Human Gene ARMC5 (ENST00000268314.9_11) from GENCODE V47lift37
  Description: armadillo repeat containing 5, transcript variant 1 (from RefSeq NM_001105247.2)
Gencode Transcript: ENST00000268314.9_11
Gencode Gene: ENSG00000140691.18_17
Transcript (Including UTRs)
   Position: hg19 chr16:31,470,822-31,478,486 Size: 7,665 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr16:31,470,846-31,478,210 Size: 7,365 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:31,470,822-31,478,486)mRNA (may differ from genome)Protein (935 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ARMC5_HUMAN
DESCRIPTION: RecName: Full=Armadillo repeat-containing protein 5;
SIMILARITY: Contains 7 ARM repeats.
SIMILARITY: Contains 1 BTB (POZ) domain.
SEQUENCE CAUTION: Sequence=BAB15720.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ARMC5
Diseases sorted by gene-association score: acth-independent macronodular adrenal hyperplasia 2* (1343), cushing syndrome due to macronodular adrenal hyperplasia* (247), acth-independent macronodular adrenal hyperplasia (30), cushing's syndrome (11), adrenal cortex disease (5), adrenal gland disease (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.43 RPKM in Thyroid
Total median expression: 218.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.1024-0.212 Picture PostScript Text
3' UTR -116.50276-0.422 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR000225 - Armadillo
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q96C12
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion


-  Descriptions from all associated GenBank mRNAs
  KJ903224 - Synthetic construct Homo sapiens clone ccsbBroadEn_12618 ARMC5 gene, encodes complete protein.
AK295790 - Homo sapiens cDNA FLJ56625 complete cds, highly similar to Mus musculus armadillo repeat containing 5 (Armc5), mRNA.
AK294897 - Homo sapiens cDNA FLJ57811 complete cds, highly similar to Mus musculus armadillo repeat containing 5 (Armc5), mRNA.
AY217348 - Homo sapiens FLJ00019-like protein mRNA, complete cds.
BC014945 - Homo sapiens armadillo repeat containing 5, mRNA (cDNA clone MGC:22948 IMAGE:4860377), complete cds.
JD211133 - Sequence 192157 from Patent EP1572962.
AK024430 - Homo sapiens FLJ00019 mRNA for FLJ00019 protein.
JD389328 - Sequence 370352 from Patent EP1572962.
AK023125 - Homo sapiens cDNA FLJ13063 fis, clone NT2RP3001678.
AK297115 - Homo sapiens cDNA FLJ55719 complete cds, highly similar to Mus musculus armadillo repeat containing 5 (Armc5), mRNA.
DL491669 - Novel nucleic acids.
DL490254 - Novel nucleic acids.
JD271916 - Sequence 252940 from Patent EP1572962.
JD392794 - Sequence 373818 from Patent EP1572962.
JD153931 - Sequence 134955 from Patent EP1572962.
JD192508 - Sequence 173532 from Patent EP1572962.
JD201162 - Sequence 182186 from Patent EP1572962.
JD223353 - Sequence 204377 from Patent EP1572962.
JD536672 - Sequence 517696 from Patent EP1572962.
JD323189 - Sequence 304213 from Patent EP1572962.
JD417999 - Sequence 399023 from Patent EP1572962.
JD391145 - Sequence 372169 from Patent EP1572962.
JD387779 - Sequence 368803 from Patent EP1572962.
JD322530 - Sequence 303554 from Patent EP1572962.
JD335223 - Sequence 316247 from Patent EP1572962.
JD537789 - Sequence 518813 from Patent EP1572962.
JD540910 - Sequence 521934 from Patent EP1572962.
JD425991 - Sequence 407015 from Patent EP1572962.
JD470993 - Sequence 452017 from Patent EP1572962.
JD492806 - Sequence 473830 from Patent EP1572962.
JD233585 - Sequence 214609 from Patent EP1572962.
JD544495 - Sequence 525519 from Patent EP1572962.
JD485243 - Sequence 466267 from Patent EP1572962.
JD436401 - Sequence 417425 from Patent EP1572962.
JD343234 - Sequence 324258 from Patent EP1572962.
JD223477 - Sequence 204501 from Patent EP1572962.
JD209927 - Sequence 190951 from Patent EP1572962.
JD330606 - Sequence 311630 from Patent EP1572962.
JD040047 - Sequence 21071 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ARMC5 , ARMC5_HUMAN, ENST00000268314.1, ENST00000268314.2, ENST00000268314.3, ENST00000268314.4, ENST00000268314.5, ENST00000268314.6, ENST00000268314.7, ENST00000268314.8, NM_001105247, Q86WM9, Q96C12, Q9H7P8, Q9H925, uc317inm.1, uc317inm.2
UCSC ID: ENST00000268314.9_11
RefSeq Accession: NM_001105247.2
Protein: Q96C12 (aka ARMC5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.