ID:ATPO_HUMAN DESCRIPTION: RecName: Full=ATP synthase subunit O, mitochondrial; AltName: Full=Oligomycin sensitivity conferral protein; Short=OSCP; Flags: Precursor; FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). Mitochondrion inner membrane (By similarity). SIMILARITY: Belongs to the ATPase delta chain family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00213 - ATP synthase delta (OSCP) subunit
SCOP Domains: 47928 - N-terminal domain of the delta subunit of the F1F0-ATP synthase
ModBase Predicted Comparative 3D Structure on P48047
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005215 transporter activity GO:0005515 protein binding GO:0008144 drug binding GO:0016887 ATPase activity GO:0022857 transmembrane transporter activity GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Biological Process: GO:0006754 ATP biosynthetic process GO:0006811 ion transport GO:0015986 ATP synthesis coupled proton transport GO:0042407 cristae formation GO:0042776 mitochondrial ATP synthesis coupled proton transport GO:0099132 ATP hydrolysis coupled cation transmembrane transport GO:1902600 hydrogen ion transmembrane transport
DQ656064 - Homo sapiens clone Affy2B11-13, mRNA sequence. DQ656065 - Homo sapiens clone Affy22B11-6, mRNA sequence. AF088071 - Homo sapiens full length insert cDNA clone ZD90F06. X83218 - H.sapiens mRNA for ATP synthase. AK222608 - Homo sapiens mRNA for mitochondrial ATP synthase, O subunit precursor variant, clone: CAS08612. AK093795 - Homo sapiens cDNA FLJ36476 fis, clone THYMU2017085. AK124187 - Homo sapiens cDNA FLJ42193 fis, clone THYMU2033263, moderately similar to ATP SYNTHASE OLIGOMYCIN SENSITIVITY CONFERRAL PROTEIN PRECURSOR, MITOCHONDRIAL (EC 3.6.1.34). BC021233 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit, mRNA (cDNA clone MGC:15300 IMAGE:4126036), complete cds. AK222962 - Homo sapiens mRNA for mitochondrial ATP synthase, O subunit precursor variant, clone: HRT01951. BC022865 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit, mRNA (cDNA clone MGC:23734 IMAGE:4103001), complete cds. S77356 - Homo sapiens oligomycin sensitivity conferral protein oscp-like protein mRNA, partial cds. CR456822 - Homo sapiens full open reading frame cDNA clone RZPDo834G0215D for gene ATP5O, ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein); complete cds, incl. stopcodon. AK311796 - Homo sapiens cDNA, FLJ92057, Homo sapiens ATP synthase, H+ transporting, mitochondrial F1complex, O subunit (oligomycin sensitivity conferring protein)(ATP5O), mRNA. BT019836 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein) mRNA, complete cds. JF432864 - Synthetic construct Homo sapiens clone IMAGE:100074186 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (ATP5O) gene, encodes complete protein. KJ901028 - Synthetic construct Homo sapiens clone ccsbBroadEn_10422 ATP5O gene, encodes complete protein. X83219 - H.sapiens ATP synthase gene homologue (trapped exon, HMC08D05). DQ600433 - Homo sapiens piRNA piR-38499, complete sequence. DQ656021 - Homo sapiens clone Affy08250A07, mRNA sequence. DQ656022 - Homo sapiens clone Affy08250C07, mRNA sequence.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7980 - ATP biosynthesis
Reactome (by CSHL, EBI, and GO)
Protein P48047 (Reactome details) participates in the following event(s):
R-HSA-164840 ADP and Pi bind to ATPase R-HSA-8949580 F1Fo ATP synthase dimerizes R-HSA-164834 Enzyme-bound ATP is released R-HSA-164832 ATPase synthesizes ATP R-HSA-163210 Formation of ATP by chemiosmotic coupling R-HSA-8949613 Cristae formation R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1592230 Mitochondrial biogenesis R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
