Human Gene BZW2 (ENST00000258761.8_5) from GENCODE V47lift37
  Description: basic leucine zipper and W2 domains 2, transcript variant 2 (from RefSeq NM_014038.3)
Gencode Transcript: ENST00000258761.8_5
Gencode Gene: ENSG00000136261.16_9
Transcript (Including UTRs)
   Position: hg19 chr7:16,685,806-16,746,142 Size: 60,337 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr7:16,705,069-16,745,713 Size: 40,645 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:16,685,806-16,746,142)mRNA (may differ from genome)Protein (419 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BZW2_HUMAN
DESCRIPTION: RecName: Full=Basic leucine zipper and W2 domain-containing protein 2;
FUNCTION: May be involved in neuronal differentiation (By similarity).
SIMILARITY: Belongs to the BZW family.
SIMILARITY: Contains 1 W2 domain.
SEQUENCE CAUTION: Sequence=AAI07758.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 96.85 RPKM in Heart - Left Ventricle
Total median expression: 938.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.90115-0.269 Picture PostScript Text
3' UTR -103.60429-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR016021 - MIF4-like_typ_1/2/3
IPR003307 - W2_domain

Pfam Domains:
PF02020 - eIF4-gamma/eIF5/eIF2-epsilon

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q9Y6E2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0045296 cadherin binding

Biological Process:
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0030154 cell differentiation

Cellular Component:
GO:0005737 cytoplasm
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AF083246 - Homo sapiens HSPC028 mRNA, complete cds.
BC009597 - Homo sapiens basic leucine zipper and W2 domains 2, mRNA (cDNA clone MGC:14688 IMAGE:4134371), complete cds.
AK001218 - Homo sapiens cDNA FLJ10356 fis, clone NT2RM2001201, weakly similar to EUKARYOTIC TRANSLATION INITIATION FACTOR 5.
AK001260 - Homo sapiens cDNA FLJ10398 fis, clone NT2RM4000349, highly similar to Homo sapiens basic leucine zipper and W2 domains 2 (BZW2), mRNA.
AK297496 - Homo sapiens cDNA FLJ52869 complete cds, highly similar to Homo sapiens basic leucine zipper and W2 domains 2 (BZW2), mRNA.
BC107757 - Homo sapiens basic leucine zipper and W2 domains 2, mRNA (cDNA clone IMAGE:6737724), partial cds.
BC008453 - Homo sapiens basic leucine zipper and W2 domains 2, mRNA (cDNA clone MGC:14699 IMAGE:4246219), complete cds.
AK300655 - Homo sapiens cDNA FLJ59990 complete cds, highly similar to Rattus norvegicus basic leucine zipper and W2 domains 2 (Bzw2), mRNA.
BC051898 - Homo sapiens basic leucine zipper and W2 domains 2, mRNA (cDNA clone IMAGE:3922798), containing frame-shift errors.
BC003056 - Homo sapiens basic leucine zipper and W2 domains 2, mRNA (cDNA clone MGC:976 IMAGE:3544869), complete cds.
JD155731 - Sequence 136755 from Patent EP1572962.
AK027837 - Homo sapiens cDNA FLJ14931 fis, clone PLACE1009434.
BC017794 - Homo sapiens basic leucine zipper and W2 domains 2, mRNA (cDNA clone IMAGE:4245135), complete cds.
CU678348 - Synthetic construct Homo sapiens gateway clone IMAGE:100017227 5' read BZW2 mRNA.
DQ895708 - Synthetic construct Homo sapiens clone IMAGE:100010168; FLH186853.01L; RZPDo839B0362D basic leucine zipper and W2 domains 2 (BZW2) gene, encodes complete protein.
KJ906129 - Synthetic construct Homo sapiens clone ccsbBroadEn_15799 BZW2 gene, encodes complete protein.
DQ892496 - Synthetic construct clone IMAGE:100005126; FLH186857.01X; RZPDo839B0372D basic leucine zipper and W2 domains 2 (BZW2) gene, encodes complete protein.
KJ893653 - Synthetic construct Homo sapiens clone ccsbBroadEn_03047 BZW2 gene, encodes complete protein.
AF110323 - Homo sapiens MSTP017 (MST017) mRNA, complete cds.
JD024654 - Sequence 5678 from Patent EP1572962.
JD032586 - Sequence 13610 from Patent EP1572962.
BC001570 - Homo sapiens basic leucine zipper and W2 domains 2, mRNA (cDNA clone IMAGE:3452691).
JD020981 - Sequence 2005 from Patent EP1572962.
JD029279 - Sequence 10303 from Patent EP1572962.
JD024434 - Sequence 5458 from Patent EP1572962.
JD035901 - Sequence 16925 from Patent EP1572962.
JD202653 - Sequence 183677 from Patent EP1572962.
JD309468 - Sequence 290492 from Patent EP1572962.
JD362962 - Sequence 343986 from Patent EP1572962.
JD062228 - Sequence 43252 from Patent EP1572962.
JD304575 - Sequence 285599 from Patent EP1572962.
JD394333 - Sequence 375357 from Patent EP1572962.
JD371179 - Sequence 352203 from Patent EP1572962.
JD147211 - Sequence 128235 from Patent EP1572962.
JD236593 - Sequence 217617 from Patent EP1572962.
JD327735 - Sequence 308759 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: 5MP1 , 5MP1_HUMAN, A4D123, ENST00000258761.1, ENST00000258761.2, ENST00000258761.3, ENST00000258761.4, ENST00000258761.5, ENST00000258761.6, ENST00000258761.7, HSPC028, MSTP017, NM_014038, Q3B779, Q96JW5, Q9H3F7, Q9Y6E2, uc317gdy.1, uc317gdy.2
UCSC ID: ENST00000258761.8_5
RefSeq Accession: NM_014038.3
Protein: Q9Y6E2 (aka BZW2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.