rich 1, mRNA (cDNA clone IMAGE:4398434), with apparent retained intron.
JD198736 - Sequence 179760 from Patent EP1572962.
JD276715 - Sequence 257739 from Patent EP1572962.
JD357069 - Sequence 338093 from Patent EP1572962.
JD207523 - Sequence 188547 from Patent EP1572962.
CR936748 - Homo sapiens mRNA; cDNA DKFZp686O08106 (from clone DKFZp686O08106).
AK309941 - Homo sapiens cDNA, FLJ99982.
LF371064 - JP 2014500723-A/178567: Polycomb-Associated Non-Coding RNAs.
JD196413 - Sequence 177437 from Patent EP1572962.
JD023142 - Sequence 4166 from Patent EP1572962.
JD029088 - Sequence 10112 from Patent EP1572962.
MA606641 - JP 2018138019-A/178567: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ARGL1_HUMAN, B4E0Y3, ENST00000400198.1, ENST00000400198.2, ENST00000400198.3, ENST00000400198.4, ENST00000400198.5, ENST00000400198.6, ENST00000400198.7, NM_018011, Q5T257, Q6IQ34, Q9NWB6, uc319atl.1, uc319atl.2
UCSC ID: ENST00000400198.8_9
RefSeq Accession: NM_018011.4
Protein: Q9NWB6 (aka ARGL1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.