ID:BCL3_HUMAN DESCRIPTION: RecName: Full=B-cell lymphoma 3 protein; Short=BCL-3; AltName: Full=Proto-oncogene BCL3; FUNCTION: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). SUBUNIT: Component of a complex consisting of the NF-kappa-B p52- p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD (By similarity). INTERACTION: O95999:BCL10; NbExp=3; IntAct=EBI-958997, EBI-958922; P56545:CTBP2; NbExp=2; IntAct=EBI-958997, EBI-741533; SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation (By similarity). PTM: Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity). PTM: Activated by phosphorylation. DISEASE: Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions. SIMILARITY: Contains 7 ANK repeats. CAUTION: It is uncertain whether Met-1 or Met-9 is the initiator. SEQUENCE CAUTION: Sequence=AAA51815.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAA51816.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH64993.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20749
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0030674 protein binding, bridging
Biological Process: GO:0000060 protein import into nucleus, translocation GO:0002268 follicular dendritic cell differentiation GO:0002315 marginal zone B cell differentiation GO:0002455 humoral immune response mediated by circulating immunoglobulin GO:0002467 germinal center formation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006974 cellular response to DNA damage stimulus GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0009615 response to virus GO:0010225 response to UV-C GO:0019730 antimicrobial humoral response GO:0030198 extracellular matrix organization GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0032729 positive regulation of interferon-gamma production GO:0042088 T-helper 1 type immune response GO:0042536 negative regulation of tumor necrosis factor biosynthetic process GO:0042742 defense response to bacterium GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042832 defense response to protozoan GO:0042981 regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0045064 T-helper 2 cell differentiation GO:0045082 positive regulation of interleukin-10 biosynthetic process GO:0045415 negative regulation of interleukin-8 biosynthetic process GO:0045727 positive regulation of translation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046426 negative regulation of JAK-STAT cascade GO:0048536 spleen development GO:0051101 regulation of DNA binding GO:0051457 maintenance of protein location in nucleus GO:1901222 regulation of NIK/NF-kappaB signaling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
