ID:PGCB_HUMAN DESCRIPTION: RecName: Full=Brevican core protein; AltName: Full=Brain-enriched hyaluronan-binding protein; Short=BEHAB; AltName: Full=Chondroitin sulfate proteoglycan 7; Flags: Precursor; FUNCTION: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. SUBUNIT: Interacts with TNR (By similarity). SUBCELLULAR LOCATION: Isoform 1: Secreted, extracellular space, extracellular matrix. SUBCELLULAR LOCATION: Isoform 2: Membrane; Lipid-anchor, GPI- anchor. DEVELOPMENTAL STAGE: Isoform 1 is highly expressed from birth through 8 years of age and is down-regulated by 20 years of age to low levels that are maintained in the normal adult cortex. Isoform 2 is expressed at uniformly low levels throughout development. PTM: Contains mostly chondroitin sulfate (By similarity). O- glycosylated with a core 1 or possibly core 8 glycan. SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. SIMILARITY: Contains 1 C-type lectin domain. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SIMILARITY: Contains 2 Link domains. SIMILARITY: Contains 1 Sushi (CCP/SCR) domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Brevican; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_212";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96GW7
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001501 skeletal system development GO:0007155 cell adhesion GO:0007417 central nervous system development GO:0021766 hippocampus development GO:0030198 extracellular matrix organization GO:0030206 chondroitin sulfate biosynthetic process GO:0030207 chondroitin sulfate catabolic process GO:0030208 dermatan sulfate biosynthetic process
LF211903 - JP 2014500723-A/19406: Polycomb-Associated Non-Coding RNAs. LF206160 - JP 2014500723-A/13663: Polycomb-Associated Non-Coding RNAs. JA482196 - Sequence 179 from Patent WO2011072091. JE980488 - Sequence 179 from Patent EP2862929. AY358372 - Homo sapiens clone DNA98565 Brevican Core Pro (UNQ2525) mRNA, complete cds. JA482195 - Sequence 178 from Patent WO2011072091. JE980487 - Sequence 178 from Patent EP2862929. LF385406 - JP 2014500723-A/192909: Polycomb-Associated Non-Coding RNAs. AK289759 - Homo sapiens cDNA FLJ76746 complete cds, highly similar to Homo sapiens brevican (BCAN), transcript variant 1, mRNA. BC029348 - Homo sapiens cDNA clone IMAGE:4180213, containing frame-shift errors. AY007241 - Homo sapiens hyaluronan binding protein (HABP2) mRNA, partial cds. BC022938 - Homo sapiens brevican, mRNA (cDNA clone MGC:24965 IMAGE:4932894), complete cds. BC035457 - Homo sapiens brevican, mRNA (cDNA clone IMAGE:4156034). BC027971 - Homo sapiens brevican, mRNA (cDNA clone MGC:34716 IMAGE:5309663), complete cds. BC009117 - Homo sapiens brevican, mRNA (cDNA clone MGC:18150 IMAGE:4154474), complete cds. JD520361 - Sequence 501385 from Patent EP1572962. JD458421 - Sequence 439445 from Patent EP1572962. BC010571 - Homo sapiens brevican, mRNA (cDNA clone IMAGE:4215184). JD204053 - Sequence 185077 from Patent EP1572962. AF229053 - Homo sapiens chondroitin sulfate proteoglycan BEHAB/brevican mRNA, GPI isoform, complete cds. AF228710 - Homo sapiens chondroitin sulfate proteoglycan BEHAB/brevican mRNA, soluble isoform, complete cds. JD070890 - Sequence 51914 from Patent EP1572962. CU692756 - Synthetic construct Homo sapiens gateway clone IMAGE:100020528 5' read BCAN mRNA. KJ899412 - Synthetic construct Homo sapiens clone ccsbBroadEn_08806 BCAN gene, encodes complete protein. KJ899413 - Synthetic construct Homo sapiens clone ccsbBroadEn_08807 BCAN gene, encodes complete protein. AB527863 - Synthetic construct DNA, clone: pF1KB8564, Homo sapiens BCAN gene for brevican, without stop codon, in Flexi system. AB209570 - Homo sapiens mRNA for brevican isoform 1 variant protein. BC029313 - Homo sapiens brevican, mRNA (cDNA clone IMAGE:4157828). BC023209 - Homo sapiens brevican, mRNA (cDNA clone IMAGE:4940883). LF352062 - JP 2014500723-A/159565: Polycomb-Associated Non-Coding RNAs. LF352061 - JP 2014500723-A/159564: Polycomb-Associated Non-Coding RNAs. BC013234 - Homo sapiens brevican, mRNA (cDNA clone IMAGE:4154690). AL137504 - Homo sapiens mRNA; cDNA DKFZp761L191 (from clone DKFZp761L191); partial cds. AK126588 - Homo sapiens cDNA FLJ44625 fis, clone BRACE2017438, highly similar to Homo sapiens chondroitin sulfate proteoglycan BEHAB/brevican (BCAN). JD218981 - Sequence 200005 from Patent EP1572962. JD221396 - Sequence 202420 from Patent EP1572962. JD383410 - Sequence 364434 from Patent EP1572962. JD332592 - Sequence 313616 from Patent EP1572962. JD417913 - Sequence 398937 from Patent EP1572962. JD061176 - Sequence 42200 from Patent EP1572962. JD456733 - Sequence 437757 from Patent EP1572962. JD288791 - Sequence 269815 from Patent EP1572962. JD356065 - Sequence 337089 from Patent EP1572962. MA620983 - JP 2018138019-A/192909: Polycomb-Associated Non-Coding RNAs. MA587639 - JP 2018138019-A/159565: Polycomb-Associated Non-Coding RNAs. MA587638 - JP 2018138019-A/159564: Polycomb-Associated Non-Coding RNAs. MA447480 - JP 2018138019-A/19406: Polycomb-Associated Non-Coding RNAs. MA441737 - JP 2018138019-A/13663: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96GW7 (Reactome details) participates in the following event(s):
R-HSA-2018659 Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 R-HSA-1889955 B3GATs transfer GlcA to tetrasaccharide linker R-HSA-1889978 B3GALT6 transfers Gal to the tetrasaccharide linker R-HSA-1889981 B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker R-HSA-1971487 CHPF,CHSY1,CHSY3 transfer GalNAc to chondroitin R-HSA-1971491 CHPF,CHPF2,CHSY1,CHSY3 transfer GlcA to chondroitin R-HSA-1878002 XYLTs transfer Xyl to core protein R-HSA-3788075 Brevican degradation by ADAMTS4, ADAMTS5 R-HSA-3791149 Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 R-HSA-1971483 Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 R-HSA-2018682 CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains R-HSA-1971482 The addition of GalNAc to the terminal glucuronate residue forms chondroitin R-HSA-2022061 Dermatan sulfate can be further sulfated on position 2 of iduronate R-HSA-2424246 Tenascins C, R, (X, N) bind lecticans R-HSA-2022052 Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) R-HSA-2022063 CHST14 transfers SO4(2-) to GalNAc in dermatan or DS R-HSA-2022870 Chondroitin sulfate biosynthesis R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-3595177 Defective CHSY1 causes TPBS R-HSA-1474228 Degradation of the extracellular matrix R-HSA-3595172 Defective CHST3 causes SEDCJD R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-2024101 CS/DS degradation R-HSA-2022923 Dermatan sulfate biosynthesis R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism R-HSA-3000178 ECM proteoglycans R-HSA-1474244 Extracellular matrix organization R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type R-HSA-1630316 Glycosaminoglycan metabolism R-HSA-3781865 Diseases of glycosylation R-HSA-71387 Metabolism of carbohydrates R-HSA-1643685 Disease R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
