ID:ARNT_HUMAN DESCRIPTION: RecName: Full=Aryl hydrocarbon receptor nuclear translocator; Short=ARNT protein; AltName: Full=Class E basic helix-loop-helix protein 2; Short=bHLHe2; AltName: Full=Dioxin receptor, nuclear translocator; AltName: Full=Hypoxia-inducible factor 1-beta; Short=HIF-1-beta; Short=HIF1-beta; FUNCTION: Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7. Heterodimer with HIF1A. INTERACTION: P35869:AHR; NbExp=5; IntAct=EBI-80809, EBI-80780; Q16665:HIF1A; NbExp=7; IntAct=EBI-80809, EBI-447269; Q8NI08:NCOA7; NbExp=2; IntAct=EBI-80809, EBI-80799; Q9Y618:NCOR2; NbExp=2; IntAct=EBI-80809, EBI-80830; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain. SIMILARITY: Contains 2 PAS (PER-ARNT-SIM) domains. SEQUENCE CAUTION: Sequence=CAD38953.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ARNTID223ch1q21.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/arnt/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P27540
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000989 transcription factor activity, transcription factor binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003713 transcription coactivator activity GO:0004874 aryl hydrocarbon receptor activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0017162 aryl hydrocarbon receptor binding GO:0035326 enhancer binding GO:0046982 protein heterodimerization activity GO:0046983 protein dimerization activity GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0001666 response to hypoxia GO:0001892 embryonic placenta development GO:0001938 positive regulation of endothelial cell proliferation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006805 xenobiotic metabolic process GO:0010575 positive regulation of vascular endothelial growth factor production GO:0030154 cell differentiation GO:0030522 intracellular receptor signaling pathway GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0033235 positive regulation of protein sumoylation GO:0042789 mRNA transcription from RNA polymerase II promoter GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0045648 positive regulation of erythrocyte differentiation GO:0045821 positive regulation of glycolytic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046886 positive regulation of hormone biosynthetic process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
