The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22004
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001501 skeletal system development GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001654 eye development GO:0001822 kidney development GO:0001938 positive regulation of endothelial cell proliferation GO:0001958 endochondral ossification GO:0003323 type B pancreatic cell development GO:0006879 cellular iron ion homeostasis GO:0006954 inflammatory response GO:0006955 immune response GO:0007275 multicellular organism development GO:0008284 positive regulation of cell proliferation GO:0010039 response to iron ion GO:0010469 regulation of receptor activity GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0014823 response to activity GO:0030154 cell differentiation GO:0030501 positive regulation of bone mineralization GO:0030509 BMP signaling pathway GO:0030539 male genitalia development GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0032026 response to magnesium ion GO:0032332 positive regulation of chondrocyte differentiation GO:0032349 positive regulation of aldosterone biosynthetic process GO:0032526 response to retinoic acid GO:0042981 regulation of apoptotic process GO:0043408 regulation of MAPK cascade GO:0045603 positive regulation of endothelial cell differentiation GO:0045666 positive regulation of neuron differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050679 positive regulation of epithelial cell proliferation GO:0050714 positive regulation of protein secretion GO:0051216 cartilage development GO:0051384 response to glucocorticoid GO:0060391 positive regulation of SMAD protein import into nucleus GO:0060395 SMAD protein signal transduction GO:0060586 multicellular organismal iron ion homeostasis GO:0071260 cellular response to mechanical stimulus GO:0071281 cellular response to iron ion GO:0071773 cellular response to BMP stimulus GO:2000860 positive regulation of aldosterone secretion
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
