ID:DBC1_HUMAN DESCRIPTION: RecName: Full=Deleted in bladder cancer protein 1; AltName: Full=Protein FAM5A; Flags: Precursor; FUNCTION: Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway. INTERACTION: Q5BKZ1:ZNF326; NbExp=5; IntAct=EBI-3904864, EBI-2560158; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine. MISCELLANEOUS: DBC1 is silenced by methylation in 50% of bladder cancer cell lines. SIMILARITY: Belongs to the FAM5 family. SIMILARITY: Contains 1 MACPF domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60477
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
