ID:BANK1_HUMAN DESCRIPTION: RecName: Full=B-cell scaffold protein with ankyrin repeats; FUNCTION: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. SUBUNIT: Interacts with LYN, ITPR1 and ITPR2. TISSUE SPECIFICITY: Expressed in B-cell but not T-cell or myeloid cell lines. Highest expression in CD19(+) B-cells, with very low expression in other cell populations. PTM: Phosphorylated on tyrosines upon BCR activation. DISEASE: Genetic variations in BANK1 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. SIMILARITY: Contains 2 ANK repeats. SIMILARITY: Contains 1 DBB domain. SEQUENCE CAUTION: Sequence=BAA91337.1; Type=Frameshift; Positions=571, 681;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NDB2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005102 receptor binding GO:1990782 protein tyrosine kinase binding
Biological Process: GO:0042113 B cell activation GO:0043410 positive regulation of MAPK cascade GO:0045947 negative regulation of translational initiation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050869 negative regulation of B cell activation GO:0051898 negative regulation of protein kinase B signaling GO:1900165 negative regulation of interleukin-6 secretion
Descriptions from all associated GenBank mRNAs
AK091523 - Homo sapiens cDNA FLJ34204 fis, clone FCBBF3019867. AX747038 - Sequence 563 from Patent EP1308459. BC032241 - Homo sapiens B-cell scaffold protein with ankyrin repeats 1, mRNA (cDNA clone MGC:39917 IMAGE:5214147), complete cds. AK292133 - Homo sapiens cDNA FLJ77584 complete cds, highly similar to Homo sapiens B-cell scaffold protein with ankyrin repeats 1 (BANK1), mRNA. AL834291 - Homo sapiens mRNA; cDNA DKFZp667N1611 (from clone DKFZp667N1611). EU051376 - Homo sapiens B-cell scaffold protein with ankyrin repeats 1 delta 2 transcript variant (BANK1) mRNA, complete cds. AB587395 - Synthetic construct DNA, clone: pF1KB5713, Homo sapiens BANK1 gene for B-cell scaffold protein with ankyrin repeats 1, without stop codon, in Flexi system. AK000713 - Homo sapiens cDNA FLJ20706 fis, clone KAIA1273. CU689310 - Synthetic construct Homo sapiens gateway clone IMAGE:100017802 5' read BANK1 mRNA. DQ894247 - Synthetic construct Homo sapiens clone IMAGE:100008707; FLH169010.01L; RZPDo839F0793D B-cell scaffold protein with ankyrin repeats 1 (BANK1) gene, encodes complete protein. DQ891066 - Synthetic construct clone IMAGE:100003696; FLH169014.01X; RZPDo839F0794D B-cell scaffold protein with ankyrin repeats 1 (BANK1) gene, encodes complete protein. KJ899060 - Synthetic construct Homo sapiens clone ccsbBroadEn_08454 BANK1 gene, encodes complete protein. KR710822 - Synthetic construct Homo sapiens clone CCSBHm_00017416 BANK1 (BANK1) mRNA, encodes complete protein. KR710823 - Synthetic construct Homo sapiens clone CCSBHm_00017417 BANK1 (BANK1) mRNA, encodes complete protein. AB063170 - Homo sapiens mRNA for BANK, complete cds. AK301936 - Homo sapiens cDNA FLJ60038 complete cds, highly similar to Homo sapiens B-cell scaffold protein with ankyrin repeats 1 (BANK1), mRNA. JD218558 - Sequence 199582 from Patent EP1572962. JD150948 - Sequence 131972 from Patent EP1572962. JD448965 - Sequence 429989 from Patent EP1572962. AK093024 - Homo sapiens cDNA FLJ35705 fis, clone SPLEN2020223. JD522176 - Sequence 503200 from Patent EP1572962. JD193580 - Sequence 174604 from Patent EP1572962. JD419901 - Sequence 400925 from Patent EP1572962. JD071551 - Sequence 52575 from Patent EP1572962. JD299368 - Sequence 280392 from Patent EP1572962. JD553268 - Sequence 534292 from Patent EP1572962. JD486147 - Sequence 467171 from Patent EP1572962. JD412252 - Sequence 393276 from Patent EP1572962. JD062967 - Sequence 43991 from Patent EP1572962. JD554256 - Sequence 535280 from Patent EP1572962. JD551057 - Sequence 532081 from Patent EP1572962. JD092484 - Sequence 73508 from Patent EP1572962.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
