Human Gene BIRC5 (ENST00000350051.8_4) from GENCODE V47lift37
  Description: baculoviral IAP repeat containing 5, transcript variant 1 (from RefSeq NM_001168.3)
Gencode Transcript: ENST00000350051.8_4
Gencode Gene: ENSG00000089685.15_12
Transcript (Including UTRs)
   Position: hg19 chr17:76,210,334-76,221,716 Size: 11,383 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr17:76,210,398-76,219,635 Size: 9,238 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:76,210,334-76,221,716)mRNA (may differ from genome)Protein (142 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: BIRC5
Diseases sorted by gene-association score: cervical carcinosarcoma (18), childhood malignant schwannoma (17), malignant pleural mesothelioma (15), vulvar intraepithelial neoplasia (13), ovarian epithelial cancer (13), adenocarcinoma (13), bladder transitional cell papilloma (10), cervical intraepithelial neoplasia (10), malignant peritoneal mesothelioma (9), benign meningioma (7), cervical cancer, somatic (7), hepatoblastoma (7), renal clear cell carcinoma (6), ovarian serous cystadenocarcinoma (6), severe congenital neutropenia (6), keratocystic odontogenic tumor (6), colorectal cancer (6), hepatocellular carcinoma (5), skin squamous cell carcinoma (5), lung cancer (5), chronic leukemia (5), serous cystadenocarcinoma (5), salivary gland cancer (5), cystadenocarcinoma (5), renal cell carcinoma (4), pancreatic cancer (3), adamantinoma of long bones (2), prostate cancer (2), breast cancer (2), ovarian cancer, somatic (2), chronic lymphocytic leukemia (2), gastric cancer, somatic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.99 RPKM in Testis
Total median expression: 10.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.2064-0.394 Picture PostScript Text
3' UTR -732.602081-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  AK301793 - Homo sapiens cDNA FLJ52793 complete cds.
AK223428 - Homo sapiens mRNA for baculoviral IAP repeat-containing protein 5 variant, clone: FCC110F06.
BC000784 - Homo sapiens baculoviral IAP repeat-containing 5, mRNA (cDNA clone IMAGE:3506845).
BC034148 - Homo sapiens baculoviral IAP repeat-containing 5, mRNA (cDNA clone MGC:32768 IMAGE:4656567), complete cds.
AY927772 - Homo sapiens survivin splice variant 2 alpha mRNA, complete cds, alternatively spliced.
BC008718 - Homo sapiens baculoviral IAP repeat-containing 5, mRNA (cDNA clone MGC:8592 IMAGE:2961114), complete cds.
JD408051 - Sequence 389075 from Patent EP1572962.
HM625836 - Homo sapiens baculoviral IAP repeat-containing 5 (BIRC5) mRNA, complete cds.
JD215127 - Sequence 196151 from Patent EP1572962.
AB028869 - Homo sapiens mRNA for survivin-beta, complete cds.
JD026371 - Sequence 7395 from Patent EP1572962.
AK311917 - Homo sapiens cDNA, FLJ92184, Homo sapiens baculoviral IAP repeat-containing 5 (survivin)(BIRC5), mRNA.
AF077350 - Homo sapiens inhibitor of apoptosis homolog mRNA, complete cds.
DD356880 - Method of Screening for Compound Regulating Translation of Specific mRNA.
BC065497 - Homo sapiens baculoviral IAP repeat-containing 5, mRNA (cDNA clone MGC:75168 IMAGE:5394399), complete cds.
KJ896442 - Synthetic construct Homo sapiens clone ccsbBroadEn_05836 BIRC5 gene, encodes complete protein.
AB590059 - Synthetic construct DNA, clone: pFN21AB8312, Homo sapiens BIRC5 gene for baculoviral IAP repeat-containing 5, without stop codon, in Flexi system.
AM393128 - Synthetic construct Homo sapiens clone IMAGE:100002035 for hypothetical protein (BIRC5 gene).
AY830084 - Homo sapiens survivin variant mRNA, complete cds, alternatively spliced.
DQ227257 - Homo sapiens survivin variant 3 alpha mRNA, complete cds.
DQ310375 - Homo sapiens cell-line HeLa survivin 3 alpha mRNA, complete cds.
DQ310376 - Homo sapiens cell-line Caco-2 survivin 3 alpha mRNA, complete cds.
DQ310377 - Homo sapiens cell-line MCF7 survivin 3 alpha mRNA, complete cds.
DQ310378 - Homo sapiens cell-line NB4 survivin 3 alpha mRNA, complete cds.
DQ310379 - Homo sapiens cell-line ZR-75 survivin 3 alpha mRNA, complete cds.
AB154416 - Homo sapiens mRNA for survivin-3B protein, complete cds.
CR541740 - Homo sapiens full open reading frame cDNA clone RZPDo834G0429D for gene BIRC5, baculoviral IAP repeat-containing 5 (survivin); complete cds, incl. stopcodon.
DQ508249 - Homo sapiens survivin isoform B+int2B/3B (BIRC5) mRNA, partial cds, alternatively spliced.
DQ508245 - Homo sapiens survivin isoform Ex2+4/2B/3B (BIRC5) mRNA, partial cds, alternatively spliced.
DQ508246 - Homo sapiens survivin isoform 2B/3B (BIRC5) mRNA, partial cds, alternatively spliced.
DQ508247 - Homo sapiens survivin isoform deltaEx3/3B (BIRC5) mRNA, partial cds, alternatively spliced.
DQ508248 - Homo sapiens survivin isoform 2B+32/3B (BIRC5) mRNA, partial cds, alternatively spliced.
JD021355 - Sequence 2379 from Patent EP1572962.
JD033697 - Sequence 14721 from Patent EP1572962.
JD027202 - Sequence 8226 from Patent EP1572962.
JD022361 - Sequence 3385 from Patent EP1572962.
JD021025 - Sequence 2049 from Patent EP1572962.
JD033635 - Sequence 14659 from Patent EP1572962.
DQ599223 - Homo sapiens piRNA piR-37289, complete sequence.
JD526791 - Sequence 507815 from Patent EP1572962.
JD553994 - Sequence 535018 from Patent EP1572962.
JD246033 - Sequence 227057 from Patent EP1572962.
JD537474 - Sequence 518498 from Patent EP1572962.
JD440691 - Sequence 421715 from Patent EP1572962.
JD445012 - Sequence 426036 from Patent EP1572962.
MA264848 - JP 2017508467-A/168: PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER.
MS942524 - Sequence 168 from Patent EP3116513.
JD489568 - Sequence 470592 from Patent EP1572962.
JD313867 - Sequence 294891 from Patent EP1572962.
MA264850 - JP 2017508467-A/170: PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER.
MS942526 - Sequence 170 from Patent EP3116513.
JD543490 - Sequence 524514 from Patent EP1572962.
MA264852 - JP 2017508467-A/172: PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER.
MS942528 - Sequence 172 from Patent EP3116513.
JD113916 - Sequence 94940 from Patent EP1572962.
JD336983 - Sequence 318007 from Patent EP1572962.
JD229179 - Sequence 210203 from Patent EP1572962.
MA264854 - JP 2017508467-A/174: PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER.
MS942530 - Sequence 174 from Patent EP3116513.
JD253443 - Sequence 234467 from Patent EP1572962.
JD184436 - Sequence 165460 from Patent EP1572962.
MA264856 - JP 2017508467-A/176: PHARMACEUTICAL COMPOSITIONS COMPRISING RNA AND USE FOR TREATING CANCER.
MS942532 - Sequence 176 from Patent EP3116513.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_bcellsurvivalPathway - B Cell Survival Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0B4J1S3, A0A0B4J1S3_HUMAN, BIRC5 , ENST00000350051.1, ENST00000350051.2, ENST00000350051.3, ENST00000350051.4, ENST00000350051.5, ENST00000350051.6, ENST00000350051.7, NM_001168, uc317xya.1, uc317xya.2
UCSC ID: ENST00000350051.8_4
RefSeq Accession: NM_001168.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.