ID:B2MG_HUMAN DESCRIPTION: RecName: Full=Beta-2-microglobulin; Contains: RecName: Full=Beta-2-microglobulin form pI 5.3; Flags: Precursor; FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. INTERACTION: P06126:CD1A; NbExp=2; IntAct=EBI-714718, EBI-1036766; P29016:CD1B; NbExp=3; IntAct=EBI-714718, EBI-1033762; SUBCELLULAR LOCATION: Secreted. Note=Detected in serum and urine. PTM: Glycation of Ile-21 is observed in long-term hemodialysis patients. DISEASE: Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. DISEASE: Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. SIMILARITY: Belongs to the beta-2-microglobulin family. SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) domain. WEB RESOURCE: Name=Wikipedia; Note=Beta-2-microglobulin entry; URL="http://en.wikipedia.org/wiki/Beta-2-microglobulin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61769
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0001895 retina homeostasis GO:0001916 positive regulation of T cell mediated cytotoxicity GO:0002237 response to molecule of bacterial origin GO:0002376 immune system process GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002726 positive regulation of T cell cytokine production GO:0003254 regulation of membrane depolarization GO:0006826 iron ion transport GO:0006955 immune response GO:0010977 negative regulation of neuron projection development GO:0019731 antibacterial humoral response GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0032092 positive regulation of protein binding GO:0033077 T cell differentiation in thymus GO:0033216 ferric iron import GO:0042026 protein refolding GO:0042493 response to drug GO:0043312 neutrophil degranulation GO:0044267 cellular protein metabolic process GO:0045087 innate immune response GO:0045646 regulation of erythrocyte differentiation GO:0046686 response to cadmium ion GO:0048260 positive regulation of receptor-mediated endocytosis GO:0050690 regulation of defense response to virus by virus GO:0050776 regulation of immune response GO:0050829 defense response to Gram-negative bacterium GO:0050830 defense response to Gram-positive bacterium GO:0055072 iron ion homeostasis GO:0060333 interferon-gamma-mediated signaling pathway GO:0071222 cellular response to lipopolysaccharide GO:0071281 cellular response to iron ion GO:0071283 cellular response to iron(III) ion GO:1900121 negative regulation of receptor binding GO:1900122 positive regulation of receptor binding GO:1900390 regulation of iron ion import GO:1904434 positive regulation of ferrous iron binding GO:1904437 positive regulation of transferrin receptor binding
AF072097 - Homo sapiens beta-2 microglobulin mRNA, complete cds. AK315776 - Homo sapiens cDNA, FLJ96890, Homo sapiens beta-2-microglobulin (B2M), mRNA. AK303560 - Homo sapiens cDNA FLJ57067 complete cds, highly similar to Beta-2-microglobulin precursor. S82297 - beta 2-microglobulin {11bp deleted between nucleotides 98-99} [human, colon cancer cell line HCT, mRNA Mutant, 416 nt]. S82300 - beta 2-microglobulin {C to A point mutation at nucleotide 121} [human, colon cancer cell line HCT, mRNA Mutant, 427 nt]. S54761 - beta 2- mu =beta 2-microglobulin [human, SK-MEL-33 cells, mRNA Mutant, 433 nt]. BC032589 - Homo sapiens beta-2-microglobulin, mRNA (cDNA clone MGC:45276 IMAGE:5502428), complete cds. BC064910 - Homo sapiens beta-2-microglobulin, mRNA (cDNA clone MGC:70796 IMAGE:6055473), complete cds. X07621 - Human mutant (Daudi) beta2 - microglobulin mRNA. AY007153 - Homo sapiens clone CDABP0092 mRNA sequence. AB021288 - Homo sapiens mRNA for beta 2-microglobulin, complete cds. CR457066 - Homo sapiens full open reading frame cDNA clone RZPDo834B107D for gene B2M, beta-2-microglobulin; complete cds, incl. stopcodon. AB463439 - Synthetic construct DNA, clone: pF1KB6777, Homo sapiens B2M gene for beta-2-microglobulin, without stop codon, in Flexi system. AY187687 - Homo sapiens beta-2-microglobulin precursor, mRNA, complete cds. DQ839493 - Homo sapiens clone BFC06113 beta-2-microglobulin precursor mRNA, complete cds. DQ839494 - Homo sapiens clone BFC06014 beta-2-microglobulin precursor mRNA, complete cds. DQ884406 - Homo sapiens clone BFC06043 beta-2-microglobulin precursor mRNA, complete cds. DQ890551 - Synthetic construct clone IMAGE:100003181; FLH166536.01X; RZPDo839A0288D beta-2-microglobulin (B2M) gene, encodes complete protein. DQ893711 - Synthetic construct Homo sapiens clone IMAGE:100008171; FLH166532.01L; RZPDo839A0287D beta-2-microglobulin (B2M) gene, encodes complete protein. KJ890750 - Synthetic construct Homo sapiens clone ccsbBroadEn_00144 B2M gene, encodes complete protein. KR710896 - Synthetic construct Homo sapiens clone CCSBHm_00017962 B2M (B2M) mRNA, encodes complete protein. V00567 - Human messenger RNA fragment for the beta-2 microglobulin. AK026463 - Homo sapiens cDNA: FLJ22810 fis, clone KAIA2933, highly similar to AB021288 Homo sapiens mRNA for beta 2-microglobulin. JD218403 - Sequence 199427 from Patent EP1572962. JD095773 - Sequence 76797 from Patent EP1572962. MA868170 - JP 2018536436-A/6: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868171 - JP 2018536436-A/7: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868172 - JP 2018536436-A/8: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873659 - JP 2018536436-A/5495: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868173 - JP 2018536436-A/9: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868174 - JP 2018536436-A/10: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868175 - JP 2018536436-A/11: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868183 - JP 2018536436-A/19: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873665 - JP 2018536436-A/5501: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868184 - JP 2018536436-A/20: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868185 - JP 2018536436-A/21: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868186 - JP 2018536436-A/22: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868187 - JP 2018536436-A/23: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868188 - JP 2018536436-A/24: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868189 - JP 2018536436-A/25: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868190 - JP 2018536436-A/26: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873668 - JP 2018536436-A/5504: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868191 - JP 2018536436-A/27: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868192 - JP 2018536436-A/28: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868193 - JP 2018536436-A/29: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873671 - JP 2018536436-A/5507: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873672 - JP 2018536436-A/5508: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868211 - JP 2018536436-A/47: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868212 - JP 2018536436-A/48: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868214 - JP 2018536436-A/50: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873675 - JP 2018536436-A/5511: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868215 - JP 2018536436-A/51: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873676 - JP 2018536436-A/5512: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868216 - JP 2018536436-A/52: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868217 - JP 2018536436-A/53: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873678 - JP 2018536436-A/5514: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868218 - JP 2018536436-A/54: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868219 - JP 2018536436-A/55: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873680 - JP 2018536436-A/5516: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868220 - JP 2018536436-A/56: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873681 - JP 2018536436-A/5517: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868221 - JP 2018536436-A/57: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868222 - JP 2018536436-A/58: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868223 - JP 2018536436-A/59: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873682 - JP 2018536436-A/5518: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868224 - JP 2018536436-A/60: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868225 - JP 2018536436-A/61: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868226 - JP 2018536436-A/62: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868227 - JP 2018536436-A/63: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873683 - JP 2018536436-A/5519: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868228 - JP 2018536436-A/64: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873684 - JP 2018536436-A/5520: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873685 - JP 2018536436-A/5521: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873686 - JP 2018536436-A/5522: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868229 - JP 2018536436-A/65: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868230 - JP 2018536436-A/66: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868231 - JP 2018536436-A/67: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868232 - JP 2018536436-A/68: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868233 - JP 2018536436-A/69: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868234 - JP 2018536436-A/70: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868235 - JP 2018536436-A/71: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873689 - JP 2018536436-A/5525: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868236 - JP 2018536436-A/72: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873690 - JP 2018536436-A/5526: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868237 - JP 2018536436-A/73: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868238 - JP 2018536436-A/74: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA868239 - JP 2018536436-A/75: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA873691 - JP 2018536436-A/5527: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596071 - KR 1020180133840-A/5495: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596077 - KR 1020180133840-A/5501: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596080 - KR 1020180133840-A/5504: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596083 - KR 1020180133840-A/5507: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596084 - KR 1020180133840-A/5508: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596087 - KR 1020180133840-A/5511: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596088 - KR 1020180133840-A/5512: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596090 - KR 1020180133840-A/5514: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596092 - KR 1020180133840-A/5516: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596093 - KR 1020180133840-A/5517: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596094 - KR 1020180133840-A/5518: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596095 - KR 1020180133840-A/5519: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596096 - KR 1020180133840-A/5520: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596097 - KR 1020180133840-A/5521: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596098 - KR 1020180133840-A/5522: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596101 - KR 1020180133840-A/5525: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596102 - KR 1020180133840-A/5526: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY596103 - KR 1020180133840-A/5527: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590582 - KR 1020180133840-A/6: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590583 - KR 1020180133840-A/7: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590584 - KR 1020180133840-A/8: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590585 - KR 1020180133840-A/9: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590586 - KR 1020180133840-A/10: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590587 - KR 1020180133840-A/11: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590595 - KR 1020180133840-A/19: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590596 - KR 1020180133840-A/20: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590597 - KR 1020180133840-A/21: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590598 - KR 1020180133840-A/22: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590599 - KR 1020180133840-A/23: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590600 - KR 1020180133840-A/24: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590601 - KR 1020180133840-A/25: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590602 - KR 1020180133840-A/26: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590603 - KR 1020180133840-A/27: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590604 - KR 1020180133840-A/28: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590605 - KR 1020180133840-A/29: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590623 - KR 1020180133840-A/47: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590624 - KR 1020180133840-A/48: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590626 - KR 1020180133840-A/50: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590627 - KR 1020180133840-A/51: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590628 - KR 1020180133840-A/52: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590629 - KR 1020180133840-A/53: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590630 - KR 1020180133840-A/54: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590631 - KR 1020180133840-A/55: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590632 - KR 1020180133840-A/56: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590633 - KR 1020180133840-A/57: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590634 - KR 1020180133840-A/58: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590635 - KR 1020180133840-A/59: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590636 - KR 1020180133840-A/60: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590637 - KR 1020180133840-A/61: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590638 - KR 1020180133840-A/62: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590639 - KR 1020180133840-A/63: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590640 - KR 1020180133840-A/64: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590641 - KR 1020180133840-A/65: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590642 - KR 1020180133840-A/66: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590643 - KR 1020180133840-A/67: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590644 - KR 1020180133840-A/68: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590645 - KR 1020180133840-A/69: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590646 - KR 1020180133840-A/70: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590647 - KR 1020180133840-A/71: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590648 - KR 1020180133840-A/72: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590649 - KR 1020180133840-A/73: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590650 - KR 1020180133840-A/74: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY590651 - KR 1020180133840-A/75: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_mhcPathway - Antigen Processing and Presentation h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity h_ctlPathway - CTL mediated immune response against target cells
Reactome (by CSHL, EBI, and GO)
Protein P61769 (Reactome details) participates in the following event(s):
R-HSA-983146 Interaction of beta-2-microglobulin (B2M) chain with class I HC R-HSA-198958 KIR2DL2/3 interacting with HLA-C group 1 (Cw4) R-HSA-199587 KIR2DS1 interacting with HLA-C group 2 (Cw4) R-HSA-199062 KLRC1:KLRD1 heterodimer interacts with HLA-E R-HSA-199558 KIR2DL1 interacting with HLA-C group 2 (Cw3) R-HSA-199583 KIR2DS2 interacting with HLA-C group 1 (Cw3) R-HSA-199566 KIR3DL1 interacting with HLA Bw4 R-HSA-199576 KIR3DL2 interacting with HLA-A3 R-HSA-199579 KIR2DL4 interacting with HLA-G R-HSA-199043 LILRs interact with MHC Class I R-HSA-983426 Capturing cargo and formation of prebudding complex R-HSA-983138 Transport of MHC heterotrimer to ER exit site R-HSA-983142 Formation of peptide loading complex (PLC) R-HSA-983422 Disassembly of COPII coated vesicle R-HSA-182243 Formation of MHC I:Nef Complex R-HSA-1236943 Loading of antigen peptide onto MHC class I molecule R-HSA-6798749 Exocytosis of specific granule lumen proteins R-HSA-6798745 Exocytosis of tertiary granule lumen proteins R-HSA-198955 TCR complex interacts with peptide antigen-presenting MHC Class I R-HSA-199169 MHC Class I interacts with CD160 R-HSA-2272795 Interaction of DAP12 and KIR2DS1 R-HSA-2172126 DAP12 interacts with NKG2C R-HSA-210309 Interaction of DAP12 and KIR2DS2 R-HSA-182286 Transport of MHC I:Nef:AP-1:PACS-1 Complex R-HSA-983425 Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle R-HSA-983161 Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex R-HSA-8951499 Loading of antigenic peptides on to class I MHC R-HSA-983424 Budding of COPII coated vesicle R-HSA-182279 Formation of MHC I:Nef:AP-1:PACS-1 Complex R-HSA-2272753 Interaction of DAP12 and KIR2DS4 R-HSA-8850356 TCR binds microbial lipid-based antigen via CD1 R-HSA-8850326 TCR binds self-lipid-based antigen via CD1 R-HSA-1236954 Trimming of peptides by IRAP in endocytic vesicles R-HSA-210289 Recruitment of SYK to p-DAP12 R-HSA-2395439 Phosphorylation of DAP12 R-HSA-2395412 Phosphorylation of SYK R-HSA-2424482 p85 regulatory unit of PI3K binds p-6Y-SYK R-HSA-2395801 Phosphorylation of LAT by p-SYK R-HSA-2396594 Phosphorylation of SLP-76 by p-SYK R-HSA-2424484 Phosphorylation of BTK by p-SYK R-HSA-2424486 Phosphorylation and activation of VAV2/VAV3 by SYK R-HSA-2424480 PI3K phosphorylates PIP2 to PIP3 R-HSA-2424487 Phosphorylation of PLC-gamma by p-BTK/p-SYK R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-HSA-877300 Interferon gamma signaling R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-913531 Interferon Signaling R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1236974 ER-Phagosome pathway R-HSA-6798695 Neutrophil degranulation R-HSA-2172127 DAP12 interactions R-HSA-1280218 Adaptive Immune System R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-1236975 Antigen processing-Cross presentation R-HSA-977225 Amyloid fiber formation R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-392499 Metabolism of proteins R-HSA-2424491 DAP12 signaling R-HSA-162909 Host Interactions of HIV factors R-HSA-162906 HIV Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
