ID:BICD2_HUMAN DESCRIPTION: RecName: Full=Protein bicaudal D homolog 2; Short=Bic-D 2; FUNCTION: May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by associating with these complexes. Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex (By similarity). SUBUNIT: Interacts with DCTN2 and RAB6A (By similarity). Interacts with NEK9. SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasm, cytoskeleton. Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Its localization is dependent on microtubule morphology. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The fourth coiled coil region is involved in Golgi targeting and in the interaction with DCTN2 (By similarity). PTM: Phosphorylated by NEK9 in vitro. SIMILARITY: Belongs to the BicD family. SEQUENCE CAUTION: Sequence=BAA31674.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09730 - Microtubule-associated protein Bicaudal-D
ModBase Predicted Comparative 3D Structure on Q8TD16
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0015031 protein transport GO:0034067 protein localization to Golgi apparatus GO:0051028 mRNA transport GO:0051642 centrosome localization GO:0070507 regulation of microtubule cytoskeleton organization GO:0072385 minus-end-directed organelle transport along microtubule GO:0072393 microtubule anchoring at microtubule organizing center
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
