ID:NAR4_HUMAN DESCRIPTION: RecName: Full=Ecto-ADP-ribosyltransferase 4; EC=2.4.2.31; AltName: Full=ADP-ribosyltransferase C2 and C3 toxin-like 4; Short=ARTC4; AltName: Full=Dombrock blood group carrier molecule; AltName: Full=Mono(ADP-ribosyl)transferase 4; AltName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase 4; AltName: CD_antigen=CD297; Flags: Precursor; CATALYTIC ACTIVITY: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine. CATALYTIC ACTIVITY: NADP(+) + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Expressed in spleen and T-cells. POLYMORPHISM: DO is responsible for the Dombrock blood group system. The molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)]. SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase family. WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=dombrock"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/do/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48371 - ARM repeat 56399 - ADP-ribosylation
ModBase Predicted Comparative 3D Structure on Q93070
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
