Human Gene ARHGAP1 (ENST00000311956.9_7) from GENCODE V47lift37
  Description: Rho GTPase activating protein 1 (from RefSeq NM_004308.5)
Gencode Transcript: ENST00000311956.9_7
Gencode Gene: ENSG00000175220.12_14
Transcript (Including UTRs)
   Position: hg19 chr11:46,698,630-46,722,169 Size: 23,540 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr11:46,700,587-46,717,657 Size: 17,071 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:46,698,630-46,722,169)mRNA (may differ from genome)Protein (439 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RHG01_HUMAN
DESCRIPTION: RecName: Full=Rho GTPase-activating protein 1; AltName: Full=CDC42 GTPase-activating protein; AltName: Full=GTPase-activating protein rhoOGAP; AltName: Full=Rho-related small GTPase protein activator; AltName: Full=Rho-type GTPase-activating protein 1; AltName: Full=p50-RhoGAP;
FUNCTION: GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
SUBUNIT: Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.
INTERACTION: P60953:CDC42; NbExp=2; IntAct=EBI-602762, EBI-81752; P60953-2:CDC42; NbExp=2; IntAct=EBI-602762, EBI-287394; P61586:RHOA; NbExp=2; IntAct=EBI-602762, EBI-446668;
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Contains 1 CRAL-TRIO domain.
SIMILARITY: Contains 1 Rho-GAP domain.
SEQUENCE CAUTION: Sequence=AAA16142.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ARHGAP1
Diseases sorted by gene-association score: noma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 105.04 RPKM in Bladder
Total median expression: 1944.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.90118-0.465 Picture PostScript Text
3' UTR -758.901957-0.388 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001251 - CRAL-TRIO_dom
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom

Pfam Domains:
PF00620 - RhoGAP domain
PF00650 - CRAL/TRIO domain
PF13716 - Divergent CRAL/TRIO domain

SCOP Domains:
48350 - GTPase activation domain, GAP
117023 - DNA primase DnaG, C-terminal domain
52087 - CRAL/TRIO domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1AM4 - X-ray MuPIT 1GRN - X-ray MuPIT 1OW3 - X-ray MuPIT 1RGP - X-ray MuPIT 1TX4 - X-ray MuPIT 2NGR - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q07960
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005070 SH3/SH2 adaptor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0017137 Rab GTPase binding
GO:0045296 cadherin binding

Biological Process:
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0009967 positive regulation of signal transduction
GO:0016197 endosomal transport
GO:0033572 transferrin transport
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0098706 ferric iron import across plasma membrane
GO:2001136 negative regulation of endocytic recycling

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0097443 sorting endosome


-  Descriptions from all associated GenBank mRNAs
  BC018118 - Homo sapiens Rho GTPase activating protein 1, mRNA (cDNA clone MGC:8993 IMAGE:3896574), complete cds.
U02570 - Human CDC42 GTPase-activating protein mRNA, partial cds.
JD363108 - Sequence 344132 from Patent EP1572962.
JD171540 - Sequence 152564 from Patent EP1572962.
JD061294 - Sequence 42318 from Patent EP1572962.
JD289949 - Sequence 270973 from Patent EP1572962.
JD232259 - Sequence 213283 from Patent EP1572962.
JD389600 - Sequence 370624 from Patent EP1572962.
JD191154 - Sequence 172178 from Patent EP1572962.
JD122561 - Sequence 103585 from Patent EP1572962.
JD387425 - Sequence 368449 from Patent EP1572962.
JD322122 - Sequence 303146 from Patent EP1572962.
AK298562 - Homo sapiens cDNA FLJ60782 complete cds, highly similar to Rho-GTPase-activating protein 1.
JD518498 - Sequence 499522 from Patent EP1572962.
JD346743 - Sequence 327767 from Patent EP1572962.
JD346744 - Sequence 327768 from Patent EP1572962.
JD415001 - Sequence 396025 from Patent EP1572962.
JD476808 - Sequence 457832 from Patent EP1572962.
JD460314 - Sequence 441338 from Patent EP1572962.
JD321989 - Sequence 303013 from Patent EP1572962.
JD448664 - Sequence 429688 from Patent EP1572962.
JD213069 - Sequence 194093 from Patent EP1572962.
JD542917 - Sequence 523941 from Patent EP1572962.
JD560954 - Sequence 541978 from Patent EP1572962.
JD514442 - Sequence 495466 from Patent EP1572962.
JD414486 - Sequence 395510 from Patent EP1572962.
JD524706 - Sequence 505730 from Patent EP1572962.
JD396419 - Sequence 377443 from Patent EP1572962.
JD019903 - Sequence 927 from Patent EP1572962.
JD556849 - Sequence 537873 from Patent EP1572962.
JD297545 - Sequence 278569 from Patent EP1572962.
JD551903 - Sequence 532927 from Patent EP1572962.
JD261032 - Sequence 242056 from Patent EP1572962.
JD273831 - Sequence 254855 from Patent EP1572962.
JD441973 - Sequence 422997 from Patent EP1572962.
JD204862 - Sequence 185886 from Patent EP1572962.
JD532951 - Sequence 513975 from Patent EP1572962.
JD310181 - Sequence 291205 from Patent EP1572962.
JD186009 - Sequence 167033 from Patent EP1572962.
JD157568 - Sequence 138592 from Patent EP1572962.
JD480278 - Sequence 461302 from Patent EP1572962.
JD202475 - Sequence 183499 from Patent EP1572962.
JD345040 - Sequence 326064 from Patent EP1572962.
U62794 - Human CDC42 GAP-related protein mRNA, partial cds.
JD565273 - Sequence 546297 from Patent EP1572962.
JD433369 - Sequence 414393 from Patent EP1572962.
LF209940 - JP 2014500723-A/17443: Polycomb-Associated Non-Coding RNAs.
JD385817 - Sequence 366841 from Patent EP1572962.
JD334385 - Sequence 315409 from Patent EP1572962.
JD479191 - Sequence 460215 from Patent EP1572962.
LF332926 - JP 2014500723-A/140429: Polycomb-Associated Non-Coding RNAs.
Z23024 - H.sapiens rhoGAP protein.
DQ894145 - Synthetic construct Homo sapiens clone IMAGE:100008605; FLH168115.01L; RZPDo839C0591D Rho GTPase activating protein 1 (ARHGAP1) gene, encodes complete protein.
AB528423 - Synthetic construct DNA, clone: pF1KB6626, Homo sapiens ARHGAP1 gene for Rho GTPase activating protein 1, without stop codon, in Flexi system.
CU676184 - Synthetic construct Homo sapiens gateway clone IMAGE:100019404 5' read ARHGAP1 mRNA.
LF332925 - JP 2014500723-A/140428: Polycomb-Associated Non-Coding RNAs.
AK126404 - Homo sapiens cDNA FLJ44440 fis, clone UTERU2019964, highly similar to RHO-GTPASE-ACTIVATING PROTEIN 1.
AK307296 - Homo sapiens cDNA, FLJ97244.
AK310605 - Homo sapiens cDNA, FLJ17647.
JD260734 - Sequence 241758 from Patent EP1572962.
MA445517 - JP 2018138019-A/17443: Polycomb-Associated Non-Coding RNAs.
MA568503 - JP 2018138019-A/140429: Polycomb-Associated Non-Coding RNAs.
MA568502 - JP 2018138019-A/140428: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_rhoPathway - Rho cell motility signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein Q07960 (Reactome details) participates in the following event(s):

R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis
R-HSA-194840 Rho GTPase cycle
R-HSA-194315 Signaling by Rho GTPases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: CDC42GAP, D3DQQ6, ENST00000311956.1, ENST00000311956.2, ENST00000311956.3, ENST00000311956.4, ENST00000311956.5, ENST00000311956.6, ENST00000311956.7, ENST00000311956.8, NM_004308, Q07960, RHG01_HUMAN, RHOGAP1, uc317pcv.1, uc317pcv.2
UCSC ID: ENST00000311956.9_7
RefSeq Accession: NM_004308.5
Protein: Q07960 (aka RHG01_HUMAN or RHG1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.