ID:FBW1A_HUMAN DESCRIPTION: RecName: Full=F-box/WD repeat-containing protein 1A; AltName: Full=E3RSIkappaB; AltName: Full=Epididymis tissue protein Li 2a; AltName: Full=F-box and WD repeats protein beta-TrCP; AltName: Full=pIkappaBalpha-E3 receptor subunit; FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys- 21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Homodimer. Self-associates. Component of the SCF(BTRC) complex formed of CUL1, SKP1, RBX1 and a BTRC dimer. Direct interaction with SKP1 occurs via the F-box domain. Interacts with phosphorylated ubiquitination substrates SMAD3 and SMAD4. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, NFKBIB, NFKBIE, NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5 and SNAI1; the interaction requires the phosphorylation of the 2 serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S. Binds UBQLN1. Interacts with CDC34 and UBE2R2. Interacts with FBXW11. Interacts with CUL4A and DDB1. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with phosphorylated NKBIA and RELA; RELA interacts directly with NFKBIA. Interacts with HIV-1 Vpu. Interacts with the phosphorylated form of GLI3. Interacts with CLU. INTERACTION: Q00987:MDM2; NbExp=9; IntAct=EBI-307461, EBI-389668; P63208:SKP1; NbExp=4; IntAct=EBI-307461, EBI-307486; P30291:WEE1; NbExp=2; IntAct=EBI-307461, EBI-914695; SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in epididymis (at protein level). DOMAIN: The N-terminal D domain mediates homodimerization. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 7 WD repeats. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/BTRCID451ch10q24.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y297
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0005515 protein binding GO:0008013 beta-catenin binding GO:0016874 ligase activity GO:0045309 protein phosphorylated amino acid binding GO:0046983 protein dimerization activity GO:0061630 ubiquitin protein ligase activity
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0000209 protein polyubiquitination GO:0006470 protein dephosphorylation GO:0006511 ubiquitin-dependent protein catabolic process GO:0007165 signal transduction GO:0016032 viral process GO:0016055 Wnt signaling pathway GO:0016567 protein ubiquitination GO:0030163 protein catabolic process GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031648 protein destabilization GO:0033598 mammary gland epithelial cell proliferation GO:0038061 NIK/NF-kappaB signaling GO:0042752 regulation of circadian rhythm GO:0042753 positive regulation of circadian rhythm GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043687 post-translational protein modification GO:0045862 positive regulation of proteolysis GO:0045879 negative regulation of smoothened signaling pathway GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0048511 rhythmic process GO:0051403 stress-activated MAPK cascade GO:0051726 regulation of cell cycle GO:0060444 branching involved in mammary gland duct morphogenesis GO:0060828 regulation of canonical Wnt signaling pathway GO:0061136 regulation of proteasomal protein catabolic process GO:0070498 interleukin-1-mediated signaling pathway GO:0071407 cellular response to organic cyclic compound
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
