ID:BAI1_HUMAN DESCRIPTION: RecName: Full=Brain-specific angiogenesis inhibitor 1; Flags: Precursor; FUNCTION: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain. SUBUNIT: Interacts with ELMO1 and DOCK1. When bound to ELMO1 and DOCK1, it may act as a module to promote the engulfment (By similarity). Interacts with MAGI1, MAGI3, BAIAP2 and PHYHIP. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Likely to be concentrated at cell-cell adhesion sites. TISSUE SPECIFICITY: Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes. INDUCTION: By p53/TP53. DOMAIN: The TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGF. PTM: The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. SIMILARITY: Contains 1 GPS domain. SIMILARITY: Contains 5 TSP type-1 domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like 82895 - TSP-1 type 1 repeat 111418 - Hormone receptor domain
ModBase Predicted Comparative 3D Structure on O14514
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0006909 phagocytosis GO:0006910 phagocytosis, recognition GO:0006911 phagocytosis, engulfment GO:0007155 cell adhesion GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0007186 G-protein coupled receptor signaling pathway GO:0007399 nervous system development GO:0007409 axonogenesis GO:0007422 peripheral nervous system development GO:0007517 muscle organ development GO:0008285 negative regulation of cell proliferation GO:0010596 negative regulation of endothelial cell migration GO:0016525 negative regulation of angiogenesis GO:0031397 negative regulation of protein ubiquitination GO:0042177 negative regulation of protein catabolic process GO:0043277 apoptotic cell clearance GO:0043652 engulfment of apoptotic cell GO:0045087 innate immune response GO:0048167 regulation of synaptic plasticity GO:0050829 defense response to Gram-negative bacterium GO:0051965 positive regulation of synapse assembly GO:1901741 positive regulation of myoblast fusion GO:1903428 positive regulation of reactive oxygen species biosynthetic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
