Human Gene ARPC2 (ENST00000315717.10_4) from GENCODE V47lift37
  Description: actin related protein 2/3 complex subunit 2, transcript variant 1 (from RefSeq NM_152862.3)
Gencode Transcript: ENST00000315717.10_4
Gencode Gene: ENSG00000163466.16_7
Transcript (Including UTRs)
   Position: hg19 chr2:219,081,912-219,119,071 Size: 37,160 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr2:219,082,194-219,118,638 Size: 36,445 Coding Exon Count: 10 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:219,081,912-219,119,071)mRNA (may differ from genome)Protein (300 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 146.25 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 2662.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.1074-0.569 Picture PostScript Text
3' UTR -89.30433-0.206 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007188 - P34-arc

Pfam Domains:
PF04045 - Arp2/3 complex, 34 kD subunit p34-Arc

SCOP Domains:
48726 - Immunoglobulin
69645 - Arp2/3 complex subunits

ModBase Predicted Comparative 3D Structure on Q53R19
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding

Biological Process:
GO:0030041 actin filament polymerization
GO:0030833 regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading

Cellular Component:
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0031252 cell leading edge
GO:0036195 muscle cell projection membrane


-  Descriptions from all associated GenBank mRNAs
  U50523 - Human BRCA2 region, mRNA sequence CG037.
AK290268 - Homo sapiens cDNA FLJ76076 complete cds, highly similar to Homo sapiens actin related protein 2/3 complex, subunit 2, 34kDa (ARPC2), transcript variant 2, mRNA.
BC000590 - Homo sapiens actin related protein 2/3 complex, subunit 2, 34kDa, mRNA (cDNA clone MGC:1416 IMAGE:3346685), complete cds.
JD342607 - Sequence 323631 from Patent EP1572962.
AF006085 - Homo sapiens Arp2/3 protein complex subunit p34-Arc (ARC34) mRNA, complete cds.
HM005676 - Homo sapiens clone HTL-T-53e testis tissue sperm-binding protein Li 53e mRNA, complete cds.
JD163665 - Sequence 144689 from Patent EP1572962.
JD458309 - Sequence 439333 from Patent EP1572962.
AB463393 - Synthetic construct DNA, clone: pF1KB6382, Homo sapiens ARPC2 gene for actin related protein 2/3 complex, subunit 2, without stop codon, in Flexi system.
BT006898 - Homo sapiens actin related protein 2/3 complex, subunit 2, 34kDa mRNA, complete cds.
AF116702 - Homo sapiens PRO2446 mRNA, complete cds.
AF279893 - Homo sapiens PNAS-139 mRNA, complete cds.
JD022527 - Sequence 3551 from Patent EP1572962.
JD024517 - Sequence 5541 from Patent EP1572962.
JD035136 - Sequence 16160 from Patent EP1572962.
AK092520 - Homo sapiens cDNA FLJ35201 fis, clone PLACE6018235, highly similar to ARP2/3 COMPLEX 34 KDA SUBUNIT.
AK093625 - Homo sapiens cDNA FLJ36306 fis, clone THYMU2004843, highly similar to ARP2/3 COMPLEX 34 KDA SUBUNIT.
JD165377 - Sequence 146401 from Patent EP1572962.
JD489700 - Sequence 470724 from Patent EP1572962.
JD510675 - Sequence 491699 from Patent EP1572962.
JD326558 - Sequence 307582 from Patent EP1572962.
JD433228 - Sequence 414252 from Patent EP1572962.
JD297367 - Sequence 278391 from Patent EP1572962.
JD301890 - Sequence 282914 from Patent EP1572962.
MP015054 - Sequence 257 from Patent WO2019016252.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R457, ARPC2 , ENST00000315717.1, ENST00000315717.2, ENST00000315717.3, ENST00000315717.4, ENST00000315717.5, ENST00000315717.6, ENST00000315717.7, ENST00000315717.8, ENST00000315717.9, hCG_16304 , NM_152862, Q53R19, Q53R19_HUMAN, uc317pwf.1, uc317pwf.2
UCSC ID: ENST00000315717.10_4
RefSeq Accession: NM_152862.3
Protein: Q53R19

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.