ID:BMP5_HUMAN DESCRIPTION: RecName: Full=Bone morphogenetic protein 5; Short=BMP-5; Flags: Precursor; FUNCTION: Induces cartilage and bone formation. SUBUNIT: Homodimer; disulfide-linked (By similarity). SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in the lung and liver. SIMILARITY: Belongs to the TGF-beta family. WEB RESOURCE: Name=Wikipedia; Note=Bone morphogenetic protein 5 entry; URL="http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_5";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22003
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001501 skeletal system development GO:0001503 ossification GO:0003272 endocardial cushion formation GO:0003323 type B pancreatic cell development GO:0003344 pericardium morphogenesis GO:0007275 multicellular organism development GO:0007389 pattern specification process GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0010719 negative regulation of epithelial to mesenchymal transition GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010894 negative regulation of steroid biosynthetic process GO:0021502 neural fold elevation formation GO:0030154 cell differentiation GO:0030509 BMP signaling pathway GO:0030539 male genitalia development GO:0030902 hindbrain development GO:0032348 negative regulation of aldosterone biosynthetic process GO:0042981 regulation of apoptotic process GO:0043408 regulation of MAPK cascade GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043583 ear development GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048738 cardiac muscle tissue development GO:0050679 positive regulation of epithelial cell proliferation GO:0051216 cartilage development GO:0060037 pharyngeal system development GO:0060395 SMAD protein signal transduction GO:0060411 cardiac septum morphogenesis GO:0060710 chorio-allantoic fusion GO:0061384 heart trabecula morphogenesis GO:0071676 negative regulation of mononuclear cell migration GO:0097065 anterior head development GO:1900006 positive regulation of dendrite development GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1905069 allantois development GO:2000065 negative regulation of cortisol biosynthetic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
