Human Gene INTS13 (ENST00000261191.12_7) from GENCODE V47lift37
  Description: integrator complex subunit 13 (from RefSeq NM_018164.3)
Gencode Transcript: ENST00000261191.12_7
Gencode Gene: ENSG00000064102.15_9
Transcript (Including UTRs)
   Position: hg19 chr12:27,058,114-27,090,914 Size: 32,801 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg19 chr12:27,058,430-27,089,736 Size: 31,307 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:27,058,114-27,090,914)mRNA (may differ from genome)Protein (706 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ASUN_HUMAN
DESCRIPTION: RecName: Full=Protein asunder homolog; AltName: Full=Cell cycle regulator Mat89Bb homolog; AltName: Full=Sarcoma antigen NY-SAR-95;
FUNCTION: Crucial regulator of the mitotic cell cycle and development.
INTERACTION: Q13951:CBFB; NbExp=2; IntAct=EBI-741429, EBI-718750;
MISCELLANEOUS: RNAi in HeLa cells results in a multinucleated phenotype.
SIMILARITY: Belongs to the asunder family.
SEQUENCE CAUTION: Sequence=AAO65180.1; Type=Frameshift; Positions=414, 445, 483, 498, 507;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.88 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 272.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -72.40197-0.368 Picture PostScript Text
3' UTR -47.40316-0.150 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019355 - Cell_cycle_regulator_Mat89Bb

Pfam Domains:
PF10221 - Cell cycle and development regulator

ModBase Predicted Comparative 3D Structure on Q9NVM9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007049 cell cycle
GO:0007052 mitotic spindle organization
GO:0007346 regulation of mitotic cell cycle
GO:0030317 flagellated sperm motility
GO:0042795 snRNA transcription from RNA polymerase II promoter
GO:0051301 cell division
GO:0051642 centrosome localization
GO:0080154 regulation of fertilization
GO:0090435 protein localization to nuclear envelope

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AL137401 - Homo sapiens mRNA; cDNA DKFZp434L032 (from clone DKFZp434L032).
AF274950 - Homo sapiens PNAS-25 mRNA, complete cds.
LF207467 - JP 2014500723-A/14970: Polycomb-Associated Non-Coding RNAs.
BC008368 - Homo sapiens chromosome 12 open reading frame 11, mRNA (cDNA clone MGC:946 IMAGE:3355282), complete cds.
AK297948 - Homo sapiens cDNA FLJ58152 complete cds.
AK001499 - Homo sapiens cDNA FLJ10637 fis, clone NT2RP2005683.
BC003081 - Homo sapiens chromosome 12 open reading frame 11, mRNA (cDNA clone MGC:943 IMAGE:2989678), complete cds.
AK001492 - Homo sapiens cDNA FLJ10630 fis, clone NT2RP2005622.
AK001222 - Homo sapiens cDNA FLJ10360 fis, clone NT2RM2001247.
LF366495 - JP 2014500723-A/173998: Polycomb-Associated Non-Coding RNAs.
AK225336 - Homo sapiens mRNA for Protein C12orf11 variant, clone: HEP10065.
JD452870 - Sequence 433894 from Patent EP1572962.
LF366496 - JP 2014500723-A/173999: Polycomb-Associated Non-Coding RNAs.
JD394844 - Sequence 375868 from Patent EP1572962.
LF366498 - JP 2014500723-A/174001: Polycomb-Associated Non-Coding RNAs.
LF366499 - JP 2014500723-A/174002: Polycomb-Associated Non-Coding RNAs.
LF366500 - JP 2014500723-A/174003: Polycomb-Associated Non-Coding RNAs.
LF366501 - JP 2014500723-A/174004: Polycomb-Associated Non-Coding RNAs.
LF366502 - JP 2014500723-A/174005: Polycomb-Associated Non-Coding RNAs.
LF366503 - JP 2014500723-A/174006: Polycomb-Associated Non-Coding RNAs.
AY211927 - Homo sapiens sarcoma antigen NY-SAR-95 mRNA, partial cds.
LF366504 - JP 2014500723-A/174007: Polycomb-Associated Non-Coding RNAs.
LF366506 - JP 2014500723-A/174009: Polycomb-Associated Non-Coding RNAs.
LF366507 - JP 2014500723-A/174010: Polycomb-Associated Non-Coding RNAs.
LF366509 - JP 2014500723-A/174012: Polycomb-Associated Non-Coding RNAs.
LF366512 - JP 2014500723-A/174015: Polycomb-Associated Non-Coding RNAs.
LF366514 - JP 2014500723-A/174017: Polycomb-Associated Non-Coding RNAs.
LF366516 - JP 2014500723-A/174019: Polycomb-Associated Non-Coding RNAs.
JD493488 - Sequence 474512 from Patent EP1572962.
JD187369 - Sequence 168393 from Patent EP1572962.
JD525476 - Sequence 506500 from Patent EP1572962.
JD162469 - Sequence 143493 from Patent EP1572962.
LF366518 - JP 2014500723-A/174021: Polycomb-Associated Non-Coding RNAs.
JD400108 - Sequence 381132 from Patent EP1572962.
MA602072 - JP 2018138019-A/173998: Polycomb-Associated Non-Coding RNAs.
MA602073 - JP 2018138019-A/173999: Polycomb-Associated Non-Coding RNAs.
MA602075 - JP 2018138019-A/174001: Polycomb-Associated Non-Coding RNAs.
MA602076 - JP 2018138019-A/174002: Polycomb-Associated Non-Coding RNAs.
MA602077 - JP 2018138019-A/174003: Polycomb-Associated Non-Coding RNAs.
MA602078 - JP 2018138019-A/174004: Polycomb-Associated Non-Coding RNAs.
MA602079 - JP 2018138019-A/174005: Polycomb-Associated Non-Coding RNAs.
MA602080 - JP 2018138019-A/174006: Polycomb-Associated Non-Coding RNAs.
MA602081 - JP 2018138019-A/174007: Polycomb-Associated Non-Coding RNAs.
MA602083 - JP 2018138019-A/174009: Polycomb-Associated Non-Coding RNAs.
MA602084 - JP 2018138019-A/174010: Polycomb-Associated Non-Coding RNAs.
MA602086 - JP 2018138019-A/174012: Polycomb-Associated Non-Coding RNAs.
MA602089 - JP 2018138019-A/174015: Polycomb-Associated Non-Coding RNAs.
MA602091 - JP 2018138019-A/174017: Polycomb-Associated Non-Coding RNAs.
MA602093 - JP 2018138019-A/174019: Polycomb-Associated Non-Coding RNAs.
MA602095 - JP 2018138019-A/174021: Polycomb-Associated Non-Coding RNAs.
MA443044 - JP 2018138019-A/14970: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NVM9 (Reactome details) participates in the following event(s):

R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ASUN , B4DNK1, C12orf11, ENST00000261191.1, ENST00000261191.10, ENST00000261191.11, ENST00000261191.2, ENST00000261191.3, ENST00000261191.4, ENST00000261191.5, ENST00000261191.6, ENST00000261191.7, ENST00000261191.8, ENST00000261191.9, GCT1, INT13_HUMAN, INTS13 , NM_018164, Q86WE2, Q96HM2, Q9BTX2, Q9NTB6, Q9NVM5, Q9NVM9, uc317gnj.1, uc317gnj.2
UCSC ID: ENST00000261191.12_7
RefSeq Accession: NM_018164.3
Protein: Q9NVM9 (aka ASUN_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.