Human Gene ARMC8 (ENST00000469044.6_6) from GENCODE V47lift37

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Description: armadillo repeat containing 8, transcript variant 7 (from RefSeq NM_001363941.2)
Gencode Transcript: ENST00000469044.6_6
Gencode Gene: ENSG00000114098.18_16
Transcript (Including UTRs)
Position: hg19 chr3:137,906,143-138,017,215 Size: 111,073 Total Exon Count: 22 Strand: +
Coding Region
Position: hg19 chr3:137,906,397-138,014,734 Size: 108,338 Coding Exon Count: 22

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:137,906,143-138,017,215)			mRNA (may differ from genome)		Protein (673 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ARMC8_HUMAN DESCRIPTION: RecName: Full=Armadillo repeat-containing protein 8; SIMILARITY: Contains 14 ARM repeats. SEQUENCE CAUTION: Sequence=BAA91861.1; Type=Frameshift; Positions=468; Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C012796 2-butenal D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D002737 Chloroprene D019327 Copper Sulfate D003993 Dibutyl Phthalate D005557 Formaldehyde D006861 Hydrogen Peroxide more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 22.16 RPKM in Brain - Cerebellar Hemisphere Total median expression: 344.33 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-94.80	254	-0.373	Picture	PostScript	Text
3' UTR	-653.40	2481	-0.263	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR000225 - Armadillo

Pfam Domains:
PF00514 - Armadillo/beta-catenin-like repeat

SCOP Domains:
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain

ModBase Predicted Comparative 3D Structure on Q8IUR7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0043312 neutrophil degranulation Cellular Component: GO:0005576 extracellular region GO:0035580 specific granule lumen GO:1904724 tertiary granule lumen

Descriptions from all associated GenBank mRNAs


	BC032661 - Homo sapiens armadillo repeat containing 8, mRNA (cDNA clone MGC:45133 IMAGE:5530425), complete cds. AK296757 - Homo sapiens cDNA FLJ56387 complete cds, highly similar to Mus musculus armadillo repeat containing 8 (Armc8), mRNA. AK299769 - Homo sapiens cDNA FLJ53383 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA. AF161541 - Homo sapiens HSPC056 mRNA, complete cds. AK304558 - Homo sapiens cDNA FLJ54248 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA. BC013424 - Homo sapiens armadillo repeat containing 8, mRNA (cDNA clone MGC:10058 IMAGE:3892143), complete cds. AK296837 - Homo sapiens cDNA FLJ55707 complete cds, highly similar to Mus musculus armadillo repeat containing 8 (Armc8), mRNA. AF109184 - Homo sapiens S863-2 mRNA, complete cds. AK289577 - Homo sapiens cDNA FLJ76733 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 1, mRNA. JD449842 - Sequence 430866 from Patent EP1572962. BC041699 - Homo sapiens armadillo repeat containing 8, mRNA (cDNA clone MGC:48800 IMAGE:5240423), complete cds. BC007934 - Homo sapiens cDNA clone IMAGE:4127359, ** WARNING: chimeric clone **. AK001721 - Homo sapiens cDNA FLJ10859 fis, clone NT2RP4001567, weakly similar to ARMADILLO SEGMENT POLARITY PROTEIN. CU680606 - Synthetic construct Homo sapiens gateway clone IMAGE:100017148 5' read ARMC8 mRNA. HQ448218 - Synthetic construct Homo sapiens clone IMAGE:100071619; CCSB003107_01 armadillo repeat containing 8 (ARMC8) gene, encodes complete protein. KJ893478 - Synthetic construct Homo sapiens clone ccsbBroadEn_02872 ARMC8 gene, encodes complete protein. AK315932 - Homo sapiens cDNA, FLJ78831 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA. AK299229 - Homo sapiens cDNA FLJ56232 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA. AK001882 - Homo sapiens cDNA FLJ11020 fis, clone PLACE1003625, weakly similar to ARMADILLO SEGMENT POLARITY PROTEIN. AK098500 - Homo sapiens cDNA FLJ25634 fis, clone STM04154. JD536010 - Sequence 517034 from Patent EP1572962. JD356829 - Sequence 337853 from Patent EP1572962. JD240620 - Sequence 221644 from Patent EP1572962. JD176635 - Sequence 157659 from Patent EP1572962. JD530114 - Sequence 511138 from Patent EP1572962. AL096748 - Homo sapiens mRNA; cDNA DKFZp434A043 (from clone DKFZp434A043); partial cds. JD183250 - Sequence 164274 from Patent EP1572962. JD382784 - Sequence 363808 from Patent EP1572962. AK127341 - Homo sapiens cDNA FLJ45413 fis, clone BRHIP3033481. JD358854 - Sequence 339878 from Patent EP1572962. JD413993 - Sequence 395017 from Patent EP1572962. JD087698 - Sequence 68722 from Patent EP1572962. JD245487 - Sequence 226511 from Patent EP1572962. JD289534 - Sequence 270558 from Patent EP1572962. JD183272 - Sequence 164296 from Patent EP1572962. JD184677 - Sequence 165701 from Patent EP1572962. JD242511 - Sequence 223535 from Patent EP1572962. JD299882 - Sequence 280906 from Patent EP1572962. JD111646 - Sequence 92670 from Patent EP1572962. JD169068 - Sequence 150092 from Patent EP1572962. JD254515 - Sequence 235539 from Patent EP1572962. JD154639 - Sequence 135663 from Patent EP1572962. JD248493 - Sequence 229517 from Patent EP1572962. JD214760 - Sequence 195784 from Patent EP1572962. JD549516 - Sequence 530540 from Patent EP1572962. JD207133 - Sequence 188157 from Patent EP1572962. JD196025 - Sequence 177049 from Patent EP1572962. JD380697 - Sequence 361721 from Patent EP1572962. JD319156 - Sequence 300180 from Patent EP1572962. JD383306 - Sequence 364330 from Patent EP1572962. JD040417 - Sequence 21441 from Patent EP1572962. JD165761 - Sequence 146785 from Patent EP1572962. JD333982 - Sequence 315006 from Patent EP1572962. JD316440 - Sequence 297464 from Patent EP1572962. JD502345 - Sequence 483369 from Patent EP1572962. JD557129 - Sequence 538153 from Patent EP1572962. JD303252 - Sequence 284276 from Patent EP1572962. JD059938 - Sequence 40962 from Patent EP1572962. JD184511 - Sequence 165535 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q8IUR7 (Reactome details) participates in the following event(s): R-HSA-6798749 Exocytosis of specific granule lumen proteins R-HSA-6798745 Exocytosis of tertiary granule lumen proteins R-HSA-6798695 Neutrophil degranulation R-HSA-168249 Innate Immune System R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: A8K0L2, ARMC8_HUMAN, B7Z441, B7Z453, D3DNE6, ENST00000469044.1, ENST00000469044.2, ENST00000469044.3, ENST00000469044.4, ENST00000469044.5, F5GWK4, NM_001363941, Q6PIL2, Q8IUR7, Q96D19, Q96HZ5, Q9NV02, Q9NV94, Q9Y4R9, S863-2, uc321luy.1, uc321luy.2 UCSC ID: ENST00000469044.6_6 RefSeq Accession: NM_001363941.2 Protein: Q8IUR7 (aka ARMC8_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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