ID:ATPG_HUMAN DESCRIPTION: RecName: Full=ATP synthase subunit gamma, mitochondrial; AltName: Full=F-ATPase gamma subunit; Flags: Precursor; FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta. SIMILARITY: Belongs to the ATPase gamma chain family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52943 - ATP synthase (F1-ATPase), gamma subunit
ModBase Predicted Comparative 3D Structure on P36542
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006119 oxidative phosphorylation GO:0006754 ATP biosynthetic process GO:0006811 ion transport GO:0015986 ATP synthesis coupled proton transport GO:0042407 cristae formation GO:0042776 mitochondrial ATP synthesis coupled proton transport GO:0099132 ATP hydrolysis coupled cation transmembrane transport
LF383674 - JP 2014500723-A/191177: Polycomb-Associated Non-Coding RNAs. BC000931 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, mRNA (cDNA clone MGC:5380 IMAGE:3445817), complete cds. BC020824 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, mRNA (cDNA clone MGC:23897 IMAGE:4733791), complete cds. AK292896 - Homo sapiens cDNA FLJ77909 complete cds, highly similar to Homo sapiens ATP synthase, H+ transporting, mitochondrial F1complex, gamma polypeptide 1 (ATP5C1), mRNA. AK296803 - Homo sapiens cDNA FLJ59921 complete cds, highly similar to ATP synthase gamma chain, mitochondrial precursor (EC 3.6.3.14). D16562 - Homo sapiens mRNA for ATP synthase gamma-subunit (L-type), complete cds. D16563 - Homo sapiens mRNA for ATP synthase gamma-subunit (H-type), complete cds. BC016812 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, mRNA (cDNA clone MGC:24478 IMAGE:4092259), complete cds. AK129907 - Homo sapiens cDNA FLJ26397 fis, clone HRT08903, highly similar to ATP synthase gamma chain, mitochondrial precursor (EC 3.6.1.34). AK294061 - Homo sapiens cDNA FLJ59861 complete cds, highly similar to ATP synthase gamma chain, mitochondrial precursor (EC 3.6.3.14). BC010380 - Homo sapiens cDNA clone IMAGE:4093178, containing frame-shift errors. BC000470 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, mRNA (cDNA clone MGC:8598 IMAGE:2961142), complete cds. BC013394 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, mRNA (cDNA clone MGC:3592 IMAGE:2961142), complete cds. BC013865 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, mRNA (cDNA clone IMAGE:3918347). CU677727 - Synthetic construct Homo sapiens gateway clone IMAGE:100023409 5' read ATP5C1 mRNA. HQ448142 - Synthetic construct Homo sapiens clone IMAGE:100071527; CCSB007522_01 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (ATP5C1) gene, encodes complete protein. KJ890734 - Synthetic construct Homo sapiens clone ccsbBroadEn_00128 ATP5C1 gene, encodes complete protein. KJ896474 - Synthetic construct Homo sapiens clone ccsbBroadEn_05868 ATP5C1 gene, encodes complete protein. CR457403 - Homo sapiens full open reading frame cDNA clone RZPDo834C0818D for gene ATP5C1, ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1; complete cds, incl. stopcodon. BC026049 - Homo sapiens, clone IMAGE:4908447, mRNA, partial cds. LF346102 - JP 2014500723-A/153605: Polycomb-Associated Non-Coding RNAs. LF346101 - JP 2014500723-A/153604: Polycomb-Associated Non-Coding RNAs. LF346100 - JP 2014500723-A/153603: Polycomb-Associated Non-Coding RNAs. LF346099 - JP 2014500723-A/153602: Polycomb-Associated Non-Coding RNAs. LF346098 - JP 2014500723-A/153601: Polycomb-Associated Non-Coding RNAs. LF346097 - JP 2014500723-A/153600: Polycomb-Associated Non-Coding RNAs. MA619251 - JP 2018138019-A/191177: Polycomb-Associated Non-Coding RNAs. MA581679 - JP 2018138019-A/153605: Polycomb-Associated Non-Coding RNAs. MA581678 - JP 2018138019-A/153604: Polycomb-Associated Non-Coding RNAs. MA581677 - JP 2018138019-A/153603: Polycomb-Associated Non-Coding RNAs. MA581676 - JP 2018138019-A/153602: Polycomb-Associated Non-Coding RNAs. MA581675 - JP 2018138019-A/153601: Polycomb-Associated Non-Coding RNAs. MA581674 - JP 2018138019-A/153600: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P36542 (Reactome details) participates in the following event(s):
R-HSA-164840 ADP and Pi bind to ATPase R-HSA-8949580 F1Fo ATP synthase dimerizes R-HSA-164834 Enzyme-bound ATP is released R-HSA-164832 ATPase synthesizes ATP R-HSA-163210 Formation of ATP by chemiosmotic coupling R-HSA-8949613 Cristae formation R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1592230 Mitochondrial biogenesis R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
