ID:B2CL1_HUMAN DESCRIPTION: RecName: Full=Bcl-2-like protein 1; Short=Bcl2-L-1; AltName: Full=Apoptosis regulator Bcl-X; FUNCTION: Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. FUNCTION: Isoform Bcl-X(S) promotes apoptosis. SUBUNIT: Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with DMN1L; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters (By similarity). Interacts with BAD and BBC3. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Interacts (isoform Bcl-X(L)) with BAX (isoform Sigma). Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. INTERACTION: Q92934:BAD; NbExp=6; IntAct=EBI-287195, EBI-700771; Q61337:Bad (xeno); NbExp=2; IntAct=EBI-287195, EBI-400328; Q16611:BAK1; NbExp=8; IntAct=EBI-287195, EBI-519866; Q07812:BAX; NbExp=13; IntAct=EBI-287195, EBI-516580; Q9BXH1:BBC3; NbExp=7; IntAct=EBI-287195, EBI-519884; Q99ML1:Bbc3 (xeno); NbExp=3; IntAct=EBI-287195, EBI-727801; O43521:BCL2L11; NbExp=8; IntAct=EBI-287195, EBI-526406; O43521-1:BCL2L11; NbExp=2; IntAct=EBI-287195, EBI-526416; Q14457:BECN1; NbExp=4; IntAct=EBI-287195, EBI-949378; P55957:BID; NbExp=6; IntAct=EBI-287195, EBI-519672; Q13323:BIK; NbExp=3; IntAct=EBI-287195, EBI-700794; P30429:ced-4 (xeno); NbExp=3; IntAct=EBI-78035, EBI-494118; P10909-4:CLU; NbExp=6; IntAct=EBI-287195, EBI-4322678; O00198:HRK; NbExp=2; IntAct=EBI-287195, EBI-701322; Q9C000:NLRP1; NbExp=9; IntAct=EBI-78035, EBI-1220518; O15304:SIVA1; NbExp=2; IntAct=EBI-287195, EBI-520756; O15304-1:SIVA1; NbExp=5; IntAct=EBI-287195, EBI-520766; Q9H2V7:SPNS1; NbExp=3; IntAct=EBI-78035, EBI-1386527; P04637:TP53; NbExp=18; IntAct=EBI-287195, EBI-366083; P02340:Tp53 (xeno); NbExp=3; IntAct=EBI-287195, EBI-474016; SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton, centrosome. Note=Mitochondrial membranes and perinuclear envelope (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. TISSUE SPECIFICITY: Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. DOMAIN: The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. PTM: Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity. PTM: Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis. SIMILARITY: Belongs to the Bcl-2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q07817
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001541 ovarian follicle development GO:0001701 in utero embryonic development GO:0001836 release of cytochrome c from mitochondria GO:0006897 endocytosis GO:0006915 apoptotic process GO:0007093 mitotic cell cycle checkpoint GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0008283 cell proliferation GO:0008284 positive regulation of cell proliferation GO:0008584 male gonad development GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008637 apoptotic mitochondrial changes GO:0009314 response to radiation GO:0009566 fertilization GO:0009615 response to virus GO:0010507 negative regulation of autophagy GO:0019050 suppression by virus of host apoptotic process GO:0019221 cytokine-mediated signaling pathway GO:0032465 regulation of cytokinesis GO:0034097 response to cytokine GO:0040007 growth GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0046898 response to cycloheximide GO:0046902 regulation of mitochondrial membrane permeability GO:0051402 neuron apoptotic process GO:0051881 regulation of mitochondrial membrane potential GO:0060154 cellular process regulating host cell cycle in response to virus GO:0070584 mitochondrion morphogenesis GO:0071230 cellular response to amino acid stimulus GO:0071312 cellular response to alkaloid GO:0071480 cellular response to gamma radiation GO:0071839 apoptotic process in bone marrow GO:0090201 negative regulation of release of cytochrome c from mitochondria GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097284 hepatocyte apoptotic process GO:1900118 negative regulation of execution phase of apoptosis GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1903077 negative regulation of protein localization to plasma membrane GO:2000811 negative regulation of anoikis GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001243 negative regulation of intrinsic apoptotic signaling pathway GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
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Common Gene Haplotype Alleles 
