ID:BC11B_HUMAN DESCRIPTION: RecName: Full=B-cell lymphoma/leukemia 11B; Short=BCL-11B; AltName: Full=B-cell CLL/lymphoma 11B; AltName: Full=COUP-TF-interacting protein 2; AltName: Full=Radiation-induced tumor suppressor gene 1 protein; Short=hRit1; FUNCTION: Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). SUBUNIT: Interacts with TFCOUP1, SIRT1, ARP1 and EAR2 (By similarity). SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma. SIMILARITY: Contains 6 C2H2-type zinc fingers. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BCL11BID392.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9C0K0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding
Biological Process: GO:0003334 keratinocyte development GO:0003382 epithelial cell morphogenesis GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007165 signal transduction GO:0007409 axonogenesis GO:0008285 negative regulation of cell proliferation GO:0009791 post-embryonic development GO:0010468 regulation of gene expression GO:0010837 regulation of keratinocyte proliferation GO:0019216 regulation of lipid metabolic process GO:0021773 striatal medium spiny neuron differentiation GO:0021902 commitment of neuronal cell to specific neuron type in forebrain GO:0021953 central nervous system neuron differentiation GO:0022008 neurogenesis GO:0031077 post-embryonic camera-type eye development GO:0033077 T cell differentiation in thymus GO:0033153 T cell receptor V(D)J recombination GO:0035701 hematopoietic stem cell migration GO:0042475 odontogenesis of dentin-containing tooth GO:0043066 negative regulation of apoptotic process GO:0043368 positive T cell selection GO:0043588 skin development GO:0045664 regulation of neuron differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046632 alpha-beta T cell differentiation GO:0048538 thymus development GO:0071678 olfactory bulb axon guidance GO:0097535 lymphoid lineage cell migration into thymus
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
