Human Gene ARPC1B (ENST00000646101.2_6) from GENCODE V47lift37
  Description: actin related protein 2/3 complex subunit 1B (from RefSeq NM_005720.4)
Gencode Transcript: ENST00000646101.2_6
Gencode Gene: ENSG00000130429.16_19
Transcript (Including UTRs)
   Position: hg19 chr7:98,972,353-98,992,439 Size: 20,087 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr7:98,983,338-98,992,112 Size: 8,775 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:98,972,353-98,992,439)mRNA (may differ from genome)Protein (372 aa)
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-  Comments and Description Text from UniProtKB
  ID: ARC1B_HUMAN
DESCRIPTION: RecName: Full=Actin-related protein 2/3 complex subunit 1B; AltName: Full=Arp2/3 complex 41 kDa subunit; AltName: Full=p41-ARC;
FUNCTION: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
SUBUNIT: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
SIMILARITY: Belongs to the WD repeat ARPC1 family.
SIMILARITY: Contains 6 WD repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.3065-0.405 Picture PostScript Text
3' UTR -88.90327-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017383 - ARPC2/3_su1
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat

SCOP Domains:
50939 - Sialidases
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
89372 - Fucose-specific lectin
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
110296 - Oligoxyloglucan reducing end-specific cellobiohydrolase
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on O15143
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0044877 macromolecular complex binding
GO:0051015 actin filament binding

Biological Process:
GO:0030833 regulation of actin filament polymerization
GO:0032355 response to estradiol
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043627 response to estrogen
GO:0048013 ephrin receptor signaling pathway

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0036284 tubulobulbar complex
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK297111 - Homo sapiens cDNA FLJ57124 complete cds, highly similar to Actin-related protein 2/3 complex subunit 1A.
BC002988 - Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa, mRNA (cDNA clone MGC:3576 IMAGE:2821335), complete cds.
JD205732 - Sequence 186756 from Patent EP1572962.
AF006084 - Homo sapiens Arp2/3 protein complex subunit p41-Arc (ARC41) mRNA, complete cds.
AK314818 - Homo sapiens cDNA, FLJ95695, Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa(ARPC1B), mRNA.
BC002562 - Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa, mRNA (cDNA clone MGC:1415 IMAGE:3138319), complete cds.
BC007555 - Homo sapiens actin related protein 2/3 complex, subunit 1B, 41kDa, mRNA (cDNA clone MGC:15479 IMAGE:2967684), complete cds.
LF211495 - JP 2014500723-A/18998: Polycomb-Associated Non-Coding RNAs.
AB463392 - Synthetic construct DNA, clone: pF1KB8200, Homo sapiens ARPC1B gene for actin related protein 2/3 complex, subunit 1B, 41kDa, without stop codon, in Flexi system.
DQ892169 - Synthetic construct clone IMAGE:100004799; FLH183646.01X; RZPDo839E12142D actin related protein 2/3 complex, subunit 1B, 41kDa (ARPC1B) gene, encodes complete protein.
DQ895363 - Synthetic construct Homo sapiens clone IMAGE:100009823; FLH183642.01L; RZPDo839E12141D actin related protein 2/3 complex, subunit 1B, 41kDa (ARPC1B) gene, encodes complete protein.
KJ892918 - Synthetic construct Homo sapiens clone ccsbBroadEn_02312 ARPC1B gene, encodes complete protein.
AY007111 - Homo sapiens clone TCCCTA00136 mRNA sequence.
LF380476 - JP 2014500723-A/187979: Polycomb-Associated Non-Coding RNAs.
LF380475 - JP 2014500723-A/187978: Polycomb-Associated Non-Coding RNAs.
LF380474 - JP 2014500723-A/187977: Polycomb-Associated Non-Coding RNAs.
JD025245 - Sequence 6269 from Patent EP1572962.
JD031185 - Sequence 12209 from Patent EP1572962.
JD023314 - Sequence 4338 from Patent EP1572962.
JD031891 - Sequence 12915 from Patent EP1572962.
JD022322 - Sequence 3346 from Patent EP1572962.
JD090934 - Sequence 71958 from Patent EP1572962.
JD508765 - Sequence 489789 from Patent EP1572962.
JD336852 - Sequence 317876 from Patent EP1572962.
JD147437 - Sequence 128461 from Patent EP1572962.
LF384071 - JP 2014500723-A/191574: Polycomb-Associated Non-Coding RNAs.
JD038334 - Sequence 19358 from Patent EP1572962.
MA619648 - JP 2018138019-A/191574: Polycomb-Associated Non-Coding RNAs.
MA447072 - JP 2018138019-A/18998: Polycomb-Associated Non-Coding RNAs.
MA616053 - JP 2018138019-A/187979: Polycomb-Associated Non-Coding RNAs.
MA616052 - JP 2018138019-A/187978: Polycomb-Associated Non-Coding RNAs.
MA616051 - JP 2018138019-A/187977: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O15143 (Reactome details) participates in the following event(s):

R-HSA-442592 WASPs or WAVEs activate the ARP2/3 complex
R-HSA-3928595 N-WASP binds ARP2/3 and G-actin
R-HSA-2029466 Attachment of preexisting mother filament and initiation of branching
R-HSA-1861595 Extension of pseudopodia by myosin-X in a PI3K dependent manner
R-HSA-2197690 Detachment of WASP/WAVE
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-195258 RHO GTPase Effectors
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-168249 Innate Immune System
R-HSA-194315 Signaling by Rho GTPases
R-HSA-422475 Axon guidance
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: ARC1B_HUMAN, ARC41, ARPC1B , ENST00000646101.1, NM_005720, O15143, Q9BU00, uc328mey.1, uc328mey.2
UCSC ID: ENST00000646101.2_6
RefSeq Accession: NM_005720.4
Protein: O15143 (aka ARC1B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.