ID:ATPK_HUMAN DESCRIPTION: RecName: Full=ATP synthase subunit f, mitochondrial; FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein (Potential). SIMILARITY: Belongs to the ATPase F chain family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10206 - Mitochondrial F1F0-ATP synthase, subunit f
ModBase Predicted Comparative 3D Structure on P56134
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006754 ATP biosynthetic process GO:0006811 ion transport GO:0042407 cristae formation GO:0042776 mitochondrial ATP synthesis coupled proton transport GO:0046034 ATP metabolic process GO:1902600 hydrogen ion transmembrane transport
Cellular Component: GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) GO:0005634 nucleus GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005753 mitochondrial proton-transporting ATP synthase complex GO:0016020 membrane GO:0016021 integral component of membrane GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
Descriptions from all associated GenBank mRNAs
AK295912 - Homo sapiens cDNA FLJ56092 complete cds, highly similar to Pentatricopeptide repeat protein 1. AK094388 - Homo sapiens cDNA FLJ37069 fis, clone BRACE2015287. AK123419 - Homo sapiens cDNA FLJ41425 fis, clone BRHIP2003917. AY046911 - Homo sapiens F1Fo-ATP synthase complex Fo membrane domain f subunit mRNA, complete cds; nuclear gene for mitochondrial product. AK223348 - Homo sapiens mRNA for ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f isoform 2a variant, clone: TST09133. BC003678 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2, mRNA (cDNA clone MGC:12471 IMAGE:3826469), complete cds. AF047436 - Homo sapiens F1Fo-ATPase synthase f subunit mRNA, complete cds. AF088918 - Homo sapiens F1F0-type ATPase subunit f mRNA, nuclear gene encoding mitochondrial protein, complete cds. JD048042 - Sequence 29066 from Patent EP1572962. CR542155 - Homo sapiens full open reading frame cDNA clone RZPDo834A0124D for gene ATP5J2, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2; complete cds, without stopcodon. CR456891 - Homo sapiens full open reading frame cDNA clone RZPDo834A027D for gene ATP5J2, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2; complete cds, incl. stopcodon. LF361043 - JP 2014500723-A/168546: Polycomb-Associated Non-Coding RNAs. LF365426 - JP 2014500723-A/172929: Polycomb-Associated Non-Coding RNAs. MA601003 - JP 2018138019-A/172929: Polycomb-Associated Non-Coding RNAs. MA596620 - JP 2018138019-A/168546: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7980 - ATP biosynthesis
Reactome (by CSHL, EBI, and GO)
Protein P56134 (Reactome details) participates in the following event(s):
R-HSA-164840 ADP and Pi bind to ATPase R-HSA-8949580 F1Fo ATP synthase dimerizes R-HSA-164834 Enzyme-bound ATP is released R-HSA-164832 ATPase synthesizes ATP R-HSA-163210 Formation of ATP by chemiosmotic coupling R-HSA-8949613 Cristae formation R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1592230 Mitochondrial biogenesis R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
