ID:B2LA1_HUMAN DESCRIPTION: RecName: Full=Bcl-2-related protein A1; AltName: Full=Bcl-2-like protein 5; Short=Bcl2-L-5; AltName: Full=Hemopoietic-specific early response protein; AltName: Full=Protein BFL-1; AltName: Full=Protein GRS; FUNCTION: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). SUBUNIT: Interacts directly with BAK1, BID, BMF and BBC3 (By similarity). Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. INDUCTION: By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors. SIMILARITY: Belongs to the Bcl-2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16548
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0015267 channel activity GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0001836 release of cytochrome c from mitochondria GO:0006915 apoptotic process GO:0008053 mitochondrial fusion GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0055085 transmembrane transport GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
