Human Gene ADGRB2 (ENST00000373655.6_10) from GENCODE V47lift37
  Description: adhesion G protein-coupled receptor B2, transcript variant 1 (from RefSeq NM_001294335.2)
Gencode Transcript: ENST00000373655.6_10
Gencode Gene: ENSG00000121753.13_19
Transcript (Including UTRs)
   Position: hg19 chr1:32,192,718-32,229,636 Size: 36,919 Total Exon Count: 33 Strand: -
Coding Region
   Position: hg19 chr1:32,193,021-32,222,822 Size: 29,802 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:32,192,718-32,229,636)mRNA (may differ from genome)Protein (1584 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BAI2_HUMAN
DESCRIPTION: RecName: Full=Brain-specific angiogenesis inhibitor 2; Flags: Precursor;
FUNCTION: Might be involved in angiogenesis inhibition.
SUBUNIT: Interacts with GABPB2 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.
SIMILARITY: Contains 4 TSP type-1 domains.
SEQUENCE CAUTION: Sequence=BAA25362.1; Type=Erroneous initiation; Sequence=CAI16890.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 57.79 RPKM in Brain - Cortex
Total median expression: 417.76 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -132.40342-0.387 Picture PostScript Text
3' UTR -132.00303-0.436 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022624 - DUF3497
IPR017981 - GPCR_2-like
IPR008077 - GPCR_2_brain-spec_angio_inhib
IPR001879 - GPCR_2_extracellular_dom
IPR000832 - GPCR_2_secretin-like
IPR000203 - GPS_dom
IPR000884 - Thrombospondin_1_rpt

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF00090 - Thrombospondin type 1 domain
PF01825 - GPCR proteolysis site, GPS, motif
PF16489 - GPCR-Autoproteolysis INducing (GAIN) domain
PF19188 - Adhesion GPCR B N-terminal region

SCOP Domains:
49265 - Fibronectin type III
81321 - Family A G protein-coupled receptor-like
82895 - TSP-1 type 1 repeat
111418 - Hormone receptor domain

ModBase Predicted Comparative 3D Structure on O60241
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007422 peripheral nervous system development
GO:0016525 negative regulation of angiogenesis
GO:0033173 calcineurin-NFAT signaling cascade
GO:0051965 positive regulation of synapse assembly

Cellular Component:
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC053513 - Homo sapiens cDNA clone IMAGE:6598864, **** WARNING: chimeric clone ****.
BC014780 - Homo sapiens brain-specific angiogenesis inhibitor 2, mRNA (cDNA clone IMAGE:4154610), with apparent retained intron.
BC009035 - Homo sapiens, Similar to brain-specific angiogenesis inhibitor 2, clone IMAGE:4155920, mRNA, partial cds.
AK123392 - Homo sapiens cDNA FLJ41398 fis, clone BRCOC2019896, highly similar to Homo sapiens brain-specific angiogenesis inhibitor 2 (BAI2).
AB005298 - Homo sapiens BAI 2 mRNA, complete cds.
JD162918 - Sequence 143942 from Patent EP1572962.
JD468107 - Sequence 449131 from Patent EP1572962.
BC136533 - Homo sapiens brain-specific angiogenesis inhibitor 2, mRNA (cDNA clone MGC:168146 IMAGE:9020523), complete cds.
AK294361 - Homo sapiens cDNA FLJ55343 complete cds, highly similar to Brain-specific angiogenesis inhibitor 2 precursor.
JD139034 - Sequence 120058 from Patent EP1572962.
AK296502 - Homo sapiens cDNA FLJ53350 complete cds, highly similar to Brain-specific angiogenesis inhibitor 2 precursor.
JD442632 - Sequence 423656 from Patent EP1572962.
JD296825 - Sequence 277849 from Patent EP1572962.
AB384403 - Synthetic construct DNA, clone: pF1KSDB1489, Homo sapiens BAI2 gene for brain-specific angiogenesis inhibitor 2 precursor, complete cds, without stop codon, in Flexi system.
AK294999 - Homo sapiens cDNA FLJ52539 complete cds, highly similar to Brain-specific angiogenesis inhibitor 2 precursor.
AK307805 - Homo sapiens cDNA, FLJ97753.
JD490908 - Sequence 471932 from Patent EP1572962.
JD160214 - Sequence 141238 from Patent EP1572962.
JD158498 - Sequence 139522 from Patent EP1572962.
JD271036 - Sequence 252060 from Patent EP1572962.
JD389946 - Sequence 370970 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ADGRB2 , AGRB2_HUMAN, B9EGK9, BAI2, ENST00000373655.1, ENST00000373655.2, ENST00000373655.3, ENST00000373655.4, ENST00000373655.5, NM_001294335, O60241, Q5T6K0, Q8NGW8, Q96GZ9, uc318kyi.1, uc318kyi.2
UCSC ID: ENST00000373655.6_10
RefSeq Accession: NM_001294335.2
Protein: O60241 (aka BAI2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.