ID:ATPD_HUMAN DESCRIPTION: RecName: Full=ATP synthase subunit delta, mitochondrial; AltName: Full=F-ATPase delta subunit; Flags: Precursor; FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane. SIMILARITY: Belongs to the ATPase epsilon chain family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30049
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006119 oxidative phosphorylation GO:0006754 ATP biosynthetic process GO:0006811 ion transport GO:0015986 ATP synthesis coupled proton transport GO:0042407 cristae formation GO:0042776 mitochondrial ATP synthesis coupled proton transport GO:0046688 response to copper ion GO:0099132 ATP hydrolysis coupled cation transmembrane transport
BC002389 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit, mRNA (cDNA clone MGC:8347 IMAGE:2819749), complete cds. BC004426 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit, mRNA (cDNA clone MGC:3724 IMAGE:2819749), complete cds. BC018817 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit, mRNA (cDNA clone IMAGE:2819750). LF384661 - JP 2014500723-A/192164: Polycomb-Associated Non-Coding RNAs. JD461916 - Sequence 442940 from Patent EP1572962. JD140217 - Sequence 121241 from Patent EP1572962. AK094357 - Homo sapiens cDNA FLJ37038 fis, clone BRACE2011646, weakly similar to ATP SYNTHASE DELTA CHAIN, MITOCHONDRIAL PRECURSOR (EC 3.6.1.34). S87916 - Homo sapiens mitochondrial ATP synthase complex delta-subunit precusor mRNA, complete cds, alternatively spliced; nuclear gene for mitochondrial product. S87918 - Homo sapiens mitochondrial ATP synthase complex delta-subunit precusor mRNA, complete cds, alternatively spliced; nuclear gene for mitochondrial product. X63422 - Homo sapiens mRNA for delta-subunit of mitochondrial F1F0 ATP-synthase (clone #1). X63423 - Home sapiens mRNA for delta-subunit of mitochondrial F1F0 ATP-synthase (clone #5). BC058927 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit, mRNA (cDNA clone IMAGE:5229155), partial cds. JD467087 - Sequence 448111 from Patent EP1572962. BC050458 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit, mRNA (cDNA clone IMAGE:5770003), partial cds. LF323082 - JP 2014500723-A/130585: Polycomb-Associated Non-Coding RNAs. KJ890735 - Synthetic construct Homo sapiens clone ccsbBroadEn_00129 ATP5D gene, encodes complete protein. BC018079 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit, mRNA (cDNA clone MGC:26808 IMAGE:4798666), complete cds. CR542218 - Homo sapiens full open reading frame cDNA clone RZPDo834C0725D for gene ATP5D, ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit; complete cds, incl. stopcodon. LF323083 - JP 2014500723-A/130586: Polycomb-Associated Non-Coding RNAs. LF323085 - JP 2014500723-A/130588: Polycomb-Associated Non-Coding RNAs. LF323086 - JP 2014500723-A/130589: Polycomb-Associated Non-Coding RNAs. JD109052 - Sequence 90076 from Patent EP1572962. JD485166 - Sequence 466190 from Patent EP1572962. JD223124 - Sequence 204148 from Patent EP1572962. JD310286 - Sequence 291310 from Patent EP1572962. JD406836 - Sequence 387860 from Patent EP1572962. JD368959 - Sequence 349983 from Patent EP1572962. JD137008 - Sequence 118032 from Patent EP1572962. JD215418 - Sequence 196442 from Patent EP1572962. JD108284 - Sequence 89308 from Patent EP1572962. JD214579 - Sequence 195603 from Patent EP1572962. JD150285 - Sequence 131309 from Patent EP1572962. JD372332 - Sequence 353356 from Patent EP1572962. LF323087 - JP 2014500723-A/130590: Polycomb-Associated Non-Coding RNAs. JD381277 - Sequence 362301 from Patent EP1572962. MA620238 - JP 2018138019-A/192164: Polycomb-Associated Non-Coding RNAs. MA558659 - JP 2018138019-A/130585: Polycomb-Associated Non-Coding RNAs. MA558660 - JP 2018138019-A/130586: Polycomb-Associated Non-Coding RNAs. MA558662 - JP 2018138019-A/130588: Polycomb-Associated Non-Coding RNAs. MA558663 - JP 2018138019-A/130589: Polycomb-Associated Non-Coding RNAs. MA558664 - JP 2018138019-A/130590: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7980 - ATP biosynthesis
Reactome (by CSHL, EBI, and GO)
Protein P30049 (Reactome details) participates in the following event(s):
R-HSA-164840 ADP and Pi bind to ATPase R-HSA-8949580 F1Fo ATP synthase dimerizes R-HSA-164834 Enzyme-bound ATP is released R-HSA-164832 ATPase synthesizes ATP R-HSA-163210 Formation of ATP by chemiosmotic coupling R-HSA-8949613 Cristae formation R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1592230 Mitochondrial biogenesis R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
