Human Gene B3GNT7 (ENST00000287590.6_4) from GENCODE V47lift37
  Description: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (from RefSeq NM_145236.3)
Gencode Transcript: ENST00000287590.6_4
Gencode Gene: ENSG00000156966.8_7
Transcript (Including UTRs)
   Position: hg19 chr2:232,260,421-232,265,875 Size: 5,455 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr2:232,260,515-232,263,636 Size: 3,122 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:232,260,421-232,265,875)mRNA (may differ from genome)Protein (401 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: B3GN7_HUMAN
DESCRIPTION: RecName: Full=UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; Short=BGnT-7; Short=Beta-1,3-Gn-T7; Short=Beta-1,3-N-acetylglucosaminyltransferase 7; Short=Beta3Gn-T7; EC=2.4.1.-;
FUNCTION: May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues.
PATHWAY: Protein modification; protein glycosylation.
SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the glycosyltransferase 31 family.
WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT7";
WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=Beta 1,3-N-acetylglucosaminyltransferase 7; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_562";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.06 RPKM in Colon - Transverse
Total median expression: 155.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.0094-0.426 Picture PostScript Text
3' UTR -921.802239-0.412 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002659 - Glyco_trans_31

Pfam Domains:
PF01762 - Galactosyltransferase
PF02434 - Fringe-like

ModBase Predicted Comparative 3D Structure on Q8NFL0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008378 galactosyltransferase activity
GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups

Biological Process:
GO:0006486 protein glycosylation
GO:0016266 O-glycan processing
GO:0018146 keratan sulfate biosynthetic process

Cellular Component:
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF205278 - JP 2014500723-A/12781: Polycomb-Associated Non-Coding RNAs.
LF205280 - JP 2014500723-A/12783: Polycomb-Associated Non-Coding RNAs.
AF502430 - Homo sapiens beta 1,3-N-acetylglucosaminyltransferase 7 mRNA, complete cds.
AK126207 - Homo sapiens cDNA FLJ44219 fis, clone THYMU3004835, highly similar to Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7), mRNA.
AB528076 - Synthetic construct DNA, clone: pF1KE0558, Homo sapiens B3GNT7 gene for UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7, without stop codon, in Flexi system.
BC140377 - Synthetic construct Homo sapiens clone IMAGE:100014436, MGC:173150 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7) mRNA, encodes complete protein.
BC148680 - Synthetic construct Homo sapiens clone IMAGE:100015708, MGC:183157 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7) mRNA, encodes complete protein.
LF318847 - JP 2014500723-A/126350: Polycomb-Associated Non-Coding RNAs.
LF318848 - JP 2014500723-A/126351: Polycomb-Associated Non-Coding RNAs.
AK000770 - Homo sapiens cDNA FLJ20763 fis, clone COL09911.
LF318849 - JP 2014500723-A/126352: Polycomb-Associated Non-Coding RNAs.
LF318851 - JP 2014500723-A/126354: Polycomb-Associated Non-Coding RNAs.
LF318854 - JP 2014500723-A/126357: Polycomb-Associated Non-Coding RNAs.
LF318855 - JP 2014500723-A/126358: Polycomb-Associated Non-Coding RNAs.
JD335778 - Sequence 316802 from Patent EP1572962.
JD392422 - Sequence 373446 from Patent EP1572962.
JD185554 - Sequence 166578 from Patent EP1572962.
JD149703 - Sequence 130727 from Patent EP1572962.
JD334689 - Sequence 315713 from Patent EP1572962.
JD370551 - Sequence 351575 from Patent EP1572962.
DQ600497 - Homo sapiens piRNA piR-38563, complete sequence.
JD554976 - Sequence 536000 from Patent EP1572962.
JD508984 - Sequence 490008 from Patent EP1572962.
JD235342 - Sequence 216366 from Patent EP1572962.
JD046234 - Sequence 27258 from Patent EP1572962.
JD403309 - Sequence 384333 from Patent EP1572962.
JD244351 - Sequence 225375 from Patent EP1572962.
MA440855 - JP 2018138019-A/12781: Polycomb-Associated Non-Coding RNAs.
MA440857 - JP 2018138019-A/12783: Polycomb-Associated Non-Coding RNAs.
MA554424 - JP 2018138019-A/126350: Polycomb-Associated Non-Coding RNAs.
MA554425 - JP 2018138019-A/126351: Polycomb-Associated Non-Coding RNAs.
MA554426 - JP 2018138019-A/126352: Polycomb-Associated Non-Coding RNAs.
MA554428 - JP 2018138019-A/126354: Polycomb-Associated Non-Coding RNAs.
MA554431 - JP 2018138019-A/126357: Polycomb-Associated Non-Coding RNAs.
MA554432 - JP 2018138019-A/126358: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8NFL0 (Reactome details) participates in the following event(s):

R-HSA-914010 Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein
R-HSA-2025724 B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-5173105 O-linked glycosylation
R-HSA-1638074 Keratan sulfate/keratin metabolism
R-HSA-597592 Post-translational protein modification
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-392499 Metabolism of proteins
R-HSA-71387 Metabolism of carbohydrates
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B3GN7_HUMAN, B3GNT7 , B3KWY4, B7WNP0, ENST00000287590.1, ENST00000287590.2, ENST00000287590.3, ENST00000287590.4, ENST00000287590.5, NM_145236, Q8NFL0, uc317knd.1, uc317knd.2
UCSC ID: ENST00000287590.6_4
RefSeq Accession: NM_145236.3
Protein: Q8NFL0 (aka B3GN7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.