Human Gene C2CD5 (ENST00000446597.6_11) from GENCODE V47lift37
  Description: C2 calcium dependent domain containing 5, transcript variant 18 (from RefSeq NM_001385333.1)
Gencode Transcript: ENST00000446597.6_11
Gencode Gene: ENSG00000111731.13_16
Transcript (Including UTRs)
   Position: hg19 chr12:22,601,517-22,697,476 Size: 95,960 Total Exon Count: 27 Strand: -
Coding Region
   Position: hg19 chr12:22,602,694-22,697,084 Size: 94,391 Coding Exon Count: 26 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:22,601,517-22,697,476)mRNA (may differ from genome)Protein (1051 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K0528_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein KIAA0528;
SIMILARITY: Contains 1 C2 domain.
SEQUENCE CAUTION: Sequence=BAA25454.3; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.45 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 551.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -101.40252-0.402 Picture PostScript Text
3' UTR -256.101177-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR018029 - C2_membr_targeting

Pfam Domains:
PF00168 - C2 domain

SCOP Domains:
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
117782 - YbjQ-like

ModBase Predicted Comparative 3D Structure on Q86YS7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008289 lipid binding

Biological Process:
GO:0006906 vesicle fusion
GO:0010828 positive regulation of glucose transport
GO:0015031 protein transport
GO:0031340 positive regulation of vesicle fusion
GO:0032869 cellular response to insulin stimulus
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0065002 intracellular protein transmembrane transport
GO:0072659 protein localization to plasma membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:2001275 positive regulation of glucose import in response to insulin stimulus

Cellular Component:
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0032587 ruffle membrane
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  LF207461 - JP 2014500723-A/14964: Polycomb-Associated Non-Coding RNAs.
BC053885 - Homo sapiens KIAA0528, mRNA (cDNA clone IMAGE:6058279), partial cds.
BC042498 - Homo sapiens KIAA0528, mRNA (cDNA clone MGC:35269 IMAGE:5174801), complete cds.
AY166851 - Homo sapiens hypothetical protein mRNA, complete cds.
AB011100 - Homo sapiens KIAA0528 mRNA for KIAA0528 protein.
BC117143 - Homo sapiens KIAA0528, mRNA (cDNA clone MGC:150752 IMAGE:40125694), complete cds.
BC143859 - Homo sapiens KIAA0528, mRNA (cDNA clone MGC:177392 IMAGE:9052375), complete cds.
BC143860 - Homo sapiens KIAA0528, mRNA (cDNA clone MGC:177393 IMAGE:9052376), complete cds.
BC143878 - Homo sapiens KIAA0528, mRNA (cDNA clone MGC:177411 IMAGE:9052394), complete cds.
AK299353 - Homo sapiens cDNA FLJ54447 complete cds.
AK295862 - Homo sapiens cDNA FLJ60272 complete cds.
AB385344 - Synthetic construct DNA, clone: pF1KA0528, Homo sapiens KIAA0528 gene for KIAA0528 protein, complete cds, without stop codon, in Flexi system.
AK310753 - Homo sapiens cDNA, FLJ17795.
MA443038 - JP 2018138019-A/14964: Polycomb-Associated Non-Coding RNAs.
BX648560 - Homo sapiens mRNA; cDNA DKFZp779N2044 (from clone DKFZp779N2044).
LF366388 - JP 2014500723-A/173891: Polycomb-Associated Non-Coding RNAs.
JD037457 - Sequence 18481 from Patent EP1572962.
JD316102 - Sequence 297126 from Patent EP1572962.
LF366389 - JP 2014500723-A/173892: Polycomb-Associated Non-Coding RNAs.
JD534908 - Sequence 515932 from Patent EP1572962.
LF366390 - JP 2014500723-A/173893: Polycomb-Associated Non-Coding RNAs.
LF366391 - JP 2014500723-A/173894: Polycomb-Associated Non-Coding RNAs.
JD434071 - Sequence 415095 from Patent EP1572962.
LF366392 - JP 2014500723-A/173895: Polycomb-Associated Non-Coding RNAs.
JD564846 - Sequence 545870 from Patent EP1572962.
JD066904 - Sequence 47928 from Patent EP1572962.
LF366393 - JP 2014500723-A/173896: Polycomb-Associated Non-Coding RNAs.
LF366395 - JP 2014500723-A/173898: Polycomb-Associated Non-Coding RNAs.
LF366396 - JP 2014500723-A/173899: Polycomb-Associated Non-Coding RNAs.
LF366408 - JP 2014500723-A/173911: Polycomb-Associated Non-Coding RNAs.
LF366411 - JP 2014500723-A/173914: Polycomb-Associated Non-Coding RNAs.
LF366412 - JP 2014500723-A/173915: Polycomb-Associated Non-Coding RNAs.
LF366414 - JP 2014500723-A/173917: Polycomb-Associated Non-Coding RNAs.
LF366419 - JP 2014500723-A/173922: Polycomb-Associated Non-Coding RNAs.
LF366428 - JP 2014500723-A/173931: Polycomb-Associated Non-Coding RNAs.
MA601965 - JP 2018138019-A/173891: Polycomb-Associated Non-Coding RNAs.
MA601966 - JP 2018138019-A/173892: Polycomb-Associated Non-Coding RNAs.
MA601967 - JP 2018138019-A/173893: Polycomb-Associated Non-Coding RNAs.
MA601968 - JP 2018138019-A/173894: Polycomb-Associated Non-Coding RNAs.
MA601969 - JP 2018138019-A/173895: Polycomb-Associated Non-Coding RNAs.
MA601970 - JP 2018138019-A/173896: Polycomb-Associated Non-Coding RNAs.
MA601972 - JP 2018138019-A/173898: Polycomb-Associated Non-Coding RNAs.
MA601973 - JP 2018138019-A/173899: Polycomb-Associated Non-Coding RNAs.
MA601985 - JP 2018138019-A/173911: Polycomb-Associated Non-Coding RNAs.
MA601988 - JP 2018138019-A/173914: Polycomb-Associated Non-Coding RNAs.
MA601989 - JP 2018138019-A/173915: Polycomb-Associated Non-Coding RNAs.
MA601991 - JP 2018138019-A/173917: Polycomb-Associated Non-Coding RNAs.
MA601996 - JP 2018138019-A/173922: Polycomb-Associated Non-Coding RNAs.
MA602005 - JP 2018138019-A/173931: Polycomb-Associated Non-Coding RNAs.
LF366443 - JP 2014500723-A/173946: Polycomb-Associated Non-Coding RNAs.
JD099030 - Sequence 80054 from Patent EP1572962.
JD309745 - Sequence 290769 from Patent EP1572962.
JD172662 - Sequence 153686 from Patent EP1572962.
JD266319 - Sequence 247343 from Patent EP1572962.
MA602020 - JP 2018138019-A/173946: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86YS7 (Reactome details) participates in the following event(s):

R-HSA-5260201 p-AKT2 phosphorylates C2CD5
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: B4DJ03, B4DRN7, B7ZLL0, C2CD5_HUMAN, CDP138, ENST00000446597.1, ENST00000446597.2, ENST00000446597.3, ENST00000446597.4, ENST00000446597.5, F5H2A1, F5H5R1, KIAA0528, NM_001385333, O60280, Q17RY7, Q7Z619, Q86SU3, Q86YS7, uc320ogr.1, uc320ogr.2
UCSC ID: ENST00000446597.6_11
RefSeq Accession: NM_001286176.2
Protein: Q86YS7 (aka K0528_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.